ID A0A0N7IFF8_9BACE Unreviewed; 646 AA.
AC A0A0N7IFF8;
DT 20-JAN-2016, integrated into UniProtKB/TrEMBL.
DT 20-JAN-2016, sequence version 1.
DT 24-JAN-2024, entry version 39.
DE SubName: Full=Glycoside hydrolase family 97 protein {ECO:0000313|EMBL:KAA5415280.1};
DE SubName: Full=Retaining alpha-galactosidase {ECO:0000313|EMBL:ALJ60083.1};
DE EC=3.2.1.22 {ECO:0000313|EMBL:ALJ60083.1};
GN ORFNames=BcellWH2_02844 {ECO:0000313|EMBL:ALJ60083.1}, F2Y81_18465
GN {ECO:0000313|EMBL:KAA5415280.1};
OS Bacteroides cellulosilyticus.
OC Bacteria; Bacteroidota; Bacteroidia; Bacteroidales; Bacteroidaceae;
OC Bacteroides.
OX NCBI_TaxID=246787 {ECO:0000313|EMBL:ALJ60083.1, ECO:0000313|Proteomes:UP000061809};
RN [1] {ECO:0000313|EMBL:ALJ60083.1, ECO:0000313|Proteomes:UP000061809}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=WH2 {ECO:0000313|EMBL:ALJ60083.1,
RC ECO:0000313|Proteomes:UP000061809};
RX PubMed=26430127;
RA Wu M., McNulty N.P., Rodionov D.A., Khoroshkin M.S., Griffin N.W.,
RA Cheng J., Latreille P., Kerstetter R.A., Terrapon N., Henrissat B.,
RA Osterman A.L., Gordon J.I.;
RT "Genetic determinants of in vivo fitness and diet responsiveness in
RT multiple human gut Bacteroides.";
RL Science 350:AAC5992-AAC5992(2015).
RN [2] {ECO:0000313|EMBL:KAA5415280.1, ECO:0000313|Proteomes:UP000448877}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=BIOML-A6 {ECO:0000313|EMBL:KAA5415280.1,
RC ECO:0000313|Proteomes:UP000448877};
RX PubMed=31477907; DOI=.1038/s41591-019-0559-3;
RA Poyet M., Groussin M., Gibbons S.M., Avila-Pacheco J., Jiang X.,
RA Kearney S.M., Perrotta A.R., Berdy B., Zhao S., Lieberman T.D.,
RA Swanson P.K., Smith M., Roesemann S., Alexander J.E., Rich S.A., Livny J.,
RA Vlamakis H., Clish C., Bullock K., Deik A., Scott J., Pierce K.A.,
RA Xavier R.J., Alm E.J.;
RT "A library of human gut bacterial isolates paired with longitudinal
RT multiomics data enables mechanistic microbiome research.";
RL Nat. Med. 25:1442-1452(2019).
CC -!- COFACTOR:
CC Name=Ca(2+); Xref=ChEBI:CHEBI:29108;
CC Evidence={ECO:0000256|ARBA:ARBA00001913};
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DR EMBL; CP012801; ALJ60083.1; -; Genomic_DNA.
DR EMBL; VVYV01000034; KAA5415280.1; -; Genomic_DNA.
DR RefSeq; WP_007216476.1; NZ_VVYV01000034.1.
DR AlphaFoldDB; A0A0N7IFF8; -.
DR STRING; 246787.BcellWH2_02844; -.
DR GeneID; 66305824; -.
DR KEGG; bcel:BcellWH2_02844; -.
DR PATRIC; fig|246787.4.peg.2940; -.
DR eggNOG; COG3589; Bacteria.
DR Proteomes; UP000061809; Chromosome.
DR Proteomes; UP000448877; Unassembled WGS sequence.
DR GO; GO:0004557; F:alpha-galactosidase activity; IEA:UniProtKB-EC.
DR GO; GO:0030246; F:carbohydrate binding; IEA:InterPro.
DR GO; GO:0008152; P:metabolic process; IEA:UniProtKB-KW.
DR Gene3D; 2.70.98.10; -; 1.
DR Gene3D; 3.20.20.70; Aldolase class I; 1.
DR InterPro; IPR013785; Aldolase_TIM.
DR InterPro; IPR014718; GH-type_carb-bd.
DR InterPro; IPR029483; GH97_C.
DR InterPro; IPR019563; GH97_catalytic.
DR InterPro; IPR029486; GH97_N.
DR InterPro; IPR017853; Glycoside_hydrolase_SF.
DR PANTHER; PTHR35803; GLUCAN 1,4-ALPHA-GLUCOSIDASE SUSB-RELATED; 1.
DR PANTHER; PTHR35803:SF2; RETAINING ALPHA-GALACTOSIDASE; 1.
DR Pfam; PF14509; GH97_C; 1.
DR Pfam; PF14508; GH97_N; 1.
DR Pfam; PF10566; Glyco_hydro_97; 1.
DR SUPFAM; SSF51445; (Trans)glycosidases; 1.
PE 4: Predicted;
KW Calcium {ECO:0000256|ARBA:ARBA00022837};
KW Glycosidase {ECO:0000313|EMBL:ALJ60083.1};
KW Hydrolase {ECO:0000313|EMBL:ALJ60083.1}.
FT DOMAIN 23..286
FT /note="Glycosyl-hydrolase 97 N-terminal"
FT /evidence="ECO:0000259|Pfam:PF14508"
FT DOMAIN 299..554
FT /note="Glycosyl-hydrolase 97 catalytic"
FT /evidence="ECO:0000259|Pfam:PF10566"
FT DOMAIN 556..644
FT /note="Glycosyl-hydrolase 97 C-terminal oligomerisation"
FT /evidence="ECO:0000259|Pfam:PF14509"
SQ SEQUENCE 646 AA; 72327 MW; 1CCE05BE6CB390CE CRC64;
MKYFLVITAL LICFTIKAEE KQIASPDGKI VVTISDKNGQ PSYRISYKDT PFINSSSLGL
ITNIGDFSRE MSLEHDVQSN RIDETYTLPN IKQSNVHYVA TEGIYRFSQQ GKMIYDVIFR
VSDRDVAFKY KMYPQKNTLS CIVKEEATSF VLPDGSTTFL CPQSKPMGGF ARTSPSYETP
YKADDTMGKN GWGEGYTFPC LFRNSDKGWI LISETGVDSK YCGSRLLGHE NGLYTIGFPQ
EGEMNGNGTT APGLALPGET PWRTITLGET LAPIVETTVS FDVVKPLYEA SGKYEYGRGS
WSWIIGMDGS TKYEEQLRYI DFSAAMGYQS VLVDALWDTQ IGYDKVEKLA KYGAEKGVGL
YLWYNSNGYW NDAPQSPRGI MDNAIARRKE MKWMQSIGIR GIKVDFFGGD KQVTMQLYED
ILADANEYGL LVIFHGCTLP RGWERMYPNF ASSEAVLASE NLHFSQGSCD NEAFNACLHP
FIRNTVGSMD FGGSALNKYY NADNAPRGSR RMTSDVFALA TAVLFQSPVQ HFALAPNNLT
DAPEWAIGFM KEVPTTWDEV RFIDGYPGKY VVMARRHGDK WYVAGVNAQK ETVKLKIALP
MFMPGDQVRV FTDNEELQGN VKQIKVNKKQ ELQLAIPCNG GILIVE
//