ID A0A0N8P043_DROAN Unreviewed; 1988 AA.
AC A0A0N8P043;
DT 20-JAN-2016, integrated into UniProtKB/TrEMBL.
DT 20-JAN-2016, sequence version 1.
DT 27-MAR-2024, entry version 31.
DE SubName: Full=Uncharacterized protein, isoform C {ECO:0000313|EMBL:KPU76084.1};
GN Name=Dana\GF12843 {ECO:0000313|EMBL:KPU76084.1};
GN Synonyms=dana_GLEANR_12861 {ECO:0000313|EMBL:KPU76084.1};
GN ORFNames=GF12843 {ECO:0000313|EMBL:KPU76084.1};
OS Drosophila ananassae (Fruit fly).
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea;
OC Drosophilidae; Drosophila; Sophophora.
OX NCBI_TaxID=7217 {ECO:0000313|EMBL:KPU76084.1, ECO:0000313|Proteomes:UP000007801};
RN [1] {ECO:0000313|EMBL:KPU76084.1, ECO:0000313|Proteomes:UP000007801}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Tucson 14024-0371.13 {ECO:0000313|Proteomes:UP000007801};
RX PubMed=17994087; DOI=10.1038/nature06341;
RG Drosophila 12 genomes consortium;
RA Clark A.G., Eisen M.B., Smith D.R., Bergman C.M., Oliver B., Markow T.A.,
RA Kaufman T.C., Kellis M., Gelbart W., Iyer V.N., Pollard D.A., Sackton T.B.,
RA Larracuente A.M., Singh N.D., Abad J.P., Abt D.N., Adryan B., Aguade M.,
RA Akashi H., Anderson W.W., Aquadro C.F., Ardell D.H., Arguello R.,
RA Artieri C.G., Barbash D.A., Barker D., Barsanti P., Batterham P.,
RA Batzoglou S., Begun D., Bhutkar A., Blanco E., Bosak S.A., Bradley R.K.,
RA Brand A.D., Brent M.R., Brooks A.N., Brown R.H., Butlin R.K., Caggese C.,
RA Calvi B.R., Bernardo de Carvalho A., Caspi A., Castrezana S.,
RA Celniker S.E., Chang J.L., Chapple C., Chatterji S., Chinwalla A.,
RA Civetta A., Clifton S.W., Comeron J.M., Costello J.C., Coyne J.A., Daub J.,
RA David R.G., Delcher A.L., Delehaunty K., Do C.B., Ebling H., Edwards K.,
RA Eickbush T., Evans J.D., Filipski A., Findeiss S., Freyhult E., Fulton L.,
RA Fulton R., Garcia A.C., Gardiner A., Garfield D.A., Garvin B.E., Gibson G.,
RA Gilbert D., Gnerre S., Godfrey J., Good R., Gotea V., Gravely B.,
RA Greenberg A.J., Griffiths-Jones S., Gross S., Guigo R., Gustafson E.A.,
RA Haerty W., Hahn M.W., Halligan D.L., Halpern A.L., Halter G.M., Han M.V.,
RA Heger A., Hillier L., Hinrichs A.S., Holmes I., Hoskins R.A., Hubisz M.J.,
RA Hultmark D., Huntley M.A., Jaffe D.B., Jagadeeshan S., Jeck W.R.,
RA Johnson J., Jones C.D., Jordan W.C., Karpen G.H., Kataoka E.,
RA Keightley P.D., Kheradpour P., Kirkness E.F., Koerich L.B., Kristiansen K.,
RA Kudrna D., Kulathinal R.J., Kumar S., Kwok R., Lander E., Langley C.H.,
RA Lapoint R., Lazzaro B.P., Lee S.J., Levesque L., Li R., Lin C.F., Lin M.F.,
RA Lindblad-Toh K., Llopart A., Long M., Low L., Lozovsky E., Lu J., Luo M.,
RA Machado C.A., Makalowski W., Marzo M., Matsuda M., Matzkin L.,
RA McAllister B., McBride C.S., McKernan B., McKernan K., Mendez-Lago M.,
RA Minx P., Mollenhauer M.U., Montooth K., Mount S.M., Mu X., Myers E.,
RA Negre B., Newfeld S., Nielsen R., Noor M.A., O'Grady P., Pachter L.,
RA Papaceit M., Parisi M.J., Parisi M., Parts L., Pedersen J.S., Pesole G.,
RA Phillippy A.M., Ponting C.P., Pop M., Porcelli D., Powell J.R.,
RA Prohaska S., Pruitt K., Puig M., Quesneville H., Ram K.R., Rand D.,
RA Rasmussen M.D., Reed L.K., Reenan R., Reily A., Remington K.A.,
RA Rieger T.T., Ritchie M.G., Robin C., Rogers Y.H., Rohde C., Rozas J.,
RA Rubenfield M.J., Ruiz A., Russo S., Salzberg S.L., Sanchez-Gracia A.,
RA Saranga D.J., Sato H., Schaeffer S.W., Schatz M.C., Schlenke T.,
RA Schwartz R., Segarra C., Singh R.S., Sirot L., Sirota M., Sisneros N.B.,
RA Smith C.D., Smith T.F., Spieth J., Stage D.E., Stark A., Stephan W.,
RA Strausberg R.L., Strempel S., Sturgill D., Sutton G., Sutton G.G., Tao W.,
RA Teichmann S., Tobari Y.N., Tomimura Y., Tsolas J.M., Valente V.L.,
RA Venter E., Venter J.C., Vicario S., Vieira F.G., Vilella A.J.,
RA Villasante A., Walenz B., Wang J., Wasserman M., Watts T., Wilson D.,
RA Wilson R.K., Wing R.A., Wolfner M.F., Wong A., Wong G.K., Wu C.I., Wu G.,
RA Yamamoto D., Yang H.P., Yang S.P., Yorke J.A., Yoshida K., Zdobnov E.,
RA Zhang P., Zhang Y., Zimin A.V., Baldwin J., Abdouelleil A., Abdulkadir J.,
RA Abebe A., Abera B., Abreu J., Acer S.C., Aftuck L., Alexander A., An P.,
RA Anderson E., Anderson S., Arachi H., Azer M., Bachantsang P., Barry A.,
RA Bayul T., Berlin A., Bessette D., Bloom T., Blye J., Boguslavskiy L.,
RA Bonnet C., Boukhgalter B., Bourzgui I., Brown A., Cahill P., Channer S.,
RA Cheshatsang Y., Chuda L., Citroen M., Collymore A., Cooke P., Costello M.,
RA D'Aco K., Daza R., De Haan G., DeGray S., DeMaso C., Dhargay N., Dooley K.,
RA Dooley E., Doricent M., Dorje P., Dorjee K., Dupes A., Elong R., Falk J.,
RA Farina A., Faro S., Ferguson D., Fisher S., Foley C.D., Franke A.,
RA Friedrich D., Gadbois L., Gearin G., Gearin C.R., Giannoukos G., Goode T.,
RA Graham J., Grandbois E., Grewal S., Gyaltsen K., Hafez N., Hagos B.,
RA Hall J., Henson C., Hollinger A., Honan T., Huard M.D., Hughes L.,
RA Hurhula B., Husby M.E., Kamat A., Kanga B., Kashin S., Khazanovich D.,
RA Kisner P., Lance K., Lara M., Lee W., Lennon N., Letendre F., LeVine R.,
RA Lipovsky A., Liu X., Liu J., Liu S., Lokyitsang T., Lokyitsang Y.,
RA Lubonja R., Lui A., MacDonald P., Magnisalis V., Maru K., Matthews C.,
RA McCusker W., McDonough S., Mehta T., Meldrim J., Meneus L., Mihai O.,
RA Mihalev A., Mihova T., Mittelman R., Mlenga V., Montmayeur A., Mulrain L.,
RA Navidi A., Naylor J., Negash T., Nguyen T., Nguyen N., Nicol R., Norbu C.,
RA Norbu N., Novod N., O'Neill B., Osman S., Markiewicz E., Oyono O.L.,
RA Patti C., Phunkhang P., Pierre F., Priest M., Raghuraman S., Rege F.,
RA Reyes R., Rise C., Rogov P., Ross K., Ryan E., Settipalli S., Shea T.,
RA Sherpa N., Shi L., Shih D., Sparrow T., Spaulding J., Stalker J.,
RA Stange-Thomann N., Stavropoulos S., Stone C., Strader C., Tesfaye S.,
RA Thomson T., Thoulutsang Y., Thoulutsang D., Topham K., Topping I.,
RA Tsamla T., Vassiliev H., Vo A., Wangchuk T., Wangdi T., Weiand M.,
RA Wilkinson J., Wilson A., Yadav S., Young G., Yu Q., Zembek L., Zhong D.,
RA Zimmer A., Zwirko Z., Jaffe D.B., Alvarez P., Brockman W., Butler J.,
RA Chin C., Gnerre S., Grabherr M., Kleber M., Mauceli E., MacCallum I.;
RT "Evolution of genes and genomes on the Drosophila phylogeny.";
RL Nature 450:203-218(2007).
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DR EMBL; CH902619; KPU76084.1; -; Genomic_DNA.
DR RefSeq; XP_014763457.1; XM_014907971.1.
DR SMR; A0A0N8P043; -.
DR STRING; 7217.A0A0N8P043; -.
DR EnsemblMetazoa; FBtr0389563; FBpp0349169; FBgn0089877.
DR GeneID; 6495689; -.
DR InParanoid; A0A0N8P043; -.
DR OrthoDB; 204547at2759; -.
DR Proteomes; UP000007801; Unassembled WGS sequence.
DR GO; GO:0005801; C:cis-Golgi network; IEA:EnsemblMetazoa.
DR GO; GO:0000137; C:Golgi cis cisterna; IEA:EnsemblMetazoa.
DR GO; GO:0005085; F:guanyl-nucleotide exchange factor activity; IEA:EnsemblMetazoa.
DR GO; GO:0031267; F:small GTPase binding; IEA:EnsemblMetazoa.
DR GO; GO:0000902; P:cell morphogenesis; IEA:EnsemblMetazoa.
DR GO; GO:0002064; P:epithelial cell development; IEA:EnsemblMetazoa.
DR GO; GO:0007030; P:Golgi organization; IEA:EnsemblMetazoa.
DR GO; GO:0035149; P:lumen formation, open tracheal system; IEA:EnsemblMetazoa.
DR GO; GO:0045807; P:positive regulation of endocytosis; IEA:EnsemblMetazoa.
DR GO; GO:0009306; P:protein secretion; IEA:EnsemblMetazoa.
DR GO; GO:0032012; P:regulation of ARF protein signal transduction; IEA:InterPro.
DR GO; GO:0043087; P:regulation of GTPase activity; IEA:EnsemblMetazoa.
DR GO; GO:0035158; P:regulation of tube diameter, open tracheal system; IEA:EnsemblMetazoa.
DR GO; GO:0007431; P:salivary gland development; IEA:EnsemblMetazoa.
DR GO; GO:0016192; P:vesicle-mediated transport; IEA:UniProt.
DR CDD; cd00171; Sec7; 1.
DR Gene3D; 1.10.220.20; -; 1.
DR Gene3D; 1.10.1000.11; Arf Nucleotide-binding Site Opener,domain 2; 1.
DR InterPro; IPR032691; Mon2/Sec7/BIG1-like_HUS.
DR InterPro; IPR023394; Sec7_C_sf.
DR InterPro; IPR000904; Sec7_dom.
DR InterPro; IPR035999; Sec7_dom_sf.
DR PANTHER; PTHR10663:SF388; GOLGI-SPECIFIC BREFELDIN A-RESISTANCE GUANINE NUCLEOTIDE EXCHANGE FACTOR 1; 1.
DR PANTHER; PTHR10663; GUANYL-NUCLEOTIDE EXCHANGE FACTOR; 1.
DR Pfam; PF01369; Sec7; 1.
DR Pfam; PF12783; Sec7-like_HUS; 1.
DR SMART; SM00222; Sec7; 1.
DR SUPFAM; SSF48425; Sec7 domain; 1.
DR PROSITE; PS50190; SEC7; 1.
PE 4: Predicted;
KW Reference proteome {ECO:0000313|Proteomes:UP000007801}.
FT DOMAIN 642..834
FT /note="SEC7"
FT /evidence="ECO:0000259|PROSITE:PS50190"
FT REGION 223..263
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 292..311
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 566..590
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1263..1299
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1394..1424
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 246..262
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1277..1299
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1394..1411
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1988 AA; 221133 MW; 1AAAF96A90212EBF CRC64;
MSLPGNGIYV VRGEMATLMT AMRRGTRWNA TAYVNEEKDS LLKLFLDLKQ DLNRVEDLRL
IEAQVFLAPF LEVIRTADTT GPLTSLALAS VNKFLSYGLI DPTTPNLSDI VERIADAVTH
ARFMGTDQSS DSVTFMRVIE VLHTLIRSPE GAALSNDTMC DVMLSCFKIC FESRLSEILR
RSAEQSLKDM VLLFFMRLPQ FAEERSDAVL QKRFTILDAA SGAAQEKHKR KVPQAAVPAH
PRKSSTAEEP PQTPQPSSNL TVPGHLKAPI LATTPASPAG TILDMQGKIT QTPTTTASAG
AVSEETETTD TPAIQVEHAD SELLAEGEPG EATSLLTEAS SSEYINSVGV RFTQQSSEQD
TASLSPYGLP FIRELFRFLT ILCNPLDKQN TDSMMHTGLS LLTVAFEVAA DNIGKYEGLL
ELVKDDLCRN LISLLSSERL SIFAADLQLC FLLFESLRGH LKFQLEAYLK KLSEIIASDN
PKTPYEMREL ALDNLLQLWR IPGFVTELYI NYDCDLYCTD MFESLTNLLS KYTLSATNAV
YSTHIISMDT LISVIDSIER NCVASKGQQG GANKESPPEV TPLAGGSRHS RHNSGLEGIV
IDSGTSAAVE ERVENISSFI NSSSQRLRLQ SGGDALGITS EQLANVKQKK RLLSQGTERF
NTRPEKGIQY LQEHGILNAE LDPMQVALFL RENPGLDKKM IGEYISKKKN VDSKILINFV
DSFDFTGLRV DQALRLYLET FRLPGEAPLI FLVLEHFSDH WHLQNKEPFA NVDAAFRLAY
AIIMLNMDQH NSNAKRLNVP MTLEDFTKNL RGLNGGNDFD QEMLTQVFNA IKNEEIVMPA
EQTGLVRENY LWKVLLRRGD THDGNFHYVH DASYDVEIFN IVWGASLSAL SFMFDKSTES
GYQKTLAGFS KSAAISAHYN LHADFDALVL TLCKFTTLLS SVEQNEVAPA NNEIQQAVNF
GLNDKAQAAI RTVFLLVHDY GDCLRESWKH ILDLYLQLFR LKLLPKSLIE VEDFCEANGK
ALLILEKPRE KQESGLFSSL YSFISSEGQR EPTYEEQDYI KHGRKCIKEC QLDQMLQESK
FVQLESLQEL LKCVLGLIKA PQGHKSIGLP YAEDQTVFWM EFLVKIVVHN RDRMIPLWPA
VRDQMYLLLM GSASCGYDYL LNRCIVAVLK LAIYLMRNEE LCPIVLQSLK MLLMLKPALL
LRISKQISIG IYELLKTSAQ NIHSEQDWQI IFNLLECVGA GAVPPSYDDA QLPLPLNGCA
KSDGALSGEE DTSPAPERGY TSDSELTKTS ATPAASSPSA ENWILVNNKD SELTTASRPQ
SPPSSSGPAI STLVYNCQLL DHAPFALFKC WDSLAFIVRS VAHITPYNFE ACVRCIRIFV
EACRDGGIRQ RRKLEAAGKQ RSSKKRSDRK PGMAPSVSSS NLTLLSGDPA DNLGNGNAAE
QEELAQRYEQ LSIQLLDLMY TLYTRTAQIF RWWAEEGCTV PQSAALWAPG WCPLLQGIAR
LAMDRRREVR THAISCLQQR ALLVHDLQTL SGTEWCSCFH QVLFPLLNEL LPESSASSQL
DSALLEESRI RTATIMSKVF LQHLTTLIEL GNTFNELWLD ILDYIERFMK VGSDTLSEQM
QEILKNMLLV MHSVRVFHNQ DGSLQQALWE LTWRRIGEFL PNLKEELFRD EGKRAQTLTN
PAVVAAAASN PQQQVPTVAI LPSQVQQQQV AANELVVSAA TSGTATPSLV SPVESPRRSI
ILQPPMADAL QQAPSFIFAQ PMIVPPQPPV ATEAHSSALL PDLVNEAAAA TVQVGPSSPV
LSPQPEEQPV AIVQQTNIVT TNNTYNSYAI ELPATPEATA EQLEQQQQQQ LLYQQYYQQY
QAQQLQLQQQ QQQQQQLSAP SSDPAINVPI SHLLAGNAYP SLSKMPQSSI VHSFAPVYET
PAVASGAAPT ADIYQEYVQN PYNLTLQQNL QQNPQQQLQQ SQTPANYFNV SVDPNNIPPG
SELLYGQQ
//
