ID   A0A0N5D269_THECL        Unreviewed;       986 AA.
AC   A0A0N5D269;
DT   09-DEC-2015, integrated into UniProtKB/TrEMBL.
DT   09-DEC-2015, sequence version 1.
DT   27-MAR-2024, entry version 35.
DE   RecName: Full=RNA helicase {ECO:0000256|ARBA:ARBA00012552};
DE            EC=3.6.4.13 {ECO:0000256|ARBA:ARBA00012552};
GN   ORFNames=TCLT_LOCUS6956 {ECO:0000313|EMBL:VDN04364.1};
OS   Thelazia callipaeda (Oriental eyeworm) (Parasitic nematode).
OC   Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC   Spirurina; Spiruromorpha; Thelazioidea; Thelaziidae; Thelazia.
OX   NCBI_TaxID=103827 {ECO:0000313|Proteomes:UP000046394, ECO:0000313|WBParaSite:TCLT_0000696701-mRNA-1};
RN   [1] {ECO:0000313|WBParaSite:TCLT_0000696701-mRNA-1}
RP   IDENTIFICATION.
RG   WormBaseParasite;
RL   Submitted (FEB-2017) to UniProtKB.
RN   [2] {ECO:0000313|EMBL:VDN04364.1, ECO:0000313|Proteomes:UP000276776}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RG   Pathogen Informatics;
RL   Submitted (NOV-2018) to the EMBL/GenBank/DDBJ databases.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=ATP + H2O = ADP + H(+) + phosphate; Xref=Rhea:RHEA:13065,
CC         ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:30616,
CC         ChEBI:CHEBI:43474, ChEBI:CHEBI:456216; EC=3.6.4.13;
CC         Evidence={ECO:0000256|ARBA:ARBA00001556};
CC   -!- SIMILARITY: Belongs to the DEAD box helicase family. DEAH subfamily.
CC       {ECO:0000256|ARBA:ARBA00008792}.
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DR   EMBL; UYYF01004461; VDN04364.1; -; Genomic_DNA.
DR   STRING; 103827.A0A0N5D269; -.
DR   WBParaSite; TCLT_0000696701-mRNA-1; TCLT_0000696701-mRNA-1; TCLT_0000696701.
DR   OMA; NICAREA; -.
DR   Proteomes; UP000046394; Unplaced.
DR   Proteomes; UP000276776; Unassembled WGS sequence.
DR   GO; GO:0016787; F:hydrolase activity; IEA:UniProtKB-KW.
DR   GO; GO:0003723; F:RNA binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0003724; F:RNA helicase activity; IEA:UniProtKB-EC.
DR   CDD; cd18791; SF2_C_RHA; 1.
DR   Gene3D; 1.20.120.1080; -; 1.
DR   Gene3D; 3.30.160.20; -; 1.
DR   Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 2.
DR   InterPro; IPR011709; DEAD-box_helicase_OB_fold.
DR   InterPro; IPR002464; DNA/RNA_helicase_DEAH_CS.
DR   InterPro; IPR014720; dsRBD_dom.
DR   InterPro; IPR048333; HA2_WH.
DR   InterPro; IPR007502; Helicase-assoc_dom.
DR   InterPro; IPR014001; Helicase_ATP-bd.
DR   InterPro; IPR001650; Helicase_C.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   PANTHER; PTHR18934; ATP-DEPENDENT RNA HELICASE; 1.
DR   PANTHER; PTHR18934:SF119; ATP-DEPENDENT RNA HELICASE A; 1.
DR   Pfam; PF04408; HA2_N; 1.
DR   Pfam; PF00271; Helicase_C; 1.
DR   Pfam; PF07717; OB_NTP_bind; 1.
DR   SMART; SM00487; DEXDc; 1.
DR   SMART; SM00847; HA2; 1.
DR   SMART; SM00490; HELICc; 1.
DR   SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR   PROSITE; PS00690; DEAH_ATP_HELICASE; 1.
DR   PROSITE; PS50137; DS_RBD; 1.
DR   PROSITE; PS51192; HELICASE_ATP_BIND_1; 1.
DR   PROSITE; PS51194; HELICASE_CTER; 1.
PE   3: Inferred from homology;
KW   ATP-binding {ECO:0000256|ARBA:ARBA00022806};
KW   Helicase {ECO:0000256|ARBA:ARBA00022806};
KW   Hydrolase {ECO:0000256|ARBA:ARBA00022801};
KW   Nucleotide-binding {ECO:0000256|ARBA:ARBA00022806};
KW   Reference proteome {ECO:0000313|Proteomes:UP000276776};
KW   RNA-binding {ECO:0000256|PROSITE-ProRule:PRU00266}.
FT   DOMAIN          26..52
FT                   /note="DRBM"
FT                   /evidence="ECO:0000259|PROSITE:PS50137"
FT   DOMAIN          194..360
FT                   /note="Helicase ATP-binding"
FT                   /evidence="ECO:0000259|PROSITE:PS51192"
FT   DOMAIN          437..611
FT                   /note="Helicase C-terminal"
FT                   /evidence="ECO:0000259|PROSITE:PS51194"
SQ   SEQUENCE   986 AA;  110209 MW;  9561AF6CD62031CF CRC64;
     MHSCKKLNIH HLITTLHPLA LKMKAFSAEA KGSTKKAAKA ICALSLLQQL FDNHLIDSSD
     SKKNKSSVKN LPKIPVNVSD KISREIMEYL KLVGVNEARL PSSLSEPVSL LITQKLNHFE
     TSDLVSESCV LWSPALPNWN PWKSVSIDET PLASMSLEEI STALLDQEKK KFVQPHIKAQ
     RRSLPVFQFR SHLIDTIGNN QITLIKGETG CGKSTQVCQY LLENYLENGR GSEFAAFITQ
     PRKLSATTLA ERVAVERGED LGKSVGYSVR FDSFPPRPYG SMMFVTVGVL LKRLEFGLCG
     ISHVIVDEIH ERDINTDVIL IILRDMMKIY PDLRVVLMSA SIDTKIFTNY FDGCGVVVIE
     GRRFPVQYYF LEDIIQMIQF SPSTSKSKKK QKYECDEDGQ EPTEEVQNLN LISGDEYNSN
     TKLAMSLLSE REIPFELIEA LLIDIAKEGE KGAVLIFLPS WSAIQCMLNI LRAHSLFGDK
     LRFAILPLHS RLAKQEQHKV FDHYSADVRK IILSTNIAET SVTIDDIVYV IDSCKTREKV
     YTSHNNMVHY VTDWSSRTNV IQRRGRAGRL REGFCFHLCS KSRFAALEEH QKPEILKIPL
     HEIALSIKLI GLGSVGDFLA KAIEAPPVSS VIEAERLLQE MSALDASNEL TPLGRLLAKL
     PVEPVFGKTL ILATVLGVGD LFATLSAASS LAAPYVVHCG ASSISSQHRT FAGTRFSDHV
     ALLCIYDKWR KMKSVMAEKD FCERLSLSSA VLKMISNVRR QMIDILISSG FHNSLFMPVD
     ICSQGYDKNI DLVLSLLVYA LYPNIGHLRD ERRVFTLEKT TALISKHSVN TSLDSTNTIK
     FPSPLFVFSE KIRTNIISCN QISNITPIQL LLFGGCKVEY HGDNIIKLDN IISLEMDVQA
     ASRIVALRPC IEALVVKACL NPQACSSLPE NSDSKLIALL EKLSSNFGWS SHPQEKLDEA
     QQICGSVETI SRTNCMRDNF NSKKDC
//