ID A0A0N5CYS5_THECL Unreviewed; 1021 AA.
AC A0A0N5CYS5;
DT 09-DEC-2015, integrated into UniProtKB/TrEMBL.
DT 09-DEC-2015, sequence version 1.
DT 27-MAR-2024, entry version 29.
DE SubName: Full=MIF4G domain-containing protein {ECO:0000313|WBParaSite:TCLT_0000561101-mRNA-1};
GN ORFNames=TCLT_LOCUS5600 {ECO:0000313|EMBL:VDN02864.1};
OS Thelazia callipaeda (Oriental eyeworm) (Parasitic nematode).
OC Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC Spirurina; Spiruromorpha; Thelazioidea; Thelaziidae; Thelazia.
OX NCBI_TaxID=103827 {ECO:0000313|Proteomes:UP000046394, ECO:0000313|WBParaSite:TCLT_0000561101-mRNA-1};
RN [1] {ECO:0000313|WBParaSite:TCLT_0000561101-mRNA-1}
RP IDENTIFICATION.
RG WormBaseParasite;
RL Submitted (FEB-2017) to UniProtKB.
RN [2] {ECO:0000313|EMBL:VDN02864.1, ECO:0000313|Proteomes:UP000276776}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RG Pathogen Informatics;
RL Submitted (NOV-2018) to the EMBL/GenBank/DDBJ databases.
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DR EMBL; UYYF01004349; VDN02864.1; -; Genomic_DNA.
DR STRING; 103827.A0A0N5CYS5; -.
DR WBParaSite; TCLT_0000561101-mRNA-1; TCLT_0000561101-mRNA-1; TCLT_0000561101.
DR OMA; IWPDEDT; -.
DR Proteomes; UP000046394; Unplaced.
DR Proteomes; UP000276776; Unassembled WGS sequence.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-KW.
DR GO; GO:0003723; F:RNA binding; IEA:InterPro.
DR GO; GO:0000184; P:nuclear-transcribed mRNA catabolic process, nonsense-mediated decay; IEA:InterPro.
DR Gene3D; 1.25.40.180; -; 3.
DR InterPro; IPR016024; ARM-type_fold.
DR InterPro; IPR003890; MIF4G-like_typ-3.
DR InterPro; IPR039762; Nmd2/UPF2.
DR PANTHER; PTHR12839; NONSENSE-MEDIATED MRNA DECAY PROTEIN 2 UP-FRAMESHIFT SUPPRESSOR 2; 1.
DR PANTHER; PTHR12839:SF7; REGULATOR OF NONSENSE TRANSCRIPTS 2; 1.
DR Pfam; PF02854; MIF4G; 3.
DR SMART; SM00543; MIF4G; 3.
DR SUPFAM; SSF48371; ARM repeat; 3.
PE 4: Predicted;
KW Cytoplasm {ECO:0000256|ARBA:ARBA00022490};
KW Reference proteome {ECO:0000313|Proteomes:UP000276776}.
FT DOMAIN 48..245
FT /note="MIF4G"
FT /evidence="ECO:0000259|SMART:SM00543"
FT DOMAIN 424..616
FT /note="MIF4G"
FT /evidence="ECO:0000259|SMART:SM00543"
FT DOMAIN 630..842
FT /note="MIF4G"
FT /evidence="ECO:0000259|SMART:SM00543"
FT REGION 376..401
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 868..900
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 376..399
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 885..900
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1021 AA; 117513 MW; 52C86E9C4EA442B0 CRC64;
MVDMDEERLQ IYIRDLERRT QSQVADRTKL KDAIPLSETQ LRKMDSTLKK TTAFLKKLKN
FGTAQFESLL QDIEKVNLSK FLEEMAKTVA DIKLKYSDVQ AIVNICVHLS CYYEEFSRNL
LLEFRKLLPV KRNDKIQNPS KLRVDIRLLG ELCLHGVFQK DGLQLLGSAL AFLTLTDKTD
HLNIPILLPF CKTMNADLLG LHPYSVKQFA LAANVELPET TVLPGEHQKP LAQLLLDYHD
LHEMNHLLLS VKRQIRNRGD ASSEDKNQLE EVRVRYEKIL TCGIQLSEFL GLEMEEMKEE
QSEDEEEEIS ALALSRALQE GTITIWPDED TRQFYETRME LRELVPAILF QESEKRTLDL
VEREIEDVDL SGLESISEEP EEEVDGHVEG VEEEEEVNTG SAETYASVAV KQAEGQKMTG
LDLKVMINAF MEELPWLINR DLIDQAALNF VTNLNTKNNR RKLCQMMLEQ HQNRLDLLPF
YGRLVATLEP VMPDLALELS HSLLRQFRAS VKNRTEYSLS RKLRCCRFIS ELVKFGTIPK
AEGLTCLRMV LFDFRGHNID MCCTMVDAMG QFLYRSTDSH GKMKTLLEVM MKKRERINDT
HKQMIIDNAF FTCIPPPLEE KPKAESDPVH DFICYLLSSL SRCRMEITLR CFRKLDWADP
ELANFAVGCL SNPSLPRYSS IPHLASLIAA LSSYHDWIGI RVLDATLEDI RIALEMNSFS
FNQSLVLSVM LLGQLYNYSV CDSPIIFKTL YQLITFGAFD PLLDNWNNLA RINLVCDLLL
VCGEYFNSGS AKSRLDCFLA YFYRYFVVKE EAFKVRNIAF PKNVRLYVRF RVEEMNDYVR
KDTKIPDSFD EAQKAIDIIQ QRYKNAMESS TRGESLQTVE DMEEEEEEPR KRQLITDAKD
EEIGSSENIN ALVYDDNEQV NVHTSHISQP EDELFVQTSA GDSKLENISN SKTETKMAIL
TRGKGNKTVL KAIAMDIPDS LTKIWNAQRE KERQELTVHK HITLSMNERM MMDADSDSLS
D
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