ID A0A0N5D5U5_THECL Unreviewed; 798 AA.
AC A0A0N5D5U5;
DT 09-DEC-2015, integrated into UniProtKB/TrEMBL.
DT 09-DEC-2015, sequence version 1.
DT 27-MAR-2024, entry version 36.
DE SubName: Full=Malic enzyme {ECO:0000313|WBParaSite:TCLT_0000838801-mRNA-1};
GN ORFNames=TCLT_LOCUS8377 {ECO:0000313|EMBL:VDN05931.1};
OS Thelazia callipaeda (Oriental eyeworm) (Parasitic nematode).
OC Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC Spirurina; Spiruromorpha; Thelazioidea; Thelaziidae; Thelazia.
OX NCBI_TaxID=103827 {ECO:0000313|Proteomes:UP000046394, ECO:0000313|WBParaSite:TCLT_0000838801-mRNA-1};
RN [1] {ECO:0000313|WBParaSite:TCLT_0000838801-mRNA-1}
RP IDENTIFICATION.
RG WormBaseParasite;
RL Submitted (FEB-2017) to UniProtKB.
RN [2] {ECO:0000313|EMBL:VDN05931.1, ECO:0000313|Proteomes:UP000276776}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RG Pathogen Informatics;
RL Submitted (NOV-2018) to the EMBL/GenBank/DDBJ databases.
CC -!- SIMILARITY: Belongs to the malic enzymes family.
CC {ECO:0000256|ARBA:ARBA00008785}.
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DR EMBL; UYYF01004623; VDN05931.1; -; Genomic_DNA.
DR STRING; 103827.A0A0N5D5U5; -.
DR WBParaSite; TCLT_0000838801-mRNA-1; TCLT_0000838801-mRNA-1; TCLT_0000838801.
DR OMA; YYRMLME; -.
DR Proteomes; UP000046394; Unplaced.
DR Proteomes; UP000276776; Unassembled WGS sequence.
DR GO; GO:0004470; F:malic enzyme activity; IEA:InterPro.
DR GO; GO:0051287; F:NAD binding; IEA:InterPro.
DR GO; GO:0016616; F:oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor; IEA:InterPro.
DR CDD; cd05312; NAD_bind_1_malic_enz; 1.
DR Gene3D; 3.40.50.10380; Malic enzyme, N-terminal domain; 1.
DR Gene3D; 3.40.50.720; NAD(P)-binding Rossmann-like Domain; 2.
DR InterPro; IPR046346; Aminoacid_DH-like_N_sf.
DR InterPro; IPR012301; Malic_N_dom.
DR InterPro; IPR037062; Malic_N_dom_sf.
DR InterPro; IPR012302; Malic_NAD-bd.
DR InterPro; IPR001891; Malic_OxRdtase.
DR InterPro; IPR036291; NAD(P)-bd_dom_sf.
DR PANTHER; PTHR23406; MALIC ENZYME-RELATED; 1.
DR PANTHER; PTHR23406:SF90; MALIC ENZYME-RELATED; 1.
DR Pfam; PF00390; malic; 1.
DR Pfam; PF03949; Malic_M; 2.
DR PRINTS; PR00072; MALOXRDTASE.
DR SMART; SM01274; malic; 1.
DR SMART; SM00919; Malic_M; 2.
DR SUPFAM; SSF53223; Aminoacid dehydrogenase-like, N-terminal domain; 1.
DR SUPFAM; SSF51735; NAD(P)-binding Rossmann-fold domains; 2.
PE 3: Inferred from homology;
KW Reference proteome {ECO:0000313|Proteomes:UP000276776}.
FT DOMAIN 1..128
FT /note="Malic enzyme NAD-binding"
FT /evidence="ECO:0000259|SMART:SM00919"
FT DOMAIN 303..486
FT /note="Malic enzyme N-terminal"
FT /evidence="ECO:0000259|SMART:SM01274"
FT DOMAIN 496..747
FT /note="Malic enzyme NAD-binding"
FT /evidence="ECO:0000259|SMART:SM00919"
SQ SEQUENCE 798 AA; 90683 MW; F5C9965CBC012517 CRC64;
MAKINENPII FALSNPTNKA ECTAEDAYRC TSGKVLFASG SPFSNVNYNG KIFKPGQGNN
AYIFPGVALG AILFNIRHID DETFLIAAHE VANCVTEKDF KVGRLYPRLN RIREVSVKIA
VAIGEYAYEI GMAGLYPKPE NMKQFVLSQI YQTTYDELID VTYDWPAHDM KHGFPVPVSR
RESVDDPASI RNIAKSAVLK QKHPNSADDE TIPEWCHSKN DIKLYMLYRH ERETPKKHGF
EILKDSRFCK GMAFSLYERQ HLGIHGLLPP AIMTEDQQAY RAILNLRKQP NDLARYVQLD
SLQERDEKLY YRVICNHVKE LLPIVYTPTV GLACQKYGFI YRRPKGLYIT IHDNSISKIY
HILSNWPEAD VRVMVVTDGE RILGLGDLGC YGMGIPVGKL ALYVALAGVL PKWCLPVVLD
VGTDNETLLK DPLYIGLRRK RVRGEDYDEF IDNFMKACTK KFGQKLLIHF EDFARQNAYR
LLDRYREKYC VFNDDIQGTA AAVLAGLLAC RQHTGRPLSA EKFIFLGAGA AAMGITELCI
SHMETEGVKR KKARSHIYLV DINGLITKNR LHMEKQHVPY AKDMPEITNL LELIKLIKPT
ALIGTSTTGG AFNEEIVRTM AEFNQKPIIF ALSNPTKKAE CTAEQAIKWT DGRVLFASGS
PFENVKYNGK LFKPGQGNNS YIYPAVGMAA ILFQIRHIDD NMFLIAAQEV AKSVSSDDYQ
CRRLYPSFSR IREVSLKIII ALGKYSYEKN MASLYPKPEN VENFVRSQMY NTNYDKIVDY
RYDWPEQDMV QGYPVPND
//
