ID A0A0N7KVW0_9PHYC Unreviewed; 868 AA.
AC A0A0N7KVW0;
DT 20-JAN-2016, integrated into UniProtKB/TrEMBL.
DT 20-JAN-2016, sequence version 1.
DT 24-JAN-2024, entry version 32.
DE RecName: Full=DNA polymerase {ECO:0000256|RuleBase:RU000442};
DE EC=2.7.7.7 {ECO:0000256|RuleBase:RU000442};
OS Yellowstone lake phycodnavirus 2.
OC Viruses; Varidnaviria; Bamfordvirae; Nucleocytoviricota; Megaviricetes;
OC Algavirales; Phycodnaviridae; Prasinovirus.
OX NCBI_TaxID=1586714 {ECO:0000313|EMBL:BAT22417.1};
RN [1] {ECO:0000313|EMBL:BAT22417.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=2 {ECO:0000313|EMBL:BAT22417.1};
RA Jaenicke S.;
RL Submitted (DEC-2014) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|EMBL:BAT22417.1}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=2 {ECO:0000313|EMBL:BAT22417.1};
RX PubMed=26459929; DOI=10.1038/srep15131;
RA Zhang W., Zhou J., Liu T., Yu Y., Pan Y., Yan S., Wang Y.;
RT "Four novel algal virus genomes discovered from Yellowstone Lake
RT metagenomes.";
RL Sci. Rep. 5:15131-15131(2015).
CC -!- CATALYTIC ACTIVITY:
CC Reaction=a 2'-deoxyribonucleoside 5'-triphosphate + DNA(n) =
CC diphosphate + DNA(n+1); Xref=Rhea:RHEA:22508, Rhea:RHEA-COMP:17339,
CC Rhea:RHEA-COMP:17340, ChEBI:CHEBI:33019, ChEBI:CHEBI:61560,
CC ChEBI:CHEBI:173112; EC=2.7.7.7;
CC Evidence={ECO:0000256|ARBA:ARBA00024632,
CC ECO:0000256|RuleBase:RU000442};
CC -!- SIMILARITY: Belongs to the DNA polymerase type-B family.
CC {ECO:0000256|ARBA:ARBA00005755, ECO:0000256|RuleBase:RU000442}.
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DR EMBL; LC015648; BAT22417.1; -; Genomic_DNA.
DR RefSeq; YP_009174598.1; NC_028110.1.
DR GeneID; 26101123; -.
DR KEGG; vg:26101123; -.
DR OrthoDB; 165at10239; -.
DR Proteomes; UP000202573; Genome.
DR GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR GO; GO:0003887; F:DNA-directed DNA polymerase activity; IEA:UniProtKB-KW.
DR GO; GO:0000166; F:nucleotide binding; IEA:InterPro.
DR GO; GO:0006260; P:DNA replication; IEA:UniProtKB-KW.
DR GO; GO:0039693; P:viral DNA genome replication; IEA:UniProtKB-KW.
DR Gene3D; 1.10.132.60; DNA polymerase family B, C-terminal domain; 1.
DR Gene3D; 3.30.342.10; DNA Polymerase, chain B, domain 1; 1.
DR Gene3D; 1.10.287.690; Helix hairpin bin; 1.
DR Gene3D; 3.90.1600.10; Palm domain of DNA polymerase; 1.
DR Gene3D; 3.30.420.10; Ribonuclease H-like superfamily/Ribonuclease H; 1.
DR InterPro; IPR006172; DNA-dir_DNA_pol_B.
DR InterPro; IPR017964; DNA-dir_DNA_pol_B_CS.
DR InterPro; IPR006133; DNA-dir_DNA_pol_B_exonuc.
DR InterPro; IPR006134; DNA-dir_DNA_pol_B_multi_dom.
DR InterPro; IPR043502; DNA/RNA_pol_sf.
DR InterPro; IPR042087; DNA_pol_B_thumb.
DR InterPro; IPR023211; DNA_pol_palm_dom_sf.
DR InterPro; IPR012337; RNaseH-like_sf.
DR InterPro; IPR036397; RNaseH_sf.
DR NCBIfam; TIGR00592; pol2; 1.
DR PANTHER; PTHR10322; DNA POLYMERASE CATALYTIC SUBUNIT; 1.
DR PANTHER; PTHR10322:SF23; DNA POLYMERASE DELTA CATALYTIC SUBUNIT; 1.
DR Pfam; PF00136; DNA_pol_B; 1.
DR Pfam; PF03104; DNA_pol_B_exo1; 1.
DR PRINTS; PR00106; DNAPOLB.
DR SMART; SM00486; POLBc; 1.
DR SUPFAM; SSF56672; DNA/RNA polymerases; 1.
DR SUPFAM; SSF53098; Ribonuclease H-like; 1.
DR PROSITE; PS00116; DNA_POLYMERASE_B; 1.
PE 3: Inferred from homology;
KW DNA replication {ECO:0000256|RuleBase:RU000442};
KW DNA-binding {ECO:0000256|ARBA:ARBA00023125, ECO:0000256|RuleBase:RU000442};
KW DNA-directed DNA polymerase {ECO:0000256|ARBA:ARBA00022932,
KW ECO:0000256|RuleBase:RU000442};
KW Nucleotidyltransferase {ECO:0000256|ARBA:ARBA00022695,
KW ECO:0000256|RuleBase:RU000442};
KW Reference proteome {ECO:0000313|Proteomes:UP000202573};
KW Transferase {ECO:0000256|ARBA:ARBA00022679, ECO:0000256|RuleBase:RU000442};
KW Viral DNA replication {ECO:0000256|ARBA:ARBA00023109}.
FT DOMAIN 61..349
FT /note="DNA-directed DNA polymerase family B exonuclease"
FT /evidence="ECO:0000259|Pfam:PF03104"
FT DOMAIN 414..843
FT /note="DNA-directed DNA polymerase family B
FT multifunctional"
FT /evidence="ECO:0000259|Pfam:PF00136"
SQ SEQUENCE 868 AA; 99468 MW; 443418C49D9749B5 CRC64;
MQSQAVAWEG DDVDDRYIVR IYGRCEDGRS ICVSTPFEPY FFIKIRPSHK FAVLKNALSR
HFYDLTEIQE ILAKDLWGFR NGLRERFVKL TFKTIKSMRI CAAMIDRMKE RDDRWEDLKA
FGQLKIYESN MDPVLRFMHV SGVRSTGWFE VAGGTPDYST SCNVNLWVED YKNITPVDRD
DVAPLRVMSF DIECYSSTGE FPNPNTTRDV VFQIGMTTRT FGSDEPMVRK CLCLKQTDAA
DCESFETERA LLERFEKYLT EVDPDIMTGW NIFGFDLEYL QVRSVLCGLA PTWGRFKDSP
IELVTKNLSS SALGNNLLKL VPMRGRYVFD FFQDVKREHK LESYSLNNVS KHFLKDQKND
MPVKEIFSRF AEGDPKRLGE VAEYCIQDTV LPHKLLDKLC QLQNQIEMAK ACWVPLSFLS
ERGQQIKVFS QMAYKARQLG FIIPVFKKPL VSGPDDGYQG ATVLDAQTGA YYGPITALDF
ASLYPSIMCA HNLCYSSMVM DPQFDNLEGV EYEQFGQFRF AQNVPSLLPV ILTDLKAFRK
KAKKLMAAAE GTPMEAVYNG QQLAYKISMN SIYGFTGASK GMLPLVAIAS TVTMRGRQMI
EETKNYVEAN FPGAHVRYGD TDSVMVEFDV QGRKGQEAID YSWQQGEQAA EQCTKLFKAP
NDLELEKVYC PYFLYSKKRY AAKMYEKGRD GAVVFKKIDV KGLQVVRRDS CPYVRETLKK
LLEMILESDD PRPPVEFAKQ AAKALTNGEV PTDKLLMSKQ LAANYKVRMP HVEVRDKIRK
RAPGSEPQQG DRVAFVIVEG PKNAKMFEKA EDPEWVLEKK IKIDYQYYFT NQLKKPVCDL
LEPLLGRDTE KLIFQPKVRT ITQFFTPK
//
