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Entry: A0A0N9V5Q3_9GAMM
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ID   A0A0N9V5Q3_9GAMM        Unreviewed;       259 AA.
AC   A0A0N9V5Q3;
DT   20-JAN-2016, integrated into UniProtKB/TrEMBL.
DT   20-JAN-2016, sequence version 1.
DT   24-JAN-2024, entry version 27.
DE   RecName: Full=Uroporphyrinogen-III synthase {ECO:0000256|ARBA:ARBA00040167, ECO:0000256|RuleBase:RU366031};
DE            EC=4.2.1.75 {ECO:0000256|ARBA:ARBA00013109, ECO:0000256|RuleBase:RU366031};
GN   ORFNames=AOY20_02875 {ECO:0000313|EMBL:ALH94565.1};
OS   Acinetobacter equi.
OC   Bacteria; Pseudomonadota; Gammaproteobacteria; Moraxellales; Moraxellaceae;
OC   Acinetobacter.
OX   NCBI_TaxID=1324350 {ECO:0000313|EMBL:ALH94565.1, ECO:0000313|Proteomes:UP000064939};
RN   [1] {ECO:0000313|EMBL:ALH94565.1, ECO:0000313|Proteomes:UP000064939}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=114 {ECO:0000313|EMBL:ALH94565.1,
RC   ECO:0000313|Proteomes:UP000064939};
RX   PubMed=26620413;
RA   Poppel M.T., Skiebe E., Laue M., Bergmann H., Ebersberger I., Garn T.,
RA   Fruth A., Baumgardt S., Busse H.J., Wilharm G.;
RT   "Acinetobacter equi sp. nov. isolated from horse faeces.";
RL   Int. J. Syst. Evol. Microbiol. 0:0-0(2015).
CC   -!- FUNCTION: Catalyzes cyclization of the linear tetrapyrrole,
CC       hydroxymethylbilane, to the macrocyclic uroporphyrinogen III.
CC       {ECO:0000256|ARBA:ARBA00037589, ECO:0000256|RuleBase:RU366031}.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=hydroxymethylbilane = H2O + uroporphyrinogen III;
CC         Xref=Rhea:RHEA:18965, ChEBI:CHEBI:15377, ChEBI:CHEBI:57308,
CC         ChEBI:CHEBI:57845; EC=4.2.1.75;
CC         Evidence={ECO:0000256|ARBA:ARBA00000783,
CC         ECO:0000256|RuleBase:RU366031};
CC   -!- PATHWAY: Porphyrin-containing compound metabolism; protoporphyrin-IX
CC       biosynthesis; coproporphyrinogen-III from 5-aminolevulinate: step 3/4.
CC       {ECO:0000256|ARBA:ARBA00004772, ECO:0000256|RuleBase:RU366031}.
CC   -!- SIMILARITY: Belongs to the uroporphyrinogen-III synthase family.
CC       {ECO:0000256|ARBA:ARBA00008133, ECO:0000256|RuleBase:RU366031}.
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DR   EMBL; CP012808; ALH94565.1; -; Genomic_DNA.
DR   RefSeq; WP_054580468.1; NZ_CP012808.1.
DR   AlphaFoldDB; A0A0N9V5Q3; -.
DR   STRING; 1324350.AOY20_02875; -.
DR   KEGG; aei:AOY20_02875; -.
DR   OrthoDB; 9787650at2; -.
DR   UniPathway; UPA00251; UER00320.
DR   Proteomes; UP000064939; Chromosome.
DR   GO; GO:0004852; F:uroporphyrinogen-III synthase activity; IEA:UniProtKB-UniRule.
DR   GO; GO:0006782; P:protoporphyrinogen IX biosynthetic process; IEA:UniProtKB-UniRule.
DR   GO; GO:0006780; P:uroporphyrinogen III biosynthetic process; IEA:UniProtKB-UniRule.
DR   CDD; cd06578; HemD; 1.
DR   Gene3D; 3.40.50.10090; -; 2.
DR   InterPro; IPR036108; 4pyrrol_syn_uPrphyn_synt_sf.
DR   InterPro; IPR003754; 4pyrrol_synth_uPrphyn_synth.
DR   InterPro; IPR039793; UROS/Hem4.
DR   PANTHER; PTHR38042; UROPORPHYRINOGEN-III SYNTHASE, CHLOROPLASTIC; 1.
DR   PANTHER; PTHR38042:SF1; UROPORPHYRINOGEN-III SYNTHASE, CHLOROPLASTIC; 1.
DR   Pfam; PF02602; HEM4; 1.
DR   SUPFAM; SSF69618; HemD-like; 1.
PE   3: Inferred from homology;
KW   Lyase {ECO:0000256|ARBA:ARBA00023239, ECO:0000256|RuleBase:RU366031};
KW   Porphyrin biosynthesis {ECO:0000256|ARBA:ARBA00023244,
KW   ECO:0000256|RuleBase:RU366031}.
FT   DOMAIN          14..216
FT                   /note="Tetrapyrrole biosynthesis uroporphyrinogen III
FT                   synthase"
FT                   /evidence="ECO:0000259|Pfam:PF02602"
SQ   SEQUENCE   259 AA;  29908 MW;  AEAD25BD63F29DDB CRC64;
     MLFINTRPLE RAEALSSALL NFNIDVINFP LLELKEHPFS SELQYLYHQL LDASVIVVVS
     PTAVEVGMKF LHKCKIELSD LSQIQWIAVG EKTAEELKKY QIESFIPSVE TSEGMLQLPI
     LDTLNKGAKV AFWRGEGGRQ FMMESLRQNG MDVLNFILYE RQLPEESQVQ SQQLIAMIQD
     KKSYIALITS EASWLNWLDV LKTHSDLIDQ GQYWVLGDRL FNILNFYKKQ QNLDYSIVKL
     MNLKIESILL HIDEIQGRL
//
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