ID   A0A0N5D790_THECL        Unreviewed;      1159 AA.
AC   A0A0N5D790;
DT   09-DEC-2015, integrated into UniProtKB/TrEMBL.
DT   08-JUN-2016, sequence version 2.
DT   27-MAR-2024, entry version 38.
DE   SubName: Full=TGF_BETA_2 domain-containing protein {ECO:0000313|WBParaSite:TCLT_0000892801-mRNA-1};
GN   ORFNames=TCLT_LOCUS8917 {ECO:0000313|EMBL:VDN06509.1};
OS   Thelazia callipaeda (Oriental eyeworm) (Parasitic nematode).
OC   Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC   Spirurina; Spiruromorpha; Thelazioidea; Thelaziidae; Thelazia.
OX   NCBI_TaxID=103827 {ECO:0000313|Proteomes:UP000046394, ECO:0000313|WBParaSite:TCLT_0000892801-mRNA-1};
RN   [1] {ECO:0000313|WBParaSite:TCLT_0000892801-mRNA-1}
RP   IDENTIFICATION.
RG   WormBaseParasite;
RL   Submitted (APR-2016) to UniProtKB.
RN   [2] {ECO:0000313|EMBL:VDN06509.1, ECO:0000313|Proteomes:UP000276776}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RG   Pathogen Informatics;
RL   Submitted (NOV-2018) to the EMBL/GenBank/DDBJ databases.
CC   -!- SIMILARITY: Belongs to the TGF-beta family.
CC       {ECO:0000256|ARBA:ARBA00006656, ECO:0000256|RuleBase:RU000354}.
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DR   EMBL; UYYF01004702; VDN06509.1; -; Genomic_DNA.
DR   AlphaFoldDB; A0A0N5D790; -.
DR   STRING; 103827.A0A0N5D790; -.
DR   WBParaSite; TCLT_0000892801-mRNA-1; TCLT_0000892801-mRNA-1; TCLT_0000892801.
DR   OMA; RMAEPCV; -.
DR   Proteomes; UP000046394; Unplaced.
DR   Proteomes; UP000276776; Unassembled WGS sequence.
DR   GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005777; C:peroxisome; IEA:UniProtKB-KW.
DR   GO; GO:0005524; F:ATP binding; IEA:InterPro.
DR   GO; GO:0016887; F:ATP hydrolysis activity; IEA:InterPro.
DR   GO; GO:0008083; F:growth factor activity; IEA:UniProtKB-KW.
DR   CDD; cd13761; TGF_beta_BMP5_like; 1.
DR   Gene3D; 1.10.8.60; -; 2.
DR   Gene3D; 2.60.120.970; -; 1.
DR   Gene3D; 2.10.90.10; Cystine-knot cytokines; 1.
DR   Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 2.
DR   InterPro; IPR003593; AAA+_ATPase.
DR   InterPro; IPR003959; ATPase_AAA_core.
DR   InterPro; IPR003960; ATPase_AAA_CS.
DR   InterPro; IPR029034; Cystine-knot_cytokine.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   InterPro; IPR001839; TGF-b_C.
DR   InterPro; IPR001111; TGF-b_propeptide.
DR   InterPro; IPR017948; TGFb_CS.
DR   PANTHER; PTHR23077; AAA-FAMILY ATPASE; 1.
DR   PANTHER; PTHR23077:SF9; PEROXISOME ASSEMBLY FACTOR 2; 1.
DR   Pfam; PF00004; AAA; 1.
DR   Pfam; PF00019; TGF_beta; 1.
DR   Pfam; PF00688; TGFb_propeptide; 1.
DR   SMART; SM00382; AAA; 1.
DR   SMART; SM00204; TGFB; 1.
DR   SUPFAM; SSF57501; Cystine-knot cytokines; 1.
DR   SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 2.
DR   PROSITE; PS00674; AAA; 1.
DR   PROSITE; PS00250; TGF_BETA_1; 1.
DR   PROSITE; PS51362; TGF_BETA_2; 1.
PE   3: Inferred from homology;
KW   Cytoplasm {ECO:0000256|ARBA:ARBA00022490};
KW   Growth factor {ECO:0000256|ARBA:ARBA00023030,
KW   ECO:0000256|RuleBase:RU000354}; Hydrolase {ECO:0000256|ARBA:ARBA00022801};
KW   Membrane {ECO:0000256|ARBA:ARBA00023136};
KW   Peroxisome {ECO:0000256|ARBA:ARBA00023140};
KW   Reference proteome {ECO:0000313|Proteomes:UP000276776};
KW   Signal {ECO:0000256|SAM:SignalP}.
FT   SIGNAL          1..24
FT                   /evidence="ECO:0000256|SAM:SignalP"
FT   CHAIN           25..1159
FT                   /evidence="ECO:0000256|SAM:SignalP"
FT                   /id="PRO_5035042084"
FT   DOMAIN          255..390
FT                   /note="TGF-beta family profile"
FT                   /evidence="ECO:0000259|PROSITE:PS51362"
SQ   SEQUENCE   1159 AA;  131387 MW;  7930280D0A8DCF2F CRC64;
     MNYCSRLQLI TIFFAICCVR VTRTSTGFYV DNENAQSIPL AVSRHGSARL ESKILELLGI
     KHSRPLVVRR KDDIVSRFMA DLYRNLEHDV ELNPAYKYLA SGQFLSADEK EAIELGEADT
     IVSFLPRDQN TVSNYGTSLR FNLADIPKSS QLLHAELRIF FNGSVKPWRV FATVQYPRNM
     GYLATIKSRI SSRGHFVLNI TEALLRWIQN EPAPAIVTLY AVTSHGDRRF LDSFGEWRGF
     GIASFVDVSN HLHQRVKRGI PDENAFENYG YGFSAKPDPL RHSASNKGCR RRTLYVDFKD
     LGWQDWVIAP DGYHAYYCDG FCSFPLNNHM NATNHAIVQT LVHLIDPTRT TEAKCAPSSL
     RSMKILFIDR SQNVVLKRYK NMQFVYYRGL YQNIQTLAVL AEFIMKQYSL ILRYLELVQF
     MLGTYIWLLW KNRSNCIKSY SDNIRIRLKV KSSRYGRHSC ETVVWISCRC AFMLMAGSKK
     MKKLIIKVCD GRSGKVAICC PKIYPLFCEQ PVAFIDDLSA FNLHTKGFCL ENTFLKVFPS
     DGLDGVKFCT SSEAHIALIR TSFYDHRIDY SNELRKYFLC PKLVSVGDVI VIHWRKPWNC
     EVMEIFFKIV SLDGPGKLSE AFIDSEKTTL FQSESIFNKI PYSNIRCYVP RKFLVLAQRI
     SSLIAANYTT KIMSPSLVIL LSGSPGSGKK LFLKYLSSVT HLDIYFANSF EIWSEASGIY
     KQNIRSTFEK ASNNPFSMLA FLNADLFGYN SGDTKQGLSV RFSARELTYL TELLETCNIP
     AIFLVCNDNK LSNLPISLRS LVLYHFEVPA LTEEDRVSVI KNELNSKNAI DITAISNQTT
     GFTLSDLHNL LSDALFRKRI SSSMTVETGH FMWAIGMRNT MLANEMKISK IPKTTWNDIG
     GLEDVKRVVT ESLLINLNKT NNMKRYGVLL YGPPGCGKTL IAKAVANEFK INFLSVKGPE
     LLNKYVGQSE ANVHQVFEKA RMAEPCVIFF DELDSLACIR GRFGDSSCVS DNIVSQLNIE
     LDCLEDFKVF VLGATNRLDL LDPSLLRPGR FDKIVEVSGT RDVVTRECIL RAAGRNIMFA
     NDVNLKEIAE LCRNLSSGAD LYAVILRAQA NALRKHIAAM EANLVSPKEH LLVTQSNLKE
     AVKEVLPSFP RTTKCSRRV
//