ID   A0A0N5CWR4_THECL        Unreviewed;       787 AA.
AC   A0A0N5CWR4;
DT   09-DEC-2015, integrated into UniProtKB/TrEMBL.
DT   09-DEC-2015, sequence version 1.
DT   27-MAR-2024, entry version 27.
DE   SubName: Full=Solute carrier family 12 member 6 {ECO:0000313|WBParaSite:TCLT_0000479401-mRNA-1};
GN   ORFNames=TCLT_LOCUS4783 {ECO:0000313|EMBL:VDN01947.1};
OS   Thelazia callipaeda (Oriental eyeworm) (Parasitic nematode).
OC   Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC   Spirurina; Spiruromorpha; Thelazioidea; Thelaziidae; Thelazia.
OX   NCBI_TaxID=103827 {ECO:0000313|Proteomes:UP000046394, ECO:0000313|WBParaSite:TCLT_0000479401-mRNA-1};
RN   [1] {ECO:0000313|WBParaSite:TCLT_0000479401-mRNA-1}
RP   IDENTIFICATION.
RG   WormBaseParasite;
RL   Submitted (FEB-2017) to UniProtKB.
RN   [2] {ECO:0000313|EMBL:VDN01947.1, ECO:0000313|Proteomes:UP000276776}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RG   Pathogen Informatics;
RL   Submitted (NOV-2018) to the EMBL/GenBank/DDBJ databases.
CC   -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC       pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
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DR   EMBL; UYYF01004304; VDN01947.1; -; Genomic_DNA.
DR   STRING; 103827.A0A0N5CWR4; -.
DR   WBParaSite; TCLT_0000479401-mRNA-1; TCLT_0000479401-mRNA-1; TCLT_0000479401.
DR   OMA; IWWIVQD; -.
DR   Proteomes; UP000046394; Unplaced.
DR   Proteomes; UP000276776; Unassembled WGS sequence.
DR   GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0015377; F:chloride:monoatomic cation symporter activity; IEA:InterPro.
DR   Gene3D; 1.20.1740.10; Amino acid/polyamine transporter I; 1.
DR   InterPro; IPR004841; AA-permease/SLC12A_dom.
DR   InterPro; IPR018491; SLC12_C.
DR   InterPro; IPR004842; SLC12A_fam.
DR   PANTHER; PTHR11827:SF55; POTASSIUM_CHLORIDE COTRANSPORTER 3; 1.
DR   PANTHER; PTHR11827; SOLUTE CARRIER FAMILY 12, CATION COTRANSPORTERS; 1.
DR   Pfam; PF00324; AA_permease; 1.
DR   Pfam; PF03522; SLC12; 1.
PE   4: Predicted;
KW   Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW   Reference proteome {ECO:0000313|Proteomes:UP000276776};
KW   Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW   ECO:0000256|SAM:Phobius}.
FT   TRANSMEM        12..31
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        36..59
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        65..88
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        95..115
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        135..155
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        248..266
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        278..301
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        322..348
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        383..402
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        409..429
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   DOMAIN          4..415
FT                   /note="Amino acid permease/ SLC12A"
FT                   /evidence="ECO:0000259|Pfam:PF00324"
FT   DOMAIN          636..703
FT                   /note="SLC12A transporter C-terminal"
FT                   /evidence="ECO:0000259|Pfam:PF03522"
SQ   SEQUENCE   787 AA;  87290 MW;  736325402336CF6D CRC64;
     MLGVYLPTIQ HILGVTMFIR LAWVVGIAGI IDTMILLFLC CLCTLLTSIS LSAVATNGIV
     EGGGVYFMIS RNLGAEFGSA VGILFYLANT VAASMYLVGG VEVMLLYIFP SLTIGGNEVH
     SDTGLWGMMS HNYRIYGSAF LLLEVMIVAM GVRFVQLLAP VRFSLHLFTS SVIESYSISD
     DFCNRTTASF CTHFTASMLK CTNAFPGINA ENFYNNLKRM YMEAGESYPG VAADDAGLEV
     SQDFRTSFFI LLAIYFPAVT GIMTGTNMSG DLKDPQRSIP YGTIAATLTT STIYYALALL
     FGASITGPVL RDKFGRSLDS SMIVALLSWP SPWVVIIGSF LSTFGAALQC LCSAPRLLQS
     IAKDDVIPLL APFAKVTKSN EPFLGLLITA FIAEFAILLG AVDKIAEVLD FFFLMSLSLT
     GAGLCFFIMF ASRWQYAILS IIQTFIIYKY VEWKGTKKEW GDGIRGLALS TAQYSLLKVE
     DKDPHPKNWR PQLLVLMYGA WSKDIIDMRY VNLINLAGQL KAGRGLAIVV ALIKGSVSNR
     FYFQVKERIQ RDMLQVHLRG FGKTINFACK FQIDGCITTL FQSIGIGGLK PNTVLINWPE
     RPEENEIFAV ELIEAVANDE CIMLTKGITA FPLSSNDRLT GCIDIWWISH DGGLLMLVAF
     LLKQHKVWRG CELRIFATPE IPEKSTDLKE MLQKYIYMLR IDAAVYVSLA WSHFQESIHL
     NTIKRFNDVI VENSYQSQLV LLNLPRPSTE KNTIISHYIN YVNALTHNLQ RILFIGGSGK
     EVVTAHS
//