ID A0A0N5CYP4_THECL Unreviewed; 294 AA.
AC A0A0N5CYP4;
DT 09-DEC-2015, integrated into UniProtKB/TrEMBL.
DT 09-DEC-2015, sequence version 1.
DT 27-MAR-2024, entry version 23.
DE RecName: Full=Major sperm protein {ECO:0000256|RuleBase:RU003425};
GN ORFNames=TCLT_LOCUS5565 {ECO:0000313|EMBL:VDN02825.1};
OS Thelazia callipaeda (Oriental eyeworm) (Parasitic nematode).
OC Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC Spirurina; Spiruromorpha; Thelazioidea; Thelaziidae; Thelazia.
OX NCBI_TaxID=103827 {ECO:0000313|Proteomes:UP000046394, ECO:0000313|WBParaSite:TCLT_0000557601-mRNA-1};
RN [1] {ECO:0000313|WBParaSite:TCLT_0000557601-mRNA-1}
RP IDENTIFICATION.
RG WormBaseParasite;
RL Submitted (FEB-2017) to UniProtKB.
RN [2] {ECO:0000313|EMBL:VDN02825.1, ECO:0000313|Proteomes:UP000276776}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RG Pathogen Informatics;
RL Submitted (NOV-2018) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: Central component in molecular interactions underlying sperm
CC crawling. Forms an extensive filament system that extends from sperm
CC villipoda, along the leading edge of the pseudopod.
CC {ECO:0000256|RuleBase:RU003425}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; UYYF01004347; VDN02825.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A0N5CYP4; -.
DR STRING; 103827.A0A0N5CYP4; -.
DR WBParaSite; TCLT_0000557601-mRNA-1; TCLT_0000557601-mRNA-1; TCLT_0000557601.
DR OMA; AWEEKKS; -.
DR Proteomes; UP000046394; Unplaced.
DR Proteomes; UP000276776; Unassembled WGS sequence.
DR GO; GO:0005856; C:cytoskeleton; IEA:UniProtKB-KW.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR Gene3D; 2.60.40.10; Immunoglobulins; 1.
DR InterPro; IPR013783; Ig-like_fold.
DR InterPro; IPR000535; MSP_dom.
DR InterPro; IPR008962; PapD-like_sf.
DR PANTHER; PTHR21515:SF4; CYLICIN HOMOLOGUE-RELATED; 1.
DR PANTHER; PTHR21515; MAJOR SPERM PROTEIN; 1.
DR Pfam; PF00635; Motile_Sperm; 1.
DR SUPFAM; SSF49354; PapD-like; 1.
DR PROSITE; PS50202; MSP; 1.
PE 4: Predicted;
KW Cytoplasm {ECO:0000256|RuleBase:RU003425};
KW Cytoskeleton {ECO:0000256|RuleBase:RU003425};
KW Membrane {ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000276776};
KW Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT TRANSMEM 6..24
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 267..285
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 195..294
FT /note="MSP"
FT /evidence="ECO:0000259|PROSITE:PS50202"
FT REGION 27..195
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 30..195
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 294 AA; 33935 MW; 3A02E0DBA3A7D669 CRC64;
MWSLLTAISV IEVFIIVAYV AVLCKAKKTG SQKEGAKTKD ESAATEKTAD VNLKSEKGRK
EDEHKKSEGE GKEGSRKENK ENEADAKENE EKKENEKKNE ENKEEEKKEE EKKKDHEKEG
EEKDNEEKHE TEKENQKKEE NEKEAEKKDE EKKESNKKKE NHKEPDEKDD QEEDKKEKKN
NEKHGDKKEE EEKGDITYSP KELIFTTSGG TVKLITKNNT DERQALKVKC SDNKLYRVNP
VFSFVEPGVE QVIEVIRQGG NPKTDKLVLV HTPVRLFILA CLYFAQKISC MFSN
//
