ID A0A0N5CW26_THECL Unreviewed; 1204 AA.
AC A0A0N5CW26;
DT 09-DEC-2015, integrated into UniProtKB/TrEMBL.
DT 08-JUN-2016, sequence version 2.
DT 27-MAR-2024, entry version 38.
DE SubName: Full=SAP domain-containing protein {ECO:0000313|WBParaSite:TCLT_0000453601-mRNA-1};
GN ORFNames=TCLT_LOCUS4525 {ECO:0000313|EMBL:VDN01647.1};
OS Thelazia callipaeda (Oriental eyeworm) (Parasitic nematode).
OC Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC Spirurina; Spiruromorpha; Thelazioidea; Thelaziidae; Thelazia.
OX NCBI_TaxID=103827 {ECO:0000313|Proteomes:UP000046394, ECO:0000313|WBParaSite:TCLT_0000453601-mRNA-1};
RN [1] {ECO:0000313|WBParaSite:TCLT_0000453601-mRNA-1}
RP IDENTIFICATION.
RG WormBaseParasite;
RL Submitted (APR-2016) to UniProtKB.
RN [2] {ECO:0000313|EMBL:VDN01647.1, ECO:0000313|Proteomes:UP000276776}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RG Pathogen Informatics;
RL Submitted (NOV-2018) to the EMBL/GenBank/DDBJ databases.
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DR EMBL; UYYF01004291; VDN01647.1; -; Genomic_DNA.
DR STRING; 103827.A0A0N5CW26; -.
DR WBParaSite; TCLT_0000453601-mRNA-1; TCLT_0000453601-mRNA-1; TCLT_0000453601.
DR OMA; LRYSDMH; -.
DR Proteomes; UP000046394; Unplaced.
DR Proteomes; UP000276776; Unassembled WGS sequence.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-KW.
DR GO; GO:0005509; F:calcium ion binding; IEA:InterPro.
DR GO; GO:0007049; P:cell cycle; IEA:UniProtKB-KW.
DR GO; GO:0006355; P:regulation of DNA-templated transcription; IEA:InterPro.
DR Gene3D; 1.10.238.10; EF-hand; 1.
DR Gene3D; 1.10.720.30; SAP domain; 1.
DR InterPro; IPR045354; BURAN.
DR InterPro; IPR025224; CCAR1/CCAR2.
DR InterPro; IPR025954; DBC1/CARP1_inactive_NUDIX_dom.
DR InterPro; IPR011992; EF-hand-dom_pair.
DR InterPro; IPR002048; EF_hand_dom.
DR InterPro; IPR045353; LAIKA.
DR InterPro; IPR025223; S1-like_RNA-bd_dom.
DR InterPro; IPR003034; SAP_dom.
DR InterPro; IPR036361; SAP_dom_sf.
DR PANTHER; PTHR14304; CELL DIVISION CYCLE AND APOPTOSIS REGULATOR PROTEIN; 1.
DR PANTHER; PTHR14304:SF11; SAP DOMAIN-CONTAINING PROTEIN; 1.
DR Pfam; PF19257; BURAN; 1.
DR Pfam; PF14443; DBC1; 1.
DR Pfam; PF19256; LAIKA; 1.
DR Pfam; PF14444; S1-like; 1.
DR Pfam; PF02037; SAP; 1.
DR SMART; SM01122; DBC1; 1.
DR SMART; SM00513; SAP; 1.
DR SUPFAM; SSF47473; EF-hand; 1.
DR SUPFAM; SSF68906; SAP domain; 1.
DR PROSITE; PS50222; EF_HAND_2; 1.
DR PROSITE; PS50800; SAP; 1.
PE 4: Predicted;
KW Activator {ECO:0000256|ARBA:ARBA00023159};
KW Cell cycle {ECO:0000256|ARBA:ARBA00023306};
KW Coiled coil {ECO:0000256|ARBA:ARBA00023054, ECO:0000256|SAM:Coils};
KW Cytoplasm {ECO:0000256|ARBA:ARBA00022490};
KW Phosphoprotein {ECO:0000256|ARBA:ARBA00022553};
KW Reference proteome {ECO:0000313|Proteomes:UP000276776}.
FT DOMAIN 643..677
FT /note="SAP"
FT /evidence="ECO:0000259|PROSITE:PS50800"
FT DOMAIN 868..903
FT /note="EF-hand"
FT /evidence="ECO:0000259|PROSITE:PS50222"
FT REGION 151..177
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 192..324
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 596..638
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 680..711
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 831..858
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 944..967
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1091..1161
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1182..1204
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 997..1060
FT /evidence="ECO:0000256|SAM:Coils"
FT COMPBIAS 216..234
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 282..298
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 299..319
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 596..619
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 832..858
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1093..1148
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1186..1204
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1204 AA; 135455 MW; 763BE8DE00861684 CRC64;
MSQFGPKNPA AWTRPPGANQ QLNAGLFQNP LIGAQPFAQM GMINAAAFSQ QAVGSMGMNL
SMLQAPSQTL RMQAQQQSFQ QKNRTFSGVV TKMHDNYGFI DDDVFFQVRG SLPRAGDRVM
VEASYNPTMP FKWNAYRVQL IGDKGGPGPV SIVGVNSNSG NGLSAHTPPD RGRQAVPGRG
LMSVEQSWAV KSVEKQQSVS HVNDSRTRDF RPSPRTRSPV GSNRHRSPRN VPSGPSAVAQ
DARRLSPPRR ISPRGIARRS PRRSPLRDYA KGAVSRSSPK HLTPVRKHEG KREHSASASG
RNRSPSQKQD PNTHSSLSPP RRRARVIPRY QCYLPKAPIS NEVEQTVMQL RKRYPSLYIP
SDFSDASIEW PKRTPIENPL SISATPITFH ILHKDVDYPG EKLPVLNPPD LDNRFSAKVV
LMSHQGLSIL HQKAFGLQVD GSIDENSDSA SLKRCINFVV GVRNKEMMAI GGAWSPSLDG
DNPDSDPRVL IRTSIRTVRA LCGVDLSKCS KWYKMAEIRY YRAEKDRMDT CCLFLPDTSG
LMPTNDCYQQ LLATLKNQLR RKLAAVDAQK VVLPSTVAVS ATDSGEAGEG NAITTESTAL
SGDSQRQKQQ SQQQTDTNKE QGQELEEDDD EDLNPTHWSK LDIKTMKVAE LRQELMARDL
ETKGIKSVLY ARLQEAIDRE KAEEEGRENK DDESVLKQEE KREEKELTDE DKKAVERFEK
EKKEKKCSIE RHFVVPKEPG ILVYPSRLAK GGKFDCKIVS LHAMLDYRIE DNKEHSFELA
VMAECISEML DRSQAFTVYK ALSCALDKDS EKKRRDEAKL AEVFGSKEII QSGKTDKPEK
SEEEKKKEDE KREEEQKKVL TEARKPIVID RAVFQAFAHF DQNLCGYVLE KDLEEILHSM
GLNISRAQLQ KLLKKHVSRD RVSYRFLTDS WANKDGTVTY RPGIVSNPPS TEQLSKGNVS
KESNISTKTN DVSDVNCAES VMYLGALVNI PQVMDQVARM EADRNVALQK VDVLEAQLSN
FYNIGGEDSA KHIQTLEKRK KRLDEDVEKY RKRLHDAEKC LKNSVDDTVQ MKSTIQEFRR
IGERMVTMAE KLMPNPKEEE KASERDEKDV KREKKDEKED KKVVKKKEPA ASKLNGEAEE
KKELQLVDEV GSNDVGDEPM ETDVIVLSEE LIGDDEKEIK KEVVPSQDSP VSQEINPCLT
SVTE
//
