ID A0A0N9I3U3_9PSEU Unreviewed; 1020 AA.
AC A0A0N9I3U3;
DT 20-JAN-2016, integrated into UniProtKB/TrEMBL.
DT 20-JAN-2016, sequence version 1.
DT 27-MAR-2024, entry version 39.
DE RecName: Full=DNA 3'-5' helicase {ECO:0000256|ARBA:ARBA00034808};
DE EC=5.6.2.4 {ECO:0000256|ARBA:ARBA00034808};
GN ORFNames=AOZ06_47175 {ECO:0000313|EMBL:ALG13441.1};
OS Kibdelosporangium phytohabitans.
OC Bacteria; Actinomycetota; Actinomycetes; Pseudonocardiales;
OC Pseudonocardiaceae; Kibdelosporangium.
OX NCBI_TaxID=860235 {ECO:0000313|EMBL:ALG13441.1, ECO:0000313|Proteomes:UP000063699};
RN [1] {ECO:0000313|EMBL:ALG13441.1, ECO:0000313|Proteomes:UP000063699}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=KLBMP1111 {ECO:0000313|EMBL:ALG13441.1,
RC ECO:0000313|Proteomes:UP000063699};
RA Qin S., Xing K.;
RT "Genome sequencing of Kibdelosporangium phytohabitans.";
RL Submitted (JUL-2015) to the EMBL/GenBank/DDBJ databases.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=ATP + H2O = ADP + H(+) + phosphate; Xref=Rhea:RHEA:13065,
CC ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:30616,
CC ChEBI:CHEBI:43474, ChEBI:CHEBI:456216; EC=5.6.2.4;
CC Evidence={ECO:0000256|ARBA:ARBA00034618};
CC -!- CATALYTIC ACTIVITY:
CC Reaction=Couples ATP hydrolysis with the unwinding of duplex DNA by
CC translocating in the 3'-5' direction.; EC=5.6.2.4;
CC Evidence={ECO:0000256|ARBA:ARBA00034617};
CC -!- SIMILARITY: Belongs to the helicase family. UvrD subfamily.
CC {ECO:0000256|ARBA:ARBA00009922}.
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DR EMBL; CP012752; ALG13441.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A0N9I3U3; -.
DR STRING; 860235.AOZ06_47175; -.
DR KEGG; kphy:AOZ06_47175; -.
DR OrthoDB; 9806690at2; -.
DR Proteomes; UP000063699; Chromosome.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR GO; GO:0016887; F:ATP hydrolysis activity; IEA:RHEA.
DR GO; GO:0003677; F:DNA binding; IEA:InterPro.
DR GO; GO:0003678; F:DNA helicase activity; IEA:InterPro.
DR CDD; cd17932; DEXQc_UvrD; 1.
DR CDD; cd19067; PfuEndoQ-like; 1.
DR CDD; cd18807; SF1_C_UvrD; 1.
DR Gene3D; 1.10.10.160; -; 1.
DR Gene3D; 3.20.20.140; Metal-dependent hydrolases; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 3.
DR InterPro; IPR013986; DExx_box_DNA_helicase_dom_sf.
DR InterPro; IPR014017; DNA_helicase_UvrD-like_C.
DR InterPro; IPR000212; DNA_helicase_UvrD/REP.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR016195; Pol/histidinol_Pase-like.
DR InterPro; IPR014016; UvrD-like_ATP-bd.
DR PANTHER; PTHR11070:SF2; ATP-DEPENDENT DNA HELICASE SRS2; 1.
DR PANTHER; PTHR11070; UVRD / RECB / PCRA DNA HELICASE FAMILY MEMBER; 1.
DR Pfam; PF00580; UvrD-helicase; 1.
DR Pfam; PF13361; UvrD_C; 2.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR SUPFAM; SSF89550; PHP domain-like; 1.
DR PROSITE; PS51198; UVRD_HELICASE_ATP_BIND; 1.
DR PROSITE; PS51217; UVRD_HELICASE_CTER; 1.
PE 3: Inferred from homology;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840, ECO:0000256|PROSITE-
KW ProRule:PRU00560};
KW Helicase {ECO:0000256|ARBA:ARBA00022806, ECO:0000256|PROSITE-
KW ProRule:PRU00560};
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801, ECO:0000256|PROSITE-
KW ProRule:PRU00560};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741, ECO:0000256|PROSITE-
KW ProRule:PRU00560}; Reference proteome {ECO:0000313|Proteomes:UP000063699}.
FT DOMAIN 464..738
FT /note="UvrD-like helicase ATP-binding"
FT /evidence="ECO:0000259|PROSITE:PS51198"
FT DOMAIN 739..1020
FT /note="UvrD-like helicase C-terminal"
FT /evidence="ECO:0000259|PROSITE:PS51217"
FT BINDING 485..492
FT /ligand="ATP"
FT /ligand_id="ChEBI:CHEBI:30616"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00560"
SQ SEQUENCE 1020 AA; 111816 MW; 97E6EBBB33637987 CRC64;
MRYYADLHVH SKHSRACSRD CDVRNLAWWA RRKGITVLGT GDFTHPAWAQ ELRETLEPAE
PGLFKLRGDV DADVLRKLPA TCHGDVRFVL EVEISTIYKR DDRTRKVHHL CYVPSFEAAD
KFTAALAKIG NLGSDGRPIL GLDSRDLLEI TLESGEGSYL VPAHVWTPWF AVLGSKSGFD
AVADCYADLA DHVFAVETGL SSDPSMNWRV SGLDAYRLVS NSDAHSPPIL GRNATVFDTE
LDYFALRDAL RDGTGYVGTV DMFPEEGKYF LDGHRKCDVR MEPGETKKLG GVCPSCSKPL
TVGVLHRIAE LADREPGVRP ANAGECWSII PLPEIMGEIL KVGPKSKAVS AAVSDLVHVH
GPELPLLMEA PLDEIRNPLV HEAIDRLRRG QVRCDPGFDG EYGTIKVFAP GELDAPTDRS
PGLFDVPTVE EIVVSRRAIR PLVEITRPVT PVMITPPSTS SLLDGLDPDQ RAAASVVDGQ
VLIVAGPGTG KTRTLTHRIA HLVLSHDVSP DSVLAITFTR RAAEEMRERL AALIPAAAEL
TVATFHQFGM MILREQHAVL GLAPDFGVAD EPTRLAVLRE IVGEEPRRAL QDISRAKRVL
AAELAAAAAG ELPIGDEIDG DLIGLVERYD KALHSKDLVD FDDLLTMPVT LLSRQIELVE
HYRARFSHIC VDEYQDVDEL QYRLLQELTP QNGNLCAIGD PDQAIYSFRG ADVGFFLRFQ
RDFPAARTVQ LTRNYRSSPV IVAGALAAIK PATLVPDREL QAMRTARGDR ERIGVYPAAS
DESEAEFVVR TIEELLGGSS FHAHDSGRVA GDGVDGGLSF DDIAVLYRTD AQAKPVMETL
AREGLPFQKR SHSALAGHPG VRALIEHFVV DSPNTSLLLK QAAQRVPDSV DVQDALELLT
PLAARLDPAA FLAELSLGAE VDTWDPRAEK ISLLTLHASK GLEFPVVFII GCADGTLPMR
WSAETDEERR LFFVGVSRAQ KHLYLSHRGE PSPFLSSLGP QVAEKLANRT ARRSRQLRLL
//
