ID A0A0N8H936_9HYPO Unreviewed; 1433 AA.
AC A0A0N8H936;
DT 20-JAN-2016, integrated into UniProtKB/TrEMBL.
DT 20-JAN-2016, sequence version 1.
DT 24-JAN-2024, entry version 25.
DE RecName: Full=Pre-mRNA-splicing factor {ECO:0000256|PIRNR:PIRNR038901};
GN ORFNames=AK830_g338 {ECO:0000313|EMBL:KPM46276.1};
OS Neonectria ditissima.
OC Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Sordariomycetes;
OC Hypocreomycetidae; Hypocreales; Nectriaceae; Neonectria.
OX NCBI_TaxID=78410 {ECO:0000313|EMBL:KPM46276.1, ECO:0000313|Proteomes:UP000050424};
RN [1] {ECO:0000313|EMBL:KPM46276.1, ECO:0000313|Proteomes:UP000050424}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=R09/05 {ECO:0000313|EMBL:KPM46276.1,
RC ECO:0000313|Proteomes:UP000050424};
RA Gomez-Cortecero A., Harrison R.J., Armitage A.D.;
RT "Draft genome of a European isolate of the apple canker pathogen Neonectria
RT ditissima.";
RL Submitted (SEP-2015) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: Involved in mRNA splicing where it associates with cdc5 and
CC the other cwf proteins as part of the spliceosome.
CC {ECO:0000256|PIRNR:PIRNR038901}.
CC -!- SUBUNIT: Belongs to the 40S cdc5-associated complex (or cwf complex), a
CC spliceosome sub-complex reminiscent of a late-stage spliceosome.
CC {ECO:0000256|PIRNR:PIRNR038901}.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|PIRNR:PIRNR038901}.
CC -!- SIMILARITY: Belongs to the CWF11 family.
CC {ECO:0000256|PIRNR:PIRNR038901}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:KPM46276.1}.
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DR EMBL; LKCW01000002; KPM46276.1; -; Genomic_DNA.
DR STRING; 78410.A0A0N8H936; -.
DR OrthoDB; 7041at2759; -.
DR Proteomes; UP000050424; Unassembled WGS sequence.
DR GO; GO:0005684; C:U2-type spliceosomal complex; IEA:UniProtKB-UniRule.
DR GO; GO:0004386; F:helicase activity; IEA:InterPro.
DR GO; GO:0045292; P:mRNA cis splicing, via spliceosome; IEA:UniProtKB-UniRule.
DR CDD; cd17935; EEXXQc_AQR; 1.
DR CDD; cd18808; SF1_C_Upf1; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 2.
DR InterPro; IPR048966; Aquarius_b-barrel.
DR InterPro; IPR048967; Aquarius_insert.
DR InterPro; IPR032174; Aquarius_N.
DR InterPro; IPR026300; CWF11_fam.
DR InterPro; IPR045055; DNA2/NAM7-like.
DR InterPro; IPR041679; DNA2/NAM7-like_C.
DR InterPro; IPR041677; DNA2/NAM7_AAA_11.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR047187; SF1_C_Upf1.
DR PANTHER; PTHR10887; DNA2/NAM7 HELICASE FAMILY; 1.
DR PANTHER; PTHR10887:SF5; RNA HELICASE AQUARIUS; 1.
DR Pfam; PF13086; AAA_11; 1.
DR Pfam; PF13087; AAA_12; 1.
DR Pfam; PF16399; Aquarius_N_1st; 1.
DR Pfam; PF21143; Aquarius_N_2nd; 1.
DR Pfam; PF21144; Aquarius_N_3rd; 1.
DR PIRSF; PIRSF038901; AQR_cwf11; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
PE 3: Inferred from homology;
KW mRNA processing {ECO:0000256|PIRNR:PIRNR038901};
KW mRNA splicing {ECO:0000256|PIRNR:PIRNR038901};
KW Nucleus {ECO:0000256|PIRNR:PIRNR038901};
KW Reference proteome {ECO:0000313|Proteomes:UP000050424}.
FT DOMAIN 41..429
FT /note="RNA helicase aquarius N-terminal"
FT /evidence="ECO:0000259|Pfam:PF16399"
FT DOMAIN 508..669
FT /note="RNA helicase aquarius beta-barrel"
FT /evidence="ECO:0000259|Pfam:PF21143"
FT DOMAIN 717..808
FT /note="RNA helicase aquarius insertion"
FT /evidence="ECO:0000259|Pfam:PF21144"
FT DOMAIN 821..1119
FT /note="DNA2/NAM7 helicase helicase"
FT /evidence="ECO:0000259|Pfam:PF13086"
FT DOMAIN 1128..1320
FT /note="DNA2/NAM7 helicase-like C-terminal"
FT /evidence="ECO:0000259|Pfam:PF13087"
FT REGION 1..38
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 754..782
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 13..38
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1433 AA; 162520 MW; EE706E7BABEC9E5E CRC64;
MPNVKRLKGS GAAKAQKKPE RQPKSTDGRP TPAEVEEEEH QFVQVARKHW LKPTKKPTKP
KVKNDVLKQS IWDQLEREGF QYKSLLLLES LQTLESYLWP GYTEEASNYH VLLIALIANV
KRREHLETWG LFEERPDEFS SLFRRLLSMM LDRTLSVTVR TQLLCFLIHA FQSLDCTIVR
KECAPLVSIG IWHNLSTENL RESKLDQTPH LRKAWKAAHK RYDAADDATK ARLRFERSWL
YTLLLDFLGL LYTEGSKPDQ VLYCERFSEF ISDLQSQLPT RRYVNTLLQD LHLVPAMKLA
PMYNDEENTL LRELHALLAH YSYFTIDDQT GVQHSSTEAY DKHCKLLGKL QHISLKHFRE
KLAVLALSNY GAIDKREELG PLLEPLADEE ILKLMTLLNL RTSYPESLNL PVTRKLLLEV
LLTIFERRKT FQEKARSMGL LPTEHSLFDN SFQQAESYDG SHPMALPKLN LQYLSVGDFL
WRALILYRCE SFYGVRKDIE SALRRLRPES KQPGETTFAG FSKMALSVSK PSILEVVPAL
VGDDQPSMVR AEILVDVRRL GEGVRREWDS LRQDDVVFLL HVEAPTKQVS NGGEALSESE
MLGVVSVRAA SILQITDEKG RHVRDGASNL DSKRRIQLKL DSRTFTEDAA RASAGKPDVY
AGVNLLLRRG RRENNFKPVL ESIRSLVLSE VPLPAWLHEV FLGYGDPAGA NYKNLPNRAK
KVDFRDTFLD WQHLTESMPG KIIDPGDEVS GSFGPPYVLE SVEKSEAPKR AKPSKKRRRD
ANPALISDIE TLKASTYQPP NMGPYPINTP RQNSVRFTPA QVEAITSGTQ PGLTVVVGPP
GTGKTDVATQ IISNIYHNFP EQKTLLIAHS NQALNQLFAK IVALDIDERH LLRLGHGEEE
LDTEGNFSKH GRVESFLENR DRYLHEVKRL AASLGAPGAH ENSAETAGYF NTVYVEPMWT
KFLQIAESDD STAAAIIQAF PFHTYFSDAP QPVFPEEAGR EQVLEVARGC YRHISKIFSE
LADALPFEIL RRERDKANYL LTSEARIVAM TTTHAAIRRG EIASLKFHYD NVVMEEAAQI
TEIETFMPLA MQTPVQGKMP LQRVILCGDH FQNSPVIQSL AFRHYANLEQ SLFSRLVRLG
VPTITLDKQG RARSSIARLY QWRYENLENL SAVQNNPEFV KANAGFKFDY QFVNVPDYKG
RGESEPTPHF VQNLGEAEYA VAIYQYMRLL GYPAETISIL TTYAGQRALV KDVLFHRCAR
NPVFGLPKAV ATVDKYQGEQ NDYIILSLTR TSRVGYLRDV RRMTVALSRA RLGLYILGRR
EVFEACPELR PAFDLLLQRP DKLMLVTGEL WPTERDYSEG IGPIEAEVPM EGVEHLGQYV
FEMTNTKIKQ LQGGQSGSGV PEAIVEEVEG AEETYEEDGE EVEADILEVR EGE
//
