ID   A0A0N5D2M8_THECL        Unreviewed;       603 AA.
AC   A0A0N5D2M8;
DT   09-DEC-2015, integrated into UniProtKB/TrEMBL.
DT   09-DEC-2015, sequence version 1.
DT   27-MAR-2024, entry version 31.
DE   SubName: Full=Ras-GEF domain-containing protein {ECO:0000313|WBParaSite:TCLT_0000714501-mRNA-1};
GN   ORFNames=TCLT_LOCUS7134 {ECO:0000313|EMBL:VDN04562.1};
OS   Thelazia callipaeda (Oriental eyeworm) (Parasitic nematode).
OC   Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC   Spirurina; Spiruromorpha; Thelazioidea; Thelaziidae; Thelazia.
OX   NCBI_TaxID=103827 {ECO:0000313|Proteomes:UP000046394, ECO:0000313|WBParaSite:TCLT_0000714501-mRNA-1};
RN   [1] {ECO:0000313|WBParaSite:TCLT_0000714501-mRNA-1}
RP   IDENTIFICATION.
RG   WormBaseParasite;
RL   Submitted (FEB-2017) to UniProtKB.
RN   [2] {ECO:0000313|EMBL:VDN04562.1, ECO:0000313|Proteomes:UP000276776}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RG   Pathogen Informatics;
RL   Submitted (NOV-2018) to the EMBL/GenBank/DDBJ databases.
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DR   EMBL; UYYF01004478; VDN04562.1; -; Genomic_DNA.
DR   AlphaFoldDB; A0A0N5D2M8; -.
DR   STRING; 103827.A0A0N5D2M8; -.
DR   WBParaSite; TCLT_0000714501-mRNA-1; TCLT_0000714501-mRNA-1; TCLT_0000714501.
DR   OMA; PERAMPK; -.
DR   Proteomes; UP000046394; Unplaced.
DR   Proteomes; UP000276776; Unassembled WGS sequence.
DR   GO; GO:0005085; F:guanyl-nucleotide exchange factor activity; IEA:UniProtKB-KW.
DR   GO; GO:0007264; P:small GTPase mediated signal transduction; IEA:InterPro.
DR   Gene3D; 2.30.29.30; Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB); 1.
DR   Gene3D; 1.10.840.10; Ras guanine-nucleotide exchange factors catalytic domain; 1.
DR   InterPro; IPR011993; PH-like_dom_sf.
DR   InterPro; IPR008937; Ras-like_GEF.
DR   InterPro; IPR023578; Ras_GEF_dom_sf.
DR   InterPro; IPR001895; RASGEF_cat_dom.
DR   InterPro; IPR036964; RASGEF_cat_dom_sf.
DR   PANTHER; PTHR23113; GUANINE NUCLEOTIDE EXCHANGE FACTOR; 1.
DR   PANTHER; PTHR23113:SF368; RAS-GEF DOMAIN-CONTAINING PROTEIN; 1.
DR   Pfam; PF00617; RasGEF; 1.
DR   SMART; SM00147; RasGEF; 1.
DR   SUPFAM; SSF50729; PH domain-like; 1.
DR   SUPFAM; SSF48366; Ras GEF; 1.
DR   PROSITE; PS50009; RASGEF_CAT; 1.
PE   4: Predicted;
KW   Guanine-nucleotide releasing factor {ECO:0000256|ARBA:ARBA00022658,
KW   ECO:0000256|PROSITE-ProRule:PRU00168};
KW   Reference proteome {ECO:0000313|Proteomes:UP000276776}.
FT   DOMAIN          25..251
FT                   /note="Ras-GEF"
FT                   /evidence="ECO:0000259|PROSITE:PS50009"
SQ   SEQUENCE   603 AA;  69674 MW;  2157B135B0320254 CRC64;
     MKDDNHYLMY QKECDPVTID LLKVRPEDIA SQITLIDIPL FKAITAQELL KGGWGKKNKH
     LDASNIVSFT DRFNSVCLWC QREILSYEKT TKRTEVLEHF IKIAKQLYIL NNLHSTFSII
     SALQSLSIHR LVKTWSLISR PERAVFTNLK LLFESECNWK RLREHLNSAE LPCIPYIGLY
     LTDLSFIDAA SCVVKKTYTV SLNKERKKKD IISRISYFQK SLYDNLTHIE CLQKYLNSLQ
     FHEEFIKFEE DDLFKYLNIV SELLDYMIDI IIFIIHFEDS YHFKECKVFR LSLARENGSQ
     CASASSPAVE FLRRASLSRT MRVLNRFRSN FPSIEKITHT MTPQLPSKNH HHRAIVFGSR
     RARSLSAGWN TGEVNLSFPF DAESVDAEPF QDIESTESPD SNFASEKILR HTTYVVDSSS
     LGHTFSFTPL KTSTSLKCAP LLSPKARFRS FDNSGDQLCL IDDDDDDDTK VADYAGEVSV
     LTIRKKGSKL TKIKCSRKCY LELRSSQLYQ FSRRPVTILS KNDRDSYNKK ANKIMKLDEN
     GWRVIHHINL PEPSFEMHHP PTGSRIYRYI CKNETAALEW YKHIQAAIQD ALSSVPSTLI
     TFD
//