ID   A0A0N5D3V7_THECL        Unreviewed;       432 AA.
AC   A0A0N5D3V7;
DT   09-DEC-2015, integrated into UniProtKB/TrEMBL.
DT   09-DEC-2015, sequence version 1.
DT   27-MAR-2024, entry version 29.
DE   SubName: Full=Reduced folate carrier family protein {ECO:0000313|WBParaSite:TCLT_0000762701-mRNA-1};
GN   ORFNames=TCLT_LOCUS7616 {ECO:0000313|EMBL:VDN05091.1};
OS   Thelazia callipaeda (Oriental eyeworm) (Parasitic nematode).
OC   Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC   Spirurina; Spiruromorpha; Thelazioidea; Thelaziidae; Thelazia.
OX   NCBI_TaxID=103827 {ECO:0000313|Proteomes:UP000046394, ECO:0000313|WBParaSite:TCLT_0000762701-mRNA-1};
RN   [1] {ECO:0000313|WBParaSite:TCLT_0000762701-mRNA-1}
RP   IDENTIFICATION.
RG   WormBaseParasite;
RL   Submitted (FEB-2017) to UniProtKB.
RN   [2] {ECO:0000313|EMBL:VDN05091.1, ECO:0000313|Proteomes:UP000276776}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RG   Pathogen Informatics;
RL   Submitted (NOV-2018) to the EMBL/GenBank/DDBJ databases.
CC   -!- SIMILARITY: Belongs to the reduced folate carrier (RFC) transporter (TC
CC       2.A.48) family. {ECO:0000256|ARBA:ARBA00005773}.
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DR   EMBL; UYYF01004528; VDN05091.1; -; Genomic_DNA.
DR   WBParaSite; TCLT_0000762701-mRNA-1; TCLT_0000762701-mRNA-1; TCLT_0000762701.
DR   OMA; VQVLWKV; -.
DR   Proteomes; UP000046394; Unplaced.
DR   Proteomes; UP000276776; Unassembled WGS sequence.
DR   GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR   GO; GO:0090482; F:vitamin transmembrane transporter activity; IEA:InterPro.
DR   InterPro; IPR002666; Folate_carrier.
DR   InterPro; IPR036259; MFS_trans_sf.
DR   NCBIfam; TIGR00806; rfc; 1.
DR   PANTHER; PTHR10686; FOLATE TRANSPORTER; 1.
DR   PANTHER; PTHR10686:SF18; FOLATE-LIKE TRANSPORTER 3; 1.
DR   Pfam; PF01770; Folate_carrier; 1.
DR   SUPFAM; SSF103473; MFS general substrate transporter; 1.
PE   3: Inferred from homology;
KW   Membrane {ECO:0000256|SAM:Phobius};
KW   Reference proteome {ECO:0000313|Proteomes:UP000276776};
KW   Transmembrane {ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM        49..67
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        99..118
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        138..157
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        163..184
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        276..296
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        342..368
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        383..406
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
SQ   SEQUENCE   432 AA;  50033 MW;  B8215BDBFB6ADDE0 CRC64;
     MWRFFTIFIC LYGFMKELKV GEPFLYLYQN EVLNLTREQL TNEVYPFSAY SYLLSLIPIF
     LLTDLLLYKP VMLLEVIGQT IYRGVLVFCP TVEAQKLGMM MYGMASASEI AFFSYIYAKT
     EKDEYQRVTS YSRASTMAGR MICYLSAQTV ILTRIGNYET LQWIGFGVPC CAVIFAIFLP
     NVYWKEILLK LTDSTNRTSI VERIELPKTY GAYLKYRLHV MRNELVRIYQ IDAIRKWSIW
     WALNTCMSLQ VAQYAQVLWG EVQGRNERSL NGFAEAAYAA SATIAILILG LAEINWDKWG
     ELMLAVISLT DTLILIVYSQ AESIQVMYMC YIGYRWNLAK KMIGESFGLI FGLNSFIALT
     LQVLLTIIVP DHHGLNMPVR KQFMVYAGCH AFIGTIFLTS LGYSLYRHYR WKERIHTEQC
     QKHTLHEQKV IA
//