ID   A0A0N5CZM6_THECL        Unreviewed;       951 AA.
AC   A0A0N5CZM6;
DT   09-DEC-2015, integrated into UniProtKB/TrEMBL.
DT   09-DEC-2015, sequence version 1.
DT   27-MAR-2024, entry version 26.
DE   SubName: Full=Macoilin {ECO:0000313|WBParaSite:TCLT_0000595401-mRNA-1};
GN   ORFNames=TCLT_LOCUS5943 {ECO:0000313|EMBL:VDN03247.1};
OS   Thelazia callipaeda (Oriental eyeworm) (Parasitic nematode).
OC   Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC   Spirurina; Spiruromorpha; Thelazioidea; Thelaziidae; Thelazia.
OX   NCBI_TaxID=103827 {ECO:0000313|Proteomes:UP000046394, ECO:0000313|WBParaSite:TCLT_0000595401-mRNA-1};
RN   [1] {ECO:0000313|WBParaSite:TCLT_0000595401-mRNA-1}
RP   IDENTIFICATION.
RG   WormBaseParasite;
RL   Submitted (FEB-2017) to UniProtKB.
RN   [2] {ECO:0000313|EMBL:VDN03247.1, ECO:0000313|Proteomes:UP000276776}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RG   Pathogen Informatics;
RL   Submitted (NOV-2018) to the EMBL/GenBank/DDBJ databases.
CC   -!- SUBCELLULAR LOCATION: Endoplasmic reticulum membrane
CC       {ECO:0000256|ARBA:ARBA00004477}; Multi-pass membrane protein
CC       {ECO:0000256|ARBA:ARBA00004477}. Membrane
CC       {ECO:0000256|ARBA:ARBA00004141}; Multi-pass membrane protein
CC       {ECO:0000256|ARBA:ARBA00004141}. Nucleus membrane
CC       {ECO:0000256|ARBA:ARBA00004232}; Multi-pass membrane protein
CC       {ECO:0000256|ARBA:ARBA00004232}. Rough endoplasmic reticulum membrane
CC       {ECO:0000256|ARBA:ARBA00004269}; Multi-pass membrane protein
CC       {ECO:0000256|ARBA:ARBA00004269}.
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DR   EMBL; UYYF01004375; VDN03247.1; -; Genomic_DNA.
DR   STRING; 103827.A0A0N5CZM6; -.
DR   WBParaSite; TCLT_0000595401-mRNA-1; TCLT_0000595401-mRNA-1; TCLT_0000595401.
DR   OMA; VCLPTVM; -.
DR   Proteomes; UP000046394; Unplaced.
DR   Proteomes; UP000276776; Unassembled WGS sequence.
DR   GO; GO:0031965; C:nuclear membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0030867; C:rough endoplasmic reticulum membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0023041; P:neuronal signal transduction; IEA:InterPro.
DR   InterPro; IPR019130; Macoilin.
DR   PANTHER; PTHR13289:SF6; MACOILIN; 1.
DR   PANTHER; PTHR13289; PROTEIN PHOSPHATASE 1-BINDING PROTEIN BIFOCAL; 1.
DR   Pfam; PF09726; Macoilin; 3.
PE   4: Predicted;
KW   Coiled coil {ECO:0000256|SAM:Coils};
KW   Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW   Nucleus {ECO:0000256|ARBA:ARBA00023242};
KW   Reference proteome {ECO:0000313|Proteomes:UP000276776};
KW   Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW   ECO:0000256|SAM:Phobius}.
FT   TRANSMEM        42..66
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        78..100
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        106..128
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   REGION          334..390
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          440..502
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          895..929
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COILED          615..740
FT                   /evidence="ECO:0000256|SAM:Coils"
FT   COILED          781..822
FT                   /evidence="ECO:0000256|SAM:Coils"
FT   COMPBIAS        334..368
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        453..493
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   951 AA;  106180 MW;  9AB28ED59D9E4F51 CRC64;
     MMKRTGRTFD LPKIRRNMKG RGRISETMCC GHFSGVAYVK LVLLWLGCIA LDLLIGFRFE
     LLYPVWLLMR RCYESFRFHG LISTLHYSTY SVFFVCATVT TDLICFIFLP FQLLFFLAST
     YVWILLVWQT ADRGIGSTQF LLWFTLIAFE YNWRYRGDSP LQILKGSSLA STLNFLTGGL
     LANSLGLQDV SIGGEIVESD LSKDCSTSAR FSNSASGILD SLGVALMTAF THSSSLSSDF
     CRPFAAHCIG YPVVTLGFGL KTYIKLWRVK RRRLEVSRAN EVYCKLLTEA LPMLYDDPKL
     YARSSDTITH DQIEYEADVS LSGTQNLAIC GSSSPLTQTH RKNSRAGMVS KQNSKHSGTC
     SKKNTVSGGS APARKGKVVQ GSNCDDDSSS SVSLLVTSRM YLWRIVWEVI YGIVLHIFGI
     IFESPSLVVD DRVSLSSNEV GSDDEVIELE ETSSQPDDTS PYSNRLSSRQ RPTTSSKKSK
     MLIPSSRSFS QAKGGRSRGR HLQNHTDCVL SPLTSSSALT STSLGANCAF NNNLLNLAAG
     SVQQDRHMYS STSNTALQSS GSAGNEVVEN SVPSGMSASA NNGKTSEHYI SETLETMRSE
     LRAARSQETE LRSIIQQYVI EERQLKGELQ QLKLKQEQSD NKLASLMKAR EQDKSAIQQL
     EKKLIDAQTK RNEVEKELNA ERRKAKEEHD AARLAAAQFV KNFECGEMCK ARRADMEKDL
     RIVRRELKIK EELINSHEEE LRQLRYFKEN NDIKELHATL RAIREKNIHL EKSLSAENRL
     KQELFRALSE ARGQMAEFQQ QLRLKDADLR SKQAELMNLR ERIGGETDNA AKLCSVGDNR
     PSLSVKSPRC VSSGSSMSPS IVTDINSVMK SSVTAEQQIF NTVFRPYTFN TQTSEEEHSL
     FDNPIARSPP APSCPVSRPS SSRLSSVSSD SFHFAGNRFS LKSGNTDPSR P
//