ID A0A0N8GSS1_9CHLR Unreviewed; 263 AA.
AC A0A0N8GSS1;
DT 20-JAN-2016, integrated into UniProtKB/TrEMBL.
DT 20-JAN-2016, sequence version 1.
DT 24-JAN-2024, entry version 28.
DE RecName: Full=Uridine phosphorylase {ECO:0000256|ARBA:ARBA00021980, ECO:0000256|RuleBase:RU361131};
DE EC=2.4.2.3 {ECO:0000256|ARBA:ARBA00011888, ECO:0000256|RuleBase:RU361131};
GN ORFNames=ADN01_02715 {ECO:0000313|EMBL:KPL90082.1};
OS Levilinea saccharolytica.
OC Bacteria; Chloroflexota; Anaerolineae; Anaerolineales; Anaerolineaceae;
OC Levilinea.
OX NCBI_TaxID=229921 {ECO:0000313|EMBL:KPL90082.1, ECO:0000313|Proteomes:UP000050501};
RN [1] {ECO:0000313|EMBL:KPL90082.1, ECO:0000313|Proteomes:UP000050501}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=KIBI-1 {ECO:0000313|EMBL:KPL90082.1,
RC ECO:0000313|Proteomes:UP000050501};
RA Hemp J., Ward L.M., Pace L.A., Fischer W.W.;
RT "Genome sequence of Levilinea saccharolytica DSM 16555.";
RL Submitted (JUL-2015) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: Catalyzes the reversible phosphorylytic cleavage of uridine
CC to uracil and ribose-1-phosphate. {ECO:0000256|RuleBase:RU361131}.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=phosphate + uridine = alpha-D-ribose 1-phosphate + uracil;
CC Xref=Rhea:RHEA:24388, ChEBI:CHEBI:16704, ChEBI:CHEBI:17568,
CC ChEBI:CHEBI:43474, ChEBI:CHEBI:57720; EC=2.4.2.3;
CC Evidence={ECO:0000256|ARBA:ARBA00001020,
CC ECO:0000256|RuleBase:RU361131};
CC -!- PATHWAY: Pyrimidine metabolism; UMP biosynthesis via salvage pathway;
CC uracil from uridine (phosphorylase route): step 1/1.
CC {ECO:0000256|ARBA:ARBA00004825, ECO:0000256|RuleBase:RU361131}.
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000256|ARBA:ARBA00004496}.
CC -!- SIMILARITY: Belongs to the PNP/UDP phosphorylase family.
CC {ECO:0000256|ARBA:ARBA00010456, ECO:0000256|RuleBase:RU361131}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:KPL90082.1}.
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DR EMBL; LGCM01000013; KPL90082.1; -; Genomic_DNA.
DR RefSeq; WP_062416706.1; NZ_LGCM01000013.1.
DR AlphaFoldDB; A0A0N8GSS1; -.
DR STRING; 229921.ADN01_02715; -.
DR PATRIC; fig|229921.5.peg.2539; -.
DR OrthoDB; 7945729at2; -.
DR UniPathway; UPA00574; UER00633.
DR Proteomes; UP000050501; Unassembled WGS sequence.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR GO; GO:0004850; F:uridine phosphorylase activity; IEA:UniProtKB-EC.
DR GO; GO:0009164; P:nucleoside catabolic process; IEA:UniProt.
DR GO; GO:0009166; P:nucleotide catabolic process; IEA:InterPro.
DR GO; GO:0044206; P:UMP salvage; IEA:UniProtKB-UniPathway.
DR CDD; cd17767; UP_EcUdp-like; 1.
DR Gene3D; 3.40.50.1580; Nucleoside phosphorylase domain; 1.
DR InterPro; IPR018016; Nucleoside_phosphorylase_CS.
DR InterPro; IPR000845; Nucleoside_phosphorylase_d.
DR InterPro; IPR035994; Nucleoside_phosphorylase_sf.
DR InterPro; IPR010058; Uridine_phosphorylase.
DR NCBIfam; TIGR01718; Uridine-psphlse; 1.
DR PANTHER; PTHR43691; URIDINE PHOSPHORYLASE; 1.
DR PANTHER; PTHR43691:SF13; URIDINE PHOSPHORYLASE; 1.
DR Pfam; PF01048; PNP_UDP_1; 1.
DR SUPFAM; SSF53167; Purine and uridine phosphorylases; 1.
DR PROSITE; PS01232; PNP_UDP_1; 1.
PE 3: Inferred from homology;
KW Cytoplasm {ECO:0000256|ARBA:ARBA00022490};
KW Glycosyltransferase {ECO:0000256|ARBA:ARBA00022676,
KW ECO:0000256|RuleBase:RU361131};
KW Reference proteome {ECO:0000313|Proteomes:UP000050501};
KW Transferase {ECO:0000256|ARBA:ARBA00022679, ECO:0000256|RuleBase:RU361131}.
FT DOMAIN 20..253
FT /note="Nucleoside phosphorylase"
FT /evidence="ECO:0000259|Pfam:PF01048"
SQ SEQUENCE 263 AA; 28731 MW; A7FCCB253A7C36EF CRC64;
METPDQLQHH IHMKKGDVGR YVLLPGDPGR SEKIAQYFDN PQFVAQHREY VTYTGTLLGE
KVSVTSTGIG CPSTAIAVEE LIAIGADTFI RVGTSGGMQP GIKTGDVAVV TGAIRDEGTT
LHYLPPEFPA VADVDVVLAL EEGARRAGIR SWRGISQSKD SFYGEVEPQR MPVDKRLAER
WKAWIAGGAV CSEMEAAAIF IISSIHRKRA SGVMLMGSMA EEDQPHTPEE WKAMEALFDV
DRAIRVAIEG LKALIEQDRQ RGA
//
