ID A0A0N5D5A2_THECL Unreviewed; 643 AA.
AC A0A0N5D5A2;
DT 09-DEC-2015, integrated into UniProtKB/TrEMBL.
DT 08-JUN-2016, sequence version 2.
DT 27-MAR-2024, entry version 37.
DE RecName: Full=Ribosome biogenesis protein BOP1 homolog {ECO:0000256|HAMAP-Rule:MF_03027};
GN ORFNames=TCLT_LOCUS8169 {ECO:0000313|EMBL:VDN05697.1};
OS Thelazia callipaeda (Oriental eyeworm) (Parasitic nematode).
OC Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC Spirurina; Spiruromorpha; Thelazioidea; Thelaziidae; Thelazia.
OX NCBI_TaxID=103827 {ECO:0000313|Proteomes:UP000046394, ECO:0000313|WBParaSite:TCLT_0000818001-mRNA-1};
RN [1] {ECO:0000313|WBParaSite:TCLT_0000818001-mRNA-1}
RP IDENTIFICATION.
RG WormBaseParasite;
RL Submitted (APR-2016) to UniProtKB.
RN [2] {ECO:0000313|EMBL:VDN05697.1, ECO:0000313|Proteomes:UP000276776}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RG Pathogen Informatics;
RL Submitted (NOV-2018) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: Required for maturation of ribosomal RNAs and formation of
CC the large ribosomal subunit. {ECO:0000256|HAMAP-Rule:MF_03027}.
CC -!- SUBCELLULAR LOCATION: Nucleus, nucleolus {ECO:0000256|HAMAP-
CC Rule:MF_03027}. Nucleus, nucleoplasm {ECO:0000256|HAMAP-Rule:MF_03027}.
CC -!- SIMILARITY: Belongs to the WD repeat BOP1/ERB1 family.
CC {ECO:0000256|HAMAP-Rule:MF_03027}.
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DR EMBL; UYYF01004593; VDN05697.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A0N5D5A2; -.
DR STRING; 103827.A0A0N5D5A2; -.
DR WBParaSite; TCLT_0000818001-mRNA-1; TCLT_0000818001-mRNA-1; TCLT_0000818001.
DR OMA; MRPAKGE; -.
DR Proteomes; UP000046394; Unplaced.
DR Proteomes; UP000276776; Unassembled WGS sequence.
DR GO; GO:0005730; C:nucleolus; IEA:UniProtKB-SubCell.
DR GO; GO:0005654; C:nucleoplasm; IEA:UniProtKB-SubCell.
DR GO; GO:0030687; C:preribosome, large subunit precursor; IEA:UniProtKB-UniRule.
DR GO; GO:0043021; F:ribonucleoprotein complex binding; IEA:UniProtKB-UniRule.
DR GO; GO:0000466; P:maturation of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA); IEA:UniProtKB-UniRule.
DR GO; GO:0000463; P:maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA); IEA:UniProtKB-UniRule.
DR Gene3D; 2.130.10.10; YVTN repeat-like/Quinoprotein amine dehydrogenase; 1.
DR HAMAP; MF_03027; BOP1; 1.
DR InterPro; IPR028598; BOP1/Erb1.
DR InterPro; IPR012953; BOP1_N_dom.
DR InterPro; IPR015943; WD40/YVTN_repeat-like_dom_sf.
DR InterPro; IPR036322; WD40_repeat_dom_sf.
DR InterPro; IPR001680; WD40_rpt.
DR PANTHER; PTHR17605:SF0; RIBOSOME BIOGENESIS PROTEIN BOP1; 1.
DR PANTHER; PTHR17605; RIBOSOME BIOGENESIS PROTEIN BOP1 BLOCK OF PROLIFERATION 1 PROTEIN; 1.
DR Pfam; PF08145; BOP1NT; 1.
DR Pfam; PF00400; WD40; 3.
DR SMART; SM01035; BOP1NT; 1.
DR SMART; SM00320; WD40; 6.
DR SUPFAM; SSF50978; WD40 repeat-like; 1.
DR PROSITE; PS50082; WD_REPEATS_2; 1.
DR PROSITE; PS50294; WD_REPEATS_REGION; 1.
PE 3: Inferred from homology;
KW Nucleus {ECO:0000256|ARBA:ARBA00023242, ECO:0000256|HAMAP-Rule:MF_03027};
KW Reference proteome {ECO:0000313|Proteomes:UP000276776};
KW Ribosome biogenesis {ECO:0000256|ARBA:ARBA00022517, ECO:0000256|HAMAP-
KW Rule:MF_03027};
KW rRNA processing {ECO:0000256|ARBA:ARBA00022552, ECO:0000256|HAMAP-
KW Rule:MF_03027}; WD repeat {ECO:0000256|PROSITE-ProRule:PRU00221}.
FT DOMAIN 42..303
FT /note="BOP1 N-terminal"
FT /evidence="ECO:0000259|SMART:SM01035"
FT REPEAT 310..352
FT /note="WD"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00221"
SQ SEQUENCE 643 AA; 74183 MW; 07A111132F535207 CRC64;
MVYKRASNLQ EEKEVRQVAD YYDSSDEEDL RNTIGNIPVA WYDGLDHFGY DKDGNPIKSA
KKKDEIEEFL DRMDDPNYWR KVYDQQSGGF VTLSDEQVEQ LNALNASKYP TIGYNPYQPF
LDIFSSQTEI HPISNRPDSK SSFIPSIHER RIVGKMIHAI KMGWVRPPKP KNAKKVIYDL
WADEPSKQKT KSELARIKMH FPAPKVALPG HAESYNPPEE YLFDEEEQKK WEETEPEDRR
LDFIPKKFDC LRKVPAYDRF YNDRYQRCLD LYLAPRQRKM KLNVDPAQLL PELPNLADMH
PFPTVLSFYM YGHIGQVRSI SFEYESTEIF ASGGEDSTLR IWSVCDGRCL KTTSLEGPVT
SVAYCPLMKW TLLAVTMESN KMILMNSHCG DRHRISSTTE YLSSLNPDLS GNNGLKWKHE
GKDRISVDIG HVARQVVWHH KGDYFATFAV SKSPKLIFIH QLSKCMSQRP FSRLKGIMTA
LSFHPQKPFL FVGTQRHIRI YDLAKCQLKK KIMTGSQWVS SMHIDFQGEN VFVGGHDRTF
SWIDLQLSSK PWKTVKHHSA AIRAIAQHPR YPLLATVSDD STAVIYYARI SSDPFKENEF
VPVRRLRVRT THKNSLSILS VVFHPSQPWL ITAQADGSIA LFT
//
