ID   A0A0N5DC37_THECL        Unreviewed;       817 AA.
AC   A0A0N5DC37;
DT   09-DEC-2015, integrated into UniProtKB/TrEMBL.
DT   09-DEC-2015, sequence version 1.
DT   27-MAR-2024, entry version 37.
DE   SubName: Full=Thyroglobulin type-1 domain-containing protein {ECO:0000313|WBParaSite:TCLT_0001075601-mRNA-1};
GN   ORFNames=TCLT_LOCUS10738 {ECO:0000313|EMBL:VDN08453.1};
OS   Thelazia callipaeda (Oriental eyeworm) (Parasitic nematode).
OC   Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC   Spirurina; Spiruromorpha; Thelazioidea; Thelaziidae; Thelazia.
OX   NCBI_TaxID=103827 {ECO:0000313|Proteomes:UP000046394, ECO:0000313|WBParaSite:TCLT_0001075601-mRNA-1};
RN   [1] {ECO:0000313|WBParaSite:TCLT_0001075601-mRNA-1}
RP   IDENTIFICATION.
RG   WormBaseParasite;
RL   Submitted (FEB-2017) to UniProtKB.
RN   [2] {ECO:0000313|EMBL:VDN08453.1, ECO:0000313|Proteomes:UP000276776}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RG   Pathogen Informatics;
RL   Submitted (NOV-2018) to the EMBL/GenBank/DDBJ databases.
CC   -!- SUBCELLULAR LOCATION: Secreted {ECO:0000256|ARBA:ARBA00004613}.
CC   -!- CAUTION: Lacks conserved residue(s) required for the propagation of
CC       feature annotation. {ECO:0000256|PROSITE-ProRule:PRU00500}.
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DR   EMBL; UYYF01005318; VDN08453.1; -; Genomic_DNA.
DR   STRING; 103827.A0A0N5DC37; -.
DR   WBParaSite; TCLT_0001075601-mRNA-1; TCLT_0001075601-mRNA-1; TCLT_0001075601.
DR   OMA; EYCGQPS; -.
DR   Proteomes; UP000046394; Unplaced.
DR   Proteomes; UP000276776; Unassembled WGS sequence.
DR   GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR   GO; GO:0004867; F:serine-type endopeptidase inhibitor activity; IEA:UniProtKB-KW.
DR   CDD; cd19941; TIL; 5.
DR   CDD; cd00191; TY; 1.
DR   Gene3D; 4.10.75.10; Elafin-like; 1.
DR   Gene3D; 2.10.25.10; Laminin; 5.
DR   InterPro; IPR036645; Elafin-like_sf.
DR   InterPro; IPR036084; Ser_inhib-like_sf.
DR   InterPro; IPR000716; Thyroglobulin_1.
DR   InterPro; IPR036857; Thyroglobulin_1_sf.
DR   InterPro; IPR002919; TIL_dom.
DR   InterPro; IPR008197; WAP_dom.
DR   PANTHER; PTHR23259:SF59; PROTEIN CBG19171; 1.
DR   PANTHER; PTHR23259; RIDDLE; 1.
DR   Pfam; PF01826; TIL; 4.
DR   Pfam; PF00095; WAP; 1.
DR   SMART; SM00211; TY; 1.
DR   SUPFAM; SSF57256; Elafin-like; 1.
DR   SUPFAM; SSF57567; Serine protease inhibitors; 3.
DR   SUPFAM; SSF57610; Thyroglobulin type-1 domain; 1.
DR   PROSITE; PS51162; THYROGLOBULIN_1_2; 1.
DR   PROSITE; PS51390; WAP; 1.
PE   4: Predicted;
KW   Coiled coil {ECO:0000256|SAM:Coils};
KW   Disulfide bond {ECO:0000256|ARBA:ARBA00023157, ECO:0000256|PROSITE-
KW   ProRule:PRU00500}; Protease inhibitor {ECO:0000256|ARBA:ARBA00022690};
KW   Reference proteome {ECO:0000313|Proteomes:UP000276776};
KW   Secreted {ECO:0000256|ARBA:ARBA00022525};
KW   Serine protease inhibitor {ECO:0000256|ARBA:ARBA00022900}.
FT   DOMAIN          102..172
FT                   /note="Thyroglobulin type-1"
FT                   /evidence="ECO:0000259|PROSITE:PS51162"
FT   DOMAIN          242..292
FT                   /note="WAP"
FT                   /evidence="ECO:0000259|PROSITE:PS51390"
FT   COILED          165..192
FT                   /evidence="ECO:0000256|SAM:Coils"
FT   DISULFID        141..148
FT                   /evidence="ECO:0000256|PROSITE-ProRule:PRU00500"
SQ   SEQUENCE   817 AA;  90793 MW;  F7916D35759D491A CRC64;
     MHKTCVDCGG ERFSYYKCNS LNDCLPNEIC TKGGFCCPLT VIPMTTSSTS NLNFEFVGFP
     TLKQESEKYS TTCPDGSSWL RECVIDSDCK SGEEVCAEGK CCAACSYRRR RVLNDLPTND
     ILGVHIPQCD QSGRYYRPTQ CRIATEECWC VSEFGKVIGS LKPKTVNLKE ACEALRLAVK
     QAEEERQKLY RKIWEGTDLR RKQENFTSVR ESNEALVKES KNLHTKSLQL EKVLIELAQK
     CLWAKRGQCP NKPELAQQVE VSSIFCHCDS DCSENRKCCP DSTGQRLICS PITNTNFTST
     KVICAENEEY VNCLDACQPT CTFRSPTPCP LEECNGGCHC KPGFIREGNE LHTPCIPRTH
     CPQQVIQSEL KNCTDPLREY TRCGPACPIS CSSLTEKCVA EGCVQGCFCK IPYILENGAD
     PIHSRCILPA YCPLTLKAYA SKINDTQQFT TISPSPKSRK IQFHIFPTNE TITMQCTDPL
     KNFQSCGSGC PVGCNNRIAG FCGTQCVAGC FCRKPYILQD AYNMNSRCIL PHQCQSFIFQ
     QQVCSDPRKQ WTHCFSNKCV RSCSNLETIC TPHNDCSPGC LCREPYVLSD ASDLNSRCVL
     PSECGSQCND SLKEYHACAS SCPMGLVFED AVNWRTSKCI TLNQCPVVNS SVTAVAFTQK
     TIITTDTVEC PTTTIDLSGK VCSVDSDCPI QQRCCHSTLF AFVSSKQSRC TCTDPHAYWD
     PCGSLCPEYC GQPAVPVCST TCNPSCRCAP EKYRDDVSKY RRTTKAYNQY NNLKDIATVK
     MLLSGEGEIA GDIKIKEINS DMIKLEGMIG GMNCIAY
//