ID   A0A0N5D878_THECL        Unreviewed;       593 AA.
AC   A0A0N5D878;
DT   09-DEC-2015, integrated into UniProtKB/TrEMBL.
DT   09-DEC-2015, sequence version 1.
DT   27-MAR-2024, entry version 30.
DE   SubName: Full=PKD_channel domain-containing protein {ECO:0000313|WBParaSite:TCLT_0000930001-mRNA-1};
GN   ORFNames=TCLT_LOCUS9289 {ECO:0000313|EMBL:VDN06912.1};
OS   Thelazia callipaeda (Oriental eyeworm) (Parasitic nematode).
OC   Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC   Spirurina; Spiruromorpha; Thelazioidea; Thelaziidae; Thelazia.
OX   NCBI_TaxID=103827 {ECO:0000313|Proteomes:UP000046394, ECO:0000313|WBParaSite:TCLT_0000930001-mRNA-1};
RN   [1] {ECO:0000313|WBParaSite:TCLT_0000930001-mRNA-1}
RP   IDENTIFICATION.
RG   WormBaseParasite;
RL   Submitted (FEB-2017) to UniProtKB.
RN   [2] {ECO:0000313|EMBL:VDN06912.1, ECO:0000313|Proteomes:UP000276776}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RG   Pathogen Informatics;
RL   Submitted (NOV-2018) to the EMBL/GenBank/DDBJ databases.
CC   -!- SUBCELLULAR LOCATION: Endosome membrane
CC       {ECO:0000256|ARBA:ARBA00004337}; Multi-pass membrane protein
CC       {ECO:0000256|ARBA:ARBA00004337}. Membrane
CC       {ECO:0000256|ARBA:ARBA00004141}; Multi-pass membrane protein
CC       {ECO:0000256|ARBA:ARBA00004141}.
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DR   EMBL; UYYF01004766; VDN06912.1; -; Genomic_DNA.
DR   AlphaFoldDB; A0A0N5D878; -.
DR   STRING; 103827.A0A0N5D878; -.
DR   WBParaSite; TCLT_0000930001-mRNA-1; TCLT_0000930001-mRNA-1; TCLT_0000930001.
DR   OMA; WQARRKF; -.
DR   Proteomes; UP000046394; Unplaced.
DR   Proteomes; UP000276776; Unassembled WGS sequence.
DR   GO; GO:0010008; C:endosome membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005261; F:monoatomic cation channel activity; IEA:InterPro.
DR   CDD; cd21050; ELD_TRPML; 1.
DR   Gene3D; 1.10.287.70; -; 1.
DR   InterPro; IPR049134; MCLN_ECD.
DR   InterPro; IPR039031; Mucolipin.
DR   InterPro; IPR013122; PKD1_2_channel.
DR   PANTHER; PTHR12127; MUCOLIPIN; 1.
DR   PANTHER; PTHR12127:SF7; SD02261P; 1.
DR   Pfam; PF21381; MCLN_ECD; 1.
DR   Pfam; PF08016; PKD_channel; 1.
PE   4: Predicted;
KW   Cell membrane {ECO:0000256|ARBA:ARBA00022475};
KW   Disulfide bond {ECO:0000256|ARBA:ARBA00023157};
KW   Endosome {ECO:0000256|ARBA:ARBA00022753};
KW   Ion channel {ECO:0000256|ARBA:ARBA00023303};
KW   Ion transport {ECO:0000256|ARBA:ARBA00023065};
KW   Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW   Reference proteome {ECO:0000313|Proteomes:UP000276776};
KW   Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW   ECO:0000256|SAM:Phobius}; Transport {ECO:0000256|ARBA:ARBA00022448}.
FT   TRANSMEM        323..344
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        379..404
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        416..436
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        456..478
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        524..546
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   DOMAIN          96..304
FT                   /note="Mucolipin extracytosolic"
FT                   /evidence="ECO:0000259|Pfam:PF21381"
FT   DOMAIN          406..550
FT                   /note="Polycystin cation channel PKD1/PKD2"
FT                   /evidence="ECO:0000259|Pfam:PF08016"
SQ   SEQUENCE   593 AA;  68839 MW;  E10982F38F1B5F5E CRC64;
     MYCCKINFSS FANFLIEDVS RSVINFFSIS SKINLSDSDR ADGERLRRHL QFFFMDPMTK
     WKIRHQFPFK LALQILKIAF ISIQLLLFTE LRISHVDFMD DTNTVMRHKF LKNWNDERDT
     LTYPPSSGLY SVYTVIGRSD HIILFFSKLV FQYYSIQEDS FGSFSYDIPR NQDFGALPSL
     SFEDIPPMNF CLKRIANVTV FNNTYEFDVS EINDCVILKF DENEVKEVRR NSSSLRKFLE
     KRHITFKPED ALVISKGVIS FNLRTIHFTP ISIDKRPECF LIQVSIAFDN SRHTGQVHIY
     LTTVISYVTL CNGRVLHGIE FSIFVIIFVI DILVLLMCIA SFILCCRALV RAYLLKLVSF
     TFVKNVLKRE LQLNDQLDFL NLWYVMIVLN DIFIICGTLC KITIEFRDFD SDLFTTSGIL
     LGIGALMVYV GVLRYFGFFS KYNILILTIK KSVPNILRFM SCGAVLYTGF LIAGWVIIGP
     YSLKFRTLGK SSEALFSLLN GDDMFATFFT INDSNTAIKI FGTIYIYIFV SLFVYVVLSL
     FIAIIMDAYE VIKVYLQNNF FHCFNFYEIH TPVLSFCRFI YHVGKNLSNL FSF
//