ID A0A0N9I7M2_9PSEU Unreviewed; 6807 AA.
AC A0A0N9I7M2;
DT 20-JAN-2016, integrated into UniProtKB/TrEMBL.
DT 20-JAN-2016, sequence version 1.
DT 27-MAR-2024, entry version 38.
DE RecName: Full=Beta-ketoacyl synthase {ECO:0008006|Google:ProtNLM};
GN ORFNames=AOZ06_39640 {ECO:0000313|EMBL:ALG12163.1};
OS Kibdelosporangium phytohabitans.
OC Bacteria; Actinomycetota; Actinomycetes; Pseudonocardiales;
OC Pseudonocardiaceae; Kibdelosporangium.
OX NCBI_TaxID=860235 {ECO:0000313|EMBL:ALG12163.1, ECO:0000313|Proteomes:UP000063699};
RN [1] {ECO:0000313|EMBL:ALG12163.1, ECO:0000313|Proteomes:UP000063699}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=KLBMP1111 {ECO:0000313|EMBL:ALG12163.1,
RC ECO:0000313|Proteomes:UP000063699};
RA Qin S., Xing K.;
RT "Genome sequencing of Kibdelosporangium phytohabitans.";
RL Submitted (JUL-2015) to the EMBL/GenBank/DDBJ databases.
CC -!- PATHWAY: Antibiotic biosynthesis. {ECO:0000256|ARBA:ARBA00004792}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; CP012752; ALG12163.1; -; Genomic_DNA.
DR RefSeq; WP_054294059.1; NZ_JADBEI010000001.1.
DR STRING; 860235.AOZ06_39640; -.
DR KEGG; kphy:AOZ06_39640; -.
DR Proteomes; UP000063699; Chromosome.
DR GO; GO:0004315; F:3-oxoacyl-[acyl-carrier-protein] synthase activity; IEA:InterPro.
DR GO; GO:0031177; F:phosphopantetheine binding; IEA:InterPro.
DR GO; GO:0017000; P:antibiotic biosynthetic process; IEA:UniProtKB-KW.
DR GO; GO:0006633; P:fatty acid biosynthetic process; IEA:InterPro.
DR CDD; cd08956; KR_3_FAS_SDR_x; 4.
DR CDD; cd00833; PKS; 4.
DR Gene3D; 3.30.70.3290; -; 4.
DR Gene3D; 3.40.47.10; -; 4.
DR Gene3D; 1.10.1200.10; ACP-like; 4.
DR Gene3D; 3.40.366.10; Malonyl-Coenzyme A Acyl Carrier Protein, domain 2; 4.
DR Gene3D; 3.40.50.720; NAD(P)-binding Rossmann-like Domain; 4.
DR Gene3D; 3.10.129.110; Polyketide synthase dehydratase; 4.
DR InterPro; IPR001227; Ac_transferase_dom_sf.
DR InterPro; IPR036736; ACP-like_sf.
DR InterPro; IPR014043; Acyl_transferase.
DR InterPro; IPR016035; Acyl_Trfase/lysoPLipase.
DR InterPro; IPR018201; Ketoacyl_synth_AS.
DR InterPro; IPR014031; Ketoacyl_synth_C.
DR InterPro; IPR014030; Ketoacyl_synth_N.
DR InterPro; IPR016036; Malonyl_transacylase_ACP-bd.
DR InterPro; IPR036291; NAD(P)-bd_dom_sf.
DR InterPro; IPR032821; PKS_assoc.
DR InterPro; IPR020841; PKS_Beta-ketoAc_synthase_dom.
DR InterPro; IPR042104; PKS_dehydratase_sf.
DR InterPro; IPR020807; PKS_DH.
DR InterPro; IPR049551; PKS_DH_C.
DR InterPro; IPR049552; PKS_DH_N.
DR InterPro; IPR013968; PKS_KR.
DR InterPro; IPR020806; PKS_PP-bd.
DR InterPro; IPR009081; PP-bd_ACP.
DR InterPro; IPR006162; Ppantetheine_attach_site.
DR InterPro; IPR016039; Thiolase-like.
DR PANTHER; PTHR43775; FATTY ACID SYNTHASE; 1.
DR PANTHER; PTHR43775:SF51; PHENOLPHTHIOCEROL_PHTHIOCEROL POLYKETIDE SYNTHASE SUBUNIT E; 1.
DR Pfam; PF00698; Acyl_transf_1; 4.
DR Pfam; PF16197; KAsynt_C_assoc; 4.
DR Pfam; PF00109; ketoacyl-synt; 4.
DR Pfam; PF02801; Ketoacyl-synt_C; 4.
DR Pfam; PF08659; KR; 4.
DR Pfam; PF21089; PKS_DH_N; 4.
DR Pfam; PF00550; PP-binding; 4.
DR Pfam; PF14765; PS-DH; 4.
DR SMART; SM00827; PKS_AT; 4.
DR SMART; SM00826; PKS_DH; 4.
DR SMART; SM00822; PKS_KR; 4.
DR SMART; SM00825; PKS_KS; 4.
DR SMART; SM00823; PKS_PP; 4.
DR SMART; SM01294; PKS_PP_betabranch; 4.
DR SUPFAM; SSF47336; ACP-like; 4.
DR SUPFAM; SSF52151; FabD/lysophospholipase-like; 4.
DR SUPFAM; SSF51735; NAD(P)-binding Rossmann-fold domains; 8.
DR SUPFAM; SSF55048; Probable ACP-binding domain of malonyl-CoA ACP transacylase; 4.
DR SUPFAM; SSF53901; Thiolase-like; 4.
DR PROSITE; PS50075; CARRIER; 4.
DR PROSITE; PS00606; KS3_1; 4.
DR PROSITE; PS52004; KS3_2; 4.
DR PROSITE; PS00012; PHOSPHOPANTETHEINE; 4.
PE 4: Predicted;
KW Antibiotic biosynthesis {ECO:0000256|ARBA:ARBA00023194};
KW Phosphopantetheine {ECO:0000256|ARBA:ARBA00022450};
KW Phosphoprotein {ECO:0000256|ARBA:ARBA00022553};
KW Reference proteome {ECO:0000313|Proteomes:UP000063699};
KW Transferase {ECO:0000256|ARBA:ARBA00022679}.
FT DOMAIN 29..451
FT /note="Ketosynthase family 3 (KS3)"
FT /evidence="ECO:0000259|PROSITE:PS52004"
FT DOMAIN 1590..1665
FT /note="Carrier"
FT /evidence="ECO:0000259|PROSITE:PS50075"
FT DOMAIN 1683..2106
FT /note="Ketosynthase family 3 (KS3)"
FT /evidence="ECO:0000259|PROSITE:PS52004"
FT DOMAIN 3270..3352
FT /note="Carrier"
FT /evidence="ECO:0000259|PROSITE:PS50075"
FT DOMAIN 3370..3793
FT /note="Ketosynthase family 3 (KS3)"
FT /evidence="ECO:0000259|PROSITE:PS52004"
FT DOMAIN 4971..5046
FT /note="Carrier"
FT /evidence="ECO:0000259|PROSITE:PS50075"
FT DOMAIN 5065..5481
FT /note="Ketosynthase family 3 (KS3)"
FT /evidence="ECO:0000259|PROSITE:PS52004"
FT DOMAIN 6659..6734
FT /note="Carrier"
FT /evidence="ECO:0000259|PROSITE:PS50075"
FT REGION 1560..1584
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 6025..6044
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 6807 AA; 711137 MW; 12CDA67ED4F55E24 CRC64;
MSDEGRLFEY LKRVTADLRQ ARGELAGHRE PIAIVGMACR FPGGVTTPEQ LWDLVSAGGD
AMGEMPDDRG WDLAGLYHPD PEHTGTTYTR AGGFLPDPGG FDAEFFGITP REAMATDPQQ
RILLEVTWEA LERAGIPADS RRGSRVGVFV GTSGQDYATL PSSPQVEGYL AAGNAASLMS
GRIAYSFGFN GPAATVDTAC SSSLVAMHLA AQALRNGECS LAVAGGVTLM TSPNLLVEFA
RQRGLSPDGR CKAFAAAADG TGFADGVGVL LLARLSDAER EGLPVLAVIR GSAVNSDGAS
NGLTAPNGRA QEQVIRQALA NAGLSLSDVD AVEAHGTGTT LGDPIEAEAL LATYGQGRDE
PLWLGSVKSN IGHTQAAAGV AGVIKMVMAF RNGLLPRTLH VDSPTPHVDW TSGQVRLLTE
NQPWPEAGRP RRAAVSSFGV SGTNAHLILE QAVTRVQAAA PADRVVPLLL SARTEPALRD
QARRLLTALR DDMSVVDIGH TLATGRSALE YRAQVVAGDV DDLRAVLAAV ADGGGQVGVV
DNPGRVAFVF SGQGAQRLDM GTVLYQAFPV FADAFDEVCS RLDPGLREVV RSDRHRLDRT
EFAQQALFAF EVALARLFES IGVRPSVVAG HSVGEVAAAH VAGVLDLDDA CALVAARSRL
MQECRQDGVM AAVQASEEEI HEHLSGEVAL AAVNAPQAVV ISGDADAVRR VADHWASLGR
KTTELRVSHA FHSHHMDQAL PGFRQALAGL TFRSPSIAMV PTSNGDVTTA EYWVAQLRSP
VRFEHAVRTM AERGTSVFLE VGPGAPLTAL GGHFDSGAAF IAAQRDKGEE ANNLASALAQ
LHVAGVRWEW DAAFPGGRKI QLPTYAFQHE HYWMPPTSGA GDVETAGLLT AGHPLLSAVT
DLGDDGCVLT GRVSLSTHSW LAEHRILGTV VVPGTALVEM AVSAGRRFGC AHLAELTSRT
PLTLPETEAV VVQVRVGAGG DSRPVSISSR AVDSAEWTLH AEGVLTEDSA VGDESYPTAW
PPAGTSPVDV TTVYDRLSDD GYGYGSVFRG LRAAWRRGDE LFAEVAVPED TDVAGFDVHP
ALLDAALHVM LVDAREGQVW LPFSWSGVSV WPGTPRRLRV RVSPVTRDTV SVLVTDTAGE
PVAAVRRLTG RAASARDIQP ARVNVRDWLL RPDWLPVRTP QGAARFTWLG PDADLASITA
PGDVAVVVGA DGDAMTAGYA GVHRVLTLVR QWLRDERFAS ARLVVVVRPA DWAAAGVWGL
VRSAQTEHPG RFVLVESDAT GEALLPAALA GGEPQLAIRE GRVLVPRLVR AQAGGEPVAL
NPGGTVLITG GTGVLGGLLA RHLVAEHGVR HLVLAGRSGR ADVADLDADV RVVACDVSDR
DDVRLLLDGI PAEHPLTAVI HAAGVLDDGV VETMTSQRIV DVFGPKVGGA WHLHELTEEL
DLEAFVVFSS AAGLLGSGGQ ANYAAANTFL DAIAVHRRSQ GLAAHSLAWG MWEPNGGMTG
GLDATSRARF ARGGIAPFTA TDGLALFDLA LSTDDAVLAP ARFDLTNVPD PAPAVLRELV
RRSTSNPVPN PGSRSPRDRM ARLSPPERQD AVLALVRDQV AVVVGYPDGA AVDADRPFKD
LGFDSLMSVE LRNGLVSLTG VRLSATAVFD YPTPRGLAVH LHAALFGADE KLPRQVTAVV
QDDDPIVIVG MACRYPGGIT SPEDLWDLVA AGTDAVSEFP ADRGWDPGLY DPEPGRTGHS
YTRHGGFLHD AADFDAEFFG ISPREALAMD PQQRLLLEVS WEVVERAGID PVSLRGSRTG
VFVGVMYHDY GTRIGAVADD VEGYVGTGTS GSVASGRVAY TLGLEGPAVT VDTACSSSLV
ALHLAAQALR SGECDLALAG GVTVMATPTT FVDFSRQRGL APDGRCKSFA AGADGTGWSE
GAGLLLVQRL SDARRDGRRV LGVVRGSAVN QDGASNGLTA PNGPSQQRVI RAALAGAGLG
VSDVDVVEAH GTGTRLGDPI EAQALLATYG QGRVRPLLLG SIKSNLGHTQ AAAGVAGVIK
MVMAMRHGVL PRSLHVDEPT PHVDWTAGSV ELLTERVVWP EVDRPRRAGV SSFGISGTNA
HIIIEQVPTG EEPTDNTPAT PLPWVLSAKS DRALRVQAER LRTWASRSPG SSVADIGYSL
ATGRAALNHR AVVVGTDRSD FLRGLETIAT GTSPGDRIAE GIAGSGKLAL LFPGQGSQVV
GMGRGLAESF PVFGSVFGEV CGLVDAELGG SLAEVLWGGD GGVVDRTVFA QVGLFAVEVS
LFRLLESWGV RPDYLVGHSV GEVAAACVSG VLSLGDAVRL VVARGRLMQG LPGGGAMVSV
AAPVAEVVAR VEGVSGVGVA AVNGPRQVVV SGVESVVLGV VEGFAAEGVR TRRLRVSHAF
HSSLMEPMLV EFERVVGGLS FGEPRIPVVS TVGAGLDMST PQYWVRQVRE PVLFADAVAR
VAEQGVTRFV EAGPGSALST MVESCLADLE EGAAVALLRR NQPESQSVID GIARLYVNGV
PLSLAPVFGR ARTVDLPTYA FHRKRYWPTG DAVATGSAGS GHPLLSAAVV LADSGGALLT
GKLSLASHQW LVDHAVRGVS LFPGTGFVEL AAHAGGCVDY PVVDELTIQA PLAMPEQGAV
ELQISVGEEK SGQREVRVYS RIAGASADQS WTCHASGTLV PARPATRRDD VTSWPPSGAR
AVDVDGLYED LAAAGLDYGP AFHGVQRVWR RDHELFAELA LPDGDLVGGS RFGLHPALFD
AALHVARLSD RAWDGTGSKL PFSWSGFELN KAGATELRLK LTSTDSGALS LAMNDIDGSP
VASVESVVLR PVTAEQLAAA QTGHSEPMHR SEWVAVTTPA GAVQSWAWWG LESLANANAD
VIVLPFLTGS DHDDTVDRVH ATTTAALDAV QQWLSDVRFG SSKLVVLTQN AVSAGGSSRP
VDLAGAAVWG LIRSAQLEHP GRIVLVDVDE PDEAAAALAS ALRTGENQVA IRGDSVLGHR
LVPVVRTTVD EVPAWRGTVL VTGGTGGLGA LIARHLVTVH GVERLVLVSR RGTDAPGAAE
LVDELTALGA HVDVAACDTS DRAALAQVLA TIPADHPLGG IVHTAGVLDD GVLTALSPER
LALVLRPKVD AAWHLHELTK DSDLGAFVLF SSAAGVIGAA GQANYAAANA FLDALAVHRR
EQDLPGQSLA WGLWANTDGG MATRMSEADT ERLTRAGVTA LSAPEGLALF DAAGRNGHPV
LVPMRLAPAK RARETAPAGG TTFRRQLSGM DASARLRTVQ DLVLAQTAAV LGHASAAEIH
PGRAFQGLGF DSLTAVELRN GLSTATRLRL PATLVFDHPN PAALAEYLVS ELVGEPAESE
VGEAPQVLDD DPIVIVGMAC RYPGGITSPE DLWRLVSTDG DAISEFPADR GWDGDGLYDP
DASRYGKSAT RHGGFLHDAA DFDAGFFGIS PREALAMDPQ QRLLLEVSWE VVERAGIDPV
SLRGSRTGVF AGVMYHDYGA RMADVDDAEG YVGTGNSGSI ASGRVAYALG FEGPAVTVDT
ACSSSLVALH LAAQALRTGE CDLALAGGVT VMATPAAFVG FSRQGGLSPD GRCKSFAAGA
DGTGWSEGVG LLLVQRLSDA RRDGRRVLGV VRGSAVNQDG ASNGLTAPNG PSQQRVIRAA
LRNSGLSAVD VDAVEAHGTG TKLGDPIEAQ ALLATYGQGR VRPLLLGSIK SNLGHTQAAA
GVAGVIKMVM AMRHGVLPRS LHVDEPTPHV DWTAGSVELL TERVVWPEVD RPRRAGVSSF
GISGTNAHVI IEQPSEPTAE SSAADPDLVV WSVSARSPEA LRAQANRLLS HVDAHPETAA
GEVGRSLATA RAHLEFRASV IGADREELRH GLAAVAAGEL VDGIFAGREQ TGSTGFLFPG
QGSQVVGMGR GLAESFPVFG SVFGEVCGLV DAELGGSLAE VLWGGDGGVV DRTVFAQVGL
FAVEVSLFRL LESWGVRPDY LVGHSVGEVA AACVSGVLSL GDAVRLVVAR GRLMQGLPGG
GAMVSVAAPV AEVVARVEGV SGVGVAAVNG PRQVVVSGVE SVVLGVVEGF AAEGVRTRRL
RVSHAFHSSL MEPMLVEFER VVGGLSFGAP RIPVVSTVGA GLDMSTPQYW VRQVREPVLF
ADAVNHLAAE GVRRFVEIGP GTALTVLAKE NLVDSQAVVL PTLRRGEDEP RQVVEAIAGL
HVSGASLEWA RFFAGVNQVD LPTYAFQHRR YWYDVPVGQP GDIRNVGQQA VTHPLLGAAV
ALPATGGMAF TGRLSVATQL WLADHLVAGI VLFPATGFVE LARHAGDELG CPVVEELSIQ
APLVMPANAA VSVQVSVGQV GDDGRRTVSV YSRPEDTAAD QRWTCHATGE LASPIAIPLQ
QDSSAWPPVG ALAVDPDALY DKLAARGLDY GPVFRGVRAA WQRGEELFAE VDLPEDEHPA
ATRYGLHPAL FDAALHVAAV NGEAAALPFA WTGVTLHAAG ATALRVSVVT SGENTMAIHL
ATQDGIPVAD VGSLVSRPIS PEQLAAARTD HDDLLFRRNW VPITPPQPTA EPETWSWYAQ
DGPVADVLVI AFTAGGASDV PAEVHHDTRR ALAVLRDWST DERYGSSRLV VLAHGITAGT
DEPSLAAVCG LVRSAQSENT PGRITLLHTD DLARPIDDLV AVTKAAAEPE LLVRGDAVLV
PRLARLTTPA TATAPDWSAG TTLVTGGTGG LGAALARHLV VEHGARHLAL VSRRGLEAPG
AGQLVAELGE LGAHVSVAAC DVADRSALAE VLATIPADHP LVGVVHAAGV LDDGLVTALS
DEQLETVLRP KVDAAWHLHE LTQDLDLSAF VMFSSAAGVL GAAGQANYAA ANAFLDALAT
YRRAQGLAGQ SMAWGLWADD TGMSAGLSGP DVRRLARTGV VPLTTPVGLS LFDTGSRHDE
AVLIPMHMNL NGIGAIPPML QGLVRPRVSA ARAVTVDKSL RERLLLLPES ERGAAVLAVV
CEQVAAVSGG GAIDPDRSFR DLGFDSLMAV ELRNALTEVC GAKLSATAVF DYPTPRDLAA
HVRGDLDGTR EQVILPTPAV TRDLDDPVVI VGMACRYPGG VSSPDELWQL VVDGADAISD
FPQDRGWTTG SGSSYPRAGG FLHSAADFDA EFFGISPREA LAMDPQQRLM LEVSWEAFEH
AGIDPASLRG SRTGVFAGLM YHDYASRAQG SLSEDLVGFL GNGNSGSVLS GRVAYSLGLE
GPAVTVDTAC SSSLVALHLA AQALRSGECD LALAGGVTVM ATPAAFVEFG RQGALASDGR
CKAFSDTADG TAWSEGVGLL LVQRLSDARR DGRRVLGVVR GSAVNQDGAS NGLTAPNGPS
QQRVIRAALA GAGLGVSDVD VVEAHGTGTA LGDPIEAQAL IATYGQGRVR PLLLGSIKSN
LGHTQAAAGV AGVIKMVMAM RHGVLPRTLH VDEPTSHVDW SAGSVQLVTE QVVWPEVDRP
RRAGVSSFGI SGTNAHVIIE APVAGESPTN NEMRAVPWLL SAKNEEALRA QARRLLTYTE
VHPDTDPADV ANVLATKRAV HKHRFALVGD SLDALTKRLR AFVDGEAGSV VADQGMVALL
FSGQGSQVVG MGRGLAESFP VFGSVFGEVC GLVDAELGGS LAEVLWGGDG GVVDRTVFAQ
VGLFAVEVSL FRLLESWGVR PDYLVGHSVG EVAAACVSGV LSLGDAVRLV VARGRLMQGL
PGGGAMVSVA APVAEVVARV EGVSGVGVAA VNGPRQVVVS GVESVVLGVV EGFAAEGVRT
RRLRVSHAFH SSLMEPMLVE FERVVGGLSF GEPRIPVVST VTGAVISDEF GTPGYWVRQV
REPVLFADAV RSLESLGVTR FVEVGPGSAL TALVHDCLSS DRATLVVPTL RRDTDESSSV
VEAAASLHTA GSVVDWKRFF TDVPARYIDL PTYAFQRKRF WLNAPAAAGD ATGLGQVAAD
HPLIAAAVTL PESDSVVFTG RLSLATHPWL ADHAISGVSV LPVSALVELV TRAGDEVSTA
TVDNLTALVP LVIPESDSVR IQVSVGPPDD SGRRPVSVFS TTESADQDWT RNARGVLSAD
ARPFEFGVTT WPPADAEAID LDELYDEMAV DHGPAFHGVR AAWRRGGELF AEVVLPEEEQ
LTAARYGLHP ALLDAATHVA AVEFPGAVPA TWTGLSRYAS GVAELRVRLS KTDGATLSFD
AVDFAGTPVA SAEGVALRPA DQVRMPGGRA SDSMFRVEWQ PRPVNESVGS ANPWLVLDER
FAQSLASSGI PVSAAVDEPD IVVLACAGEQ RTTHAVVSDV LAAIQRWLAD ERRAASRLVV
VTRGAVPVGE LTDLAGAAVW GLVRSAQTEH PGRIVLADVD DSLDALPAAL ATGEPQFALR
GGAIHVPRLV RVRAPAATDR ITGGTILVTG GTGGLGALVA RHLVTEHGVQ RLLLVSRRGP
DAPGAGELAA ELRDLGAEVT VAACDVSDVS ALADLLADIP ADFPLTGVVH AAGVLDDGVL
TAMTDDRLAT VLRPKADAAL ALHELTKDMD LSLFALFSSV TGVLGAAGQS NYAAANAFLD
ALAEHRRAQG LVAQSLAWGL WEDQEGGMAK TLTAADVRRQ SRGGVVPLSA AEGLALFDAA
VSSDGTVVVP VRLRTAGVTG EIPPLLEGLV RPRRDERAPA SAKSLRERLS TANENEQYAL
VLGVVRSQIA TVLGHDGAHA IEPDKAFREL GFDSLAAVEL RNGLNTAVGL SLPTSMVFDY
PTPAALSRHL HTELVSGTRG AADPDDGIRQ VLAGIPVDRI RQAGVLEILL RLADPASDVP
PGAGSSTSID DMDAESLLRL AAENSSG
//
