ID A0A0N7LVY2_THAGE Unreviewed; 715 AA.
AC A0A0N7LVY2;
DT 20-JAN-2016, integrated into UniProtKB/TrEMBL.
DT 20-JAN-2016, sequence version 1.
DT 27-MAR-2024, entry version 34.
DE SubName: Full=Fatty acid oxidation complex subunit alpha {ECO:0000313|EMBL:CUH67570.1};
GN Name=fadJ_3 {ECO:0000313|EMBL:CUH67570.1};
GN ORFNames=TG4357_03085 {ECO:0000313|EMBL:CUH67570.1};
OS Thalassovita gelatinovora (Thalassobius gelatinovorus).
OC Bacteria; Pseudomonadota; Alphaproteobacteria; Rhodobacterales;
OC Roseobacteraceae; Thalassovita.
OX NCBI_TaxID=53501 {ECO:0000313|EMBL:CUH67570.1, ECO:0000313|Proteomes:UP000051587};
RN [1] {ECO:0000313|EMBL:CUH67570.1, ECO:0000313|Proteomes:UP000051587}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=CECT 4357 {ECO:0000313|EMBL:CUH67570.1,
RC ECO:0000313|Proteomes:UP000051587};
RG Swine Surveillance;
RL Submitted (SEP-2015) to the EMBL/GenBank/DDBJ databases.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=a (3S)-3-hydroxyacyl-CoA + NAD(+) = a 3-oxoacyl-CoA + H(+) +
CC NADH; Xref=Rhea:RHEA:22432, ChEBI:CHEBI:15378, ChEBI:CHEBI:57318,
CC ChEBI:CHEBI:57540, ChEBI:CHEBI:57945, ChEBI:CHEBI:90726; EC=1.1.1.35;
CC Evidence={ECO:0000256|ARBA:ARBA00023693};
CC -!- PATHWAY: Lipid metabolism; fatty acid beta-oxidation.
CC {ECO:0000256|ARBA:ARBA00005005}.
CC -!- SIMILARITY: In the central section; belongs to the 3-hydroxyacyl-CoA
CC dehydrogenase family. {ECO:0000256|ARBA:ARBA00007005}.
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DR EMBL; CYSA01000026; CUH67570.1; -; Genomic_DNA.
DR RefSeq; WP_058263772.1; NZ_FOFW01000001.1.
DR AlphaFoldDB; A0A0N7LVY2; -.
DR STRING; 53501.SAMN04488043_101175; -.
DR OrthoDB; 9771883at2; -.
DR UniPathway; UPA00659; -.
DR Proteomes; UP000051587; Unassembled WGS sequence.
DR GO; GO:0003857; F:3-hydroxyacyl-CoA dehydrogenase activity; IEA:UniProtKB-EC.
DR GO; GO:0016829; F:lyase activity; IEA:UniProtKB-KW.
DR GO; GO:0070403; F:NAD+ binding; IEA:InterPro.
DR GO; GO:0006635; P:fatty acid beta-oxidation; IEA:UniProtKB-UniPathway.
DR CDD; cd06558; crotonase-like; 1.
DR Gene3D; 1.10.1040.50; -; 1.
DR Gene3D; 3.40.50.720; NAD(P)-binding Rossmann-like Domain; 1.
DR InterPro; IPR006176; 3-OHacyl-CoA_DH_NAD-bd.
DR InterPro; IPR006108; 3HC_DH_C.
DR InterPro; IPR008927; 6-PGluconate_DH-like_C_sf.
DR InterPro; IPR029045; ClpP/crotonase-like_dom_sf.
DR InterPro; IPR001753; Enoyl-CoA_hydra/iso.
DR InterPro; IPR036291; NAD(P)-bd_dom_sf.
DR PANTHER; PTHR43612; TRIFUNCTIONAL ENZYME SUBUNIT ALPHA; 1.
DR PANTHER; PTHR43612:SF3; TRIFUNCTIONAL ENZYME SUBUNIT ALPHA, MITOCHONDRIAL; 1.
DR Pfam; PF00725; 3HCDH; 1.
DR Pfam; PF02737; 3HCDH_N; 1.
DR Pfam; PF00378; ECH_1; 1.
DR SUPFAM; SSF48179; 6-phosphogluconate dehydrogenase C-terminal domain-like; 2.
DR SUPFAM; SSF52096; ClpP/crotonase; 1.
DR SUPFAM; SSF51735; NAD(P)-binding Rossmann-fold domains; 1.
PE 3: Inferred from homology;
KW Fatty acid metabolism {ECO:0000256|ARBA:ARBA00022832};
KW Lipid degradation {ECO:0000256|ARBA:ARBA00022963};
KW Lipid metabolism {ECO:0000256|ARBA:ARBA00022832};
KW Lyase {ECO:0000256|ARBA:ARBA00023239};
KW Multifunctional enzyme {ECO:0000256|ARBA:ARBA00023268};
KW NAD {ECO:0000256|ARBA:ARBA00023027};
KW Reference proteome {ECO:0000313|Proteomes:UP000051587}.
FT DOMAIN 316..493
FT /note="3-hydroxyacyl-CoA dehydrogenase NAD binding"
FT /evidence="ECO:0000259|Pfam:PF02737"
FT DOMAIN 496..599
FT /note="3-hydroxyacyl-CoA dehydrogenase C-terminal"
FT /evidence="ECO:0000259|Pfam:PF00725"
SQ SEQUENCE 715 AA; 76577 MW; E655C0A866AF5B5E CRC64;
MTDFIYEKDA DGIVIVTIDM QGQSANTMNE GYVPGMDEVL AKLRAEPDLT GVVFASAKKT
FFAGGDLRLI LAIEKSDAET LHYIEENKRP FRELEKLPVP VVAAINGAAL GGGYELCLAC
NHRIIADVKG AVVGLPEVTL GLLPGAGGVV RLTKLLGLEQ ALPHLTEGKP VKPQAALKIG
MVDAVVDSVD ALVPAAKAWI KANPDAHAQP WDQKGFRYPG GDALHPKVRQ LIMAAPAVLY
QKTRGLLPAP AKILDIAVNS MRMDYDAALL VESRGICALA VTPECKASIT TFFFGMQAIK
GGKVRPEGDH WRAKSAAILG AGMMGSGIAW AHANAGLPSV LKDMEMDKAE KGKSNTATLA
DKRIKRGRMD AAKKDQLLSM IVPATEDSAF EGTDLIVEAV FEDIALKEKV IPASFAMLGE
DGIYGSNTST LPISILAEAC PDPSRFIGLH FFSPVDKMKV VEIILGEKTS EDTLRKAYDY
VQQIGYMPIV VNDSRGFFTS RVFGTYLDEG ISLMVDGMNP VAVERAGWMA GMPVGPLAVH
DEVSLVLSQK VANTHKALDD RLGVDSGFGK HNTASKAVCD AMIAQDRGGR HYGGGFYDYA
ADGSKSLWSG LDQFAQGNAK IDIQDAIDRL LYRQAIETLR CLNEGVLRTE VEANLGGIFA
IGFPAHTGGA IQFIRGIGID RFAARAAELA DAYGERFALA ASDFDILREK VVVAA
//
