ID A0A0N5D9G9_THECL Unreviewed; 707 AA.
AC A0A0N5D9G9;
DT 09-DEC-2015, integrated into UniProtKB/TrEMBL.
DT 08-JUN-2016, sequence version 2.
DT 27-MAR-2024, entry version 43.
DE SubName: Full=ADAM 17-like protease {ECO:0000313|WBParaSite:TCLT_0000977801-mRNA-1};
GN ORFNames=TCLT_LOCUS9767 {ECO:0000313|EMBL:VDN07423.1};
OS Thelazia callipaeda (Oriental eyeworm) (Parasitic nematode).
OC Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC Spirurina; Spiruromorpha; Thelazioidea; Thelaziidae; Thelazia.
OX NCBI_TaxID=103827 {ECO:0000313|Proteomes:UP000046394, ECO:0000313|WBParaSite:TCLT_0000977801-mRNA-1};
RN [1] {ECO:0000313|WBParaSite:TCLT_0000977801-mRNA-1}
RP IDENTIFICATION.
RG WormBaseParasite;
RL Submitted (APR-2016) to UniProtKB.
RN [2] {ECO:0000313|EMBL:VDN07423.1, ECO:0000313|Proteomes:UP000276776}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RG Pathogen Informatics;
RL Submitted (NOV-2018) to the EMBL/GenBank/DDBJ databases.
CC -!- COFACTOR:
CC Name=Zn(2+); Xref=ChEBI:CHEBI:29105;
CC Evidence={ECO:0000256|ARBA:ARBA00001947};
CC -!- CAUTION: Lacks conserved residue(s) required for the propagation of
CC feature annotation. {ECO:0000256|PROSITE-ProRule:PRU00276}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; UYYF01004875; VDN07423.1; -; Genomic_DNA.
DR STRING; 103827.A0A0N5D9G9; -.
DR WBParaSite; TCLT_0000977801-mRNA-1; TCLT_0000977801-mRNA-1; TCLT_0000977801.
DR OMA; NTTWNSE; -.
DR Proteomes; UP000046394; Unplaced.
DR Proteomes; UP000276776; Unassembled WGS sequence.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0004222; F:metalloendopeptidase activity; IEA:InterPro.
DR GO; GO:0006508; P:proteolysis; IEA:InterPro.
DR GO; GO:0050896; P:response to stimulus; IEA:UniProt.
DR CDD; cd14246; ADAM17_MPD; 1.
DR Gene3D; 4.10.70.30; -; 1.
DR Gene3D; 3.40.390.10; Collagenase (Catalytic Domain); 1.
DR Gene3D; 4.10.70.10; Disintegrin domain; 1.
DR InterPro; IPR032029; ADAM17_MPD.
DR InterPro; IPR001762; Disintegrin_dom.
DR InterPro; IPR036436; Disintegrin_dom_sf.
DR InterPro; IPR024079; MetalloPept_cat_dom_sf.
DR InterPro; IPR001590; Peptidase_M12B.
DR PANTHER; PTHR45702; ADAM10/ADAM17 METALLOPEPTIDASE FAMILY MEMBER; 1.
DR PANTHER; PTHR45702:SF6; DISINTEGRIN AND METALLOPROTEINASE DOMAIN-CONTAINING PROTEIN 17; 1.
DR Pfam; PF16698; ADAM17_MPD; 1.
DR Pfam; PF00200; Disintegrin; 1.
DR Pfam; PF13574; Reprolysin_2; 1.
DR SMART; SM00050; DISIN; 1.
DR SUPFAM; SSF57552; Blood coagulation inhibitor (disintegrin); 1.
DR SUPFAM; SSF55486; Metalloproteases ('zincins'), catalytic domain; 1.
DR PROSITE; PS50215; ADAM_MEPRO; 1.
DR PROSITE; PS50214; DISINTEGRIN_2; 1.
PE 4: Predicted;
KW Membrane {ECO:0000256|SAM:Phobius};
KW Metal-binding {ECO:0000256|PROSITE-ProRule:PRU00276};
KW Reference proteome {ECO:0000313|Proteomes:UP000276776};
KW Signal {ECO:0000256|ARBA:ARBA00022729};
KW Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}; Zinc {ECO:0000256|PROSITE-ProRule:PRU00276}.
FT TRANSMEM 654..673
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 208..451
FT /note="Peptidase M12B"
FT /evidence="ECO:0000259|PROSITE:PS50215"
FT DOMAIN 452..547
FT /note="Disintegrin"
FT /evidence="ECO:0000259|PROSITE:PS50214"
FT ACT_SITE 384
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00276"
FT BINDING 383
FT /ligand="Zn(2+)"
FT /ligand_id="ChEBI:CHEBI:29105"
FT /ligand_note="catalytic"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00276"
FT BINDING 387
FT /ligand="Zn(2+)"
FT /ligand_id="ChEBI:CHEBI:29105"
FT /ligand_note="catalytic"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00276"
FT BINDING 393
FT /ligand="Zn(2+)"
FT /ligand_id="ChEBI:CHEBI:29105"
FT /ligand_note="catalytic"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00276"
SQ SEQUENCE 707 AA; 79012 MW; 72D4577638192098 CRC64;
MEVALKTSLS RDDTDLSNRL KYYEIIKINR RLEKRGIVDI NVPYNKQERL IFRAFNRLFD
IYLTPKKGLL HRNFKCREVD GYGFEKLCTV NPDDHFGGHI HGATDSIVSL TYDDEGSLLG
IIWVAGDLYI FEPARIHFVI FFQYVMLNKN AQPWEVLAYR NSDLKMKYIT SSNGSFCSAI
SLGNQNNVSN LKSTRSKRQI LLPPVLKNRC ALRVVADYQF FKTIGNGSQA FSARYLINVI
DRVNALYTTT DWGIDEDGRR LINMGFMIKE MIIHTSPTVD QPNHYNSVSN VKRSVKAVLD
NFSRIQGSDK YCLVHLFTAQ SFENGVLGLA YISSPELNAA GGICSVQNRD RLGVVYYNTA
LSSTKATHGG TVVSREADIV TAHELGHNWG ATHDDMSLEC SPPYGSGGSY IMNTFSVSGY
DENNNHFSPC SRRLIGKVLS RKADICFEPE MSAFCGNGRV EVSTDGFAEE CDVGGLISET
VDKCCTSDCR LKPNAICSPK NSPCCSSDCQ FLPSTHLCLH ENRFQCKLSS YCTGNSGECP
EPGFVEDGTS CIEDGECLNG QCLTFCERPS VNKKPCMCSR EAVACLRCCR SENGTCEPYS
RDPKYVLKDG TRCIHGTCSR AVCIKEVADV VSHFWNIIEN LDETNFWKFV SDNLVGIIVA
VVLIVWVPAS VLIHKMDKVY EAAAKEESDN RIEVVGEKSI YKYILNS
//
