ID   A0A0N5CZL4_THECL        Unreviewed;      1064 AA.
AC   A0A0N5CZL4;
DT   09-DEC-2015, integrated into UniProtKB/TrEMBL.
DT   09-DEC-2015, sequence version 1.
DT   27-MAR-2024, entry version 33.
DE   RecName: Full=phosphoinositide 5-phosphatase {ECO:0000256|ARBA:ARBA00013044};
DE            EC=3.1.3.36 {ECO:0000256|ARBA:ARBA00013044};
GN   ORFNames=TCLT_LOCUS5931 {ECO:0000313|EMBL:VDN03233.1};
OS   Thelazia callipaeda (Oriental eyeworm) (Parasitic nematode).
OC   Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC   Spirurina; Spiruromorpha; Thelazioidea; Thelaziidae; Thelazia.
OX   NCBI_TaxID=103827 {ECO:0000313|Proteomes:UP000046394, ECO:0000313|WBParaSite:TCLT_0000594201-mRNA-1};
RN   [1] {ECO:0000313|WBParaSite:TCLT_0000594201-mRNA-1}
RP   IDENTIFICATION.
RG   WormBaseParasite;
RL   Submitted (FEB-2017) to UniProtKB.
RN   [2] {ECO:0000313|EMBL:VDN03233.1, ECO:0000313|Proteomes:UP000276776}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RG   Pathogen Informatics;
RL   Submitted (NOV-2018) to the EMBL/GenBank/DDBJ databases.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-4,5-
CC         bisphosphate) + H2O = a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-
CC         inositol 4-phosphate) + phosphate; Xref=Rhea:RHEA:22764,
CC         ChEBI:CHEBI:15377, ChEBI:CHEBI:43474, ChEBI:CHEBI:58178,
CC         ChEBI:CHEBI:58456; EC=3.1.3.36;
CC         Evidence={ECO:0000256|ARBA:ARBA00001786};
CC   -!- SIMILARITY: Belongs to the synaptojanin family.
CC       {ECO:0000256|ARBA:ARBA00008943}.
CC   -!- SIMILARITY: In the central section; belongs to the inositol 1,4,5-
CC       trisphosphate 5-phosphatase family. {ECO:0000256|ARBA:ARBA00009678}.
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DR   EMBL; UYYF01004374; VDN03233.1; -; Genomic_DNA.
DR   STRING; 103827.A0A0N5CZL4; -.
DR   WBParaSite; TCLT_0000594201-mRNA-1; TCLT_0000594201-mRNA-1; TCLT_0000594201.
DR   OMA; HPCHELR; -.
DR   Proteomes; UP000046394; Unplaced.
DR   Proteomes; UP000276776; Unassembled WGS sequence.
DR   GO; GO:0004439; F:phosphatidylinositol-4,5-bisphosphate 5-phosphatase activity; IEA:UniProtKB-EC.
DR   GO; GO:0046856; P:phosphatidylinositol dephosphorylation; IEA:InterPro.
DR   Gene3D; 3.30.70.330; -; 1.
DR   Gene3D; 3.60.10.10; Endonuclease/exonuclease/phosphatase; 1.
DR   InterPro; IPR036691; Endo/exonu/phosph_ase_sf.
DR   InterPro; IPR005135; Endo/exonuclease/phosphatase.
DR   InterPro; IPR046985; IP5.
DR   InterPro; IPR000300; IPPc.
DR   InterPro; IPR012677; Nucleotide-bd_a/b_plait_sf.
DR   InterPro; IPR002013; SAC_dom.
DR   InterPro; IPR015047; SYNJ1/2_RRM.
DR   PANTHER; PTHR11200; INOSITOL 5-PHOSPHATASE; 1.
DR   PANTHER; PTHR11200:SF257; PHOSPHOINOSITIDE 5-PHOSPHATASE; 1.
DR   Pfam; PF08952; DUF1866; 1.
DR   Pfam; PF03372; Exo_endo_phos; 1.
DR   Pfam; PF02383; Syja_N; 1.
DR   SMART; SM01165; DUF1866; 1.
DR   SMART; SM00128; IPPc; 1.
DR   SUPFAM; SSF56219; DNase I-like; 1.
DR   PROSITE; PS50275; SAC; 1.
PE   3: Inferred from homology;
KW   Reference proteome {ECO:0000313|Proteomes:UP000276776}.
FT   DOMAIN          121..435
FT                   /note="SAC"
FT                   /evidence="ECO:0000259|PROSITE:PS50275"
SQ   SEQUENCE   1064 AA;  120173 MW;  C0C2D5956992639E CRC64;
     MSHRSAIRIA YRDVSTEPYS VIVDSQRTGK ILLFQSSAVT TISDRESVSA LRKNHAKLMD
     ARGLVGVLRS GQDDAYLIAV TEDENVGELR SCKIYRIWSV NVISLKVTTP VNSTDTKIND
     LLRLFSSGNF YYASQDDSSR FVDLTIRSHK SINSLDGDKK IYRNKHLHFP LKRYGVDANE
     WLLRIICGAV VICQVYVGQV RATVALISRL SCERVGTRFN VRGVNDDGHV ANFVETEQII
     ALGPDETSFV QIRGSVPLFW EQPGINVGSH KVKLRAFEAS SPAFIRHFRF LKDEYGEITI
     VNLLGSKEGE ILLSRAYEAH YKNSNCCTDY ITFDYHEEKR NCWKLLERLN STITKCMFYQ
     QRNGNAVVNQ IGAIRVNCLD CLDRTNAVQT LIGLQVLISQ LKNLGVDKKY FSRFEERLKE
     IWQRNGDSCS VIYAGTGALE GKSKMKDARR TLVRTIQNNF LDAAKQEAFE FLLNESSVYD
     PLYSELTSMV PRHILQECPL IVKDLMKRKE EMIDMVPLIL WAGTWNVNGG KNFSDTSFRN
     QTNLAEWLFP EKFFGDTLGE NIALPDIYVV GLEEIIDLNA TNIVNASTTN QRAWARGLRE
     TLLKRNKYVL LGCEQLVGVC VFVFIRPSLA AAIRDMSISS VKTGMGGTTG NKGSIAVSLT
     IYSTTFCFVC SHLAAGQNEV RDRNEDYMSA LKKIRFPQGR SILSHVVVFW MGDFNYRINL
     SRDEAEAAIK TGNMMELFRY DQLSQQKALG EVFKNFKEGP LIFAPTYKYD TLSDEYDSSE
     KCRIPAWTDR ILWKEADDSK VVRLLGYDRI ELRTSDHRPV CALFLVDAYK INLTQFGLVF
     KDVLSSMGPP DATVLVSVCG CENFPAEFRV SVIEKLDQLG ISPSISKIES GMLWLIFNSC
     DMALAALSLD GVKIGNHSLT VQLLSPDWAE VEYAELIKML RNVKEDISVE FIEFRNADNF
     EISDGDDVLI KNESDVHQLP KQRSASLNRR DKDLTLPSLP NATFTSVSSP LPNDNQIYGP
     LNDIMLINSI SPALPRVRQL PRSEEFNLMC IPPPIPPRKD SVRK
//