ID A0A0N8D5Z3_9CRUS Unreviewed; 490 AA.
AC A0A0N8D5Z3;
DT 20-JAN-2016, integrated into UniProtKB/TrEMBL.
DT 20-JAN-2016, sequence version 1.
DT 27-MAR-2024, entry version 26.
DE SubName: Full=25-hydroxyvitamin D-1 alpha hydroxylase, mitochondrial {ECO:0000313|EMBL:JAM38212.1};
DE SubName: Full=Cytochrome P450 49a1 {ECO:0000313|EMBL:KZS08529.1};
GN ORFNames=APZ42_027205 {ECO:0000313|EMBL:KZS08529.1};
OS Daphnia magna.
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Crustacea; Branchiopoda;
OC Diplostraca; Cladocera; Anomopoda; Daphniidae; Daphnia.
OX NCBI_TaxID=35525 {ECO:0000313|EMBL:JAM38212.1};
RN [1] {ECO:0000313|EMBL:JAM38212.1}
RP NUCLEOTIDE SEQUENCE.
RA Gilbert D., Podicheti R., Orsini L., Colbourne J., Pfrender M.;
RT "Daphnia magna gene sets from two clonal populations assembled and
RT annotated with EvidentialGene.";
RL Submitted (OCT-2015) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|EMBL:JAM38212.1}
RP NUCLEOTIDE SEQUENCE.
RA Gilbert D.G.;
RL Submitted (OCT-2015) to the EMBL/GenBank/DDBJ databases.
RN [3] {ECO:0000313|EMBL:KZS08529.1, ECO:0000313|Proteomes:UP000076858}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Xinb3 {ECO:0000313|EMBL:KZS08529.1,
RC ECO:0000313|Proteomes:UP000076858};
RC TISSUE=Complete organism {ECO:0000313|EMBL:KZS08529.1};
RA Gilbert D.G., Choi J.-H., Mockaitis K., Colbourne J., Pfrender M.;
RT "EvidentialGene: Evidence-directed Construction of Genes on Genomes.";
RL Submitted (MAR-2016) to the EMBL/GenBank/DDBJ databases.
CC -!- COFACTOR:
CC Name=heme; Xref=ChEBI:CHEBI:30413;
CC Evidence={ECO:0000256|ARBA:ARBA00001971};
CC -!- SIMILARITY: Belongs to the cytochrome P450 family.
CC {ECO:0000256|ARBA:ARBA00010617, ECO:0000256|RuleBase:RU000461}.
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DR EMBL; GDIP01065503; JAM38212.1; -; Transcribed_RNA.
DR EMBL; LRGB01002190; KZS08529.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A0N8D5Z3; -.
DR STRING; 35525.A0A0N8D5Z3; -.
DR Proteomes; UP000076858; Unassembled WGS sequence.
DR GO; GO:0020037; F:heme binding; IEA:InterPro.
DR GO; GO:0005506; F:iron ion binding; IEA:InterPro.
DR GO; GO:0004497; F:monooxygenase activity; IEA:UniProtKB-KW.
DR GO; GO:0016705; F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen; IEA:InterPro.
DR CDD; cd11054; CYP24A1-like; 1.
DR Gene3D; 1.10.630.10; Cytochrome P450; 1.
DR InterPro; IPR001128; Cyt_P450.
DR InterPro; IPR017972; Cyt_P450_CS.
DR InterPro; IPR002401; Cyt_P450_E_grp-I.
DR InterPro; IPR036396; Cyt_P450_sf.
DR PANTHER; PTHR24279; -; 1.
DR PANTHER; PTHR24279:SF117; -; 1.
DR Pfam; PF00067; p450; 1.
DR PRINTS; PR00463; EP450I.
DR PRINTS; PR00385; P450.
DR SUPFAM; SSF48264; Cytochrome P450; 1.
DR PROSITE; PS00086; CYTOCHROME_P450; 1.
PE 3: Inferred from homology;
KW Heme {ECO:0000256|RuleBase:RU000461}; Iron {ECO:0000256|RuleBase:RU000461};
KW Metal-binding {ECO:0000256|RuleBase:RU000461};
KW Monooxygenase {ECO:0000256|ARBA:ARBA00023033,
KW ECO:0000256|RuleBase:RU000461};
KW Oxidoreductase {ECO:0000256|RuleBase:RU000461};
KW Reference proteome {ECO:0000313|Proteomes:UP000076858}.
SQ SEQUENCE 490 AA; 55877 MW; A6874AB7ECE8D3D5 CRC64;
MSKRMSATEF DNAKPFDQVP GLRVLPIIGT TWGMFPHIGD GIPISRMLEL QKLRFKQFGY
IWRDIVPGRP PIVYTARPED VEKLFKTEGK HPVRPGMDTI KAYRAQRIKD FTSAGILLSS
GDAWWQTRSK TQQTFLKPKN ATHYIPVLND IAEDFIDRIR LIRPENNEMK PDFINDMYRW
ALESVGVVGL NTRLGCLRPD LAPDSEAQKL INAANFSFDA INDLEHNFPF WKFFVTPMLQ
KLYDAQDFLT DTTIKYISQT VEALKGSSFD SYLSILEQLL VRGMEPSDVV TMVIDMLMAG
VDTSANTSAF LLYYLARNPE KQEKLRQEIL SVVGPKGSTA TASALNSLPY LKACIKESFR
LMPAANANAR ITDKDLVLSG YIIPKGTLVA ALHQLMGRLD ENFPEAEKFI PERWIKGDLQ
ESHHHPYVTL PFGCGTRMCI GRKIAELEIQ QLTIKMLQNF KVEYDHEDMS CFMRMTNMPD
KPLLFKFIDL
//
