ID A0A0P0A5M8_9RHOB Unreviewed; 632 AA.
AC A0A0P0A5M8;
DT 20-JAN-2016, integrated into UniProtKB/TrEMBL.
DT 20-JAN-2016, sequence version 1.
DT 27-MAR-2024, entry version 35.
DE RecName: Full=DNA mismatch repair protein MutL {ECO:0000256|ARBA:ARBA00021975, ECO:0000256|HAMAP-Rule:MF_00149};
GN Name=mutL {ECO:0000256|HAMAP-Rule:MF_00149};
GN ORFNames=IMCC12053_1961 {ECO:0000313|EMBL:ALI55908.1},
GN SAMN05444421_11015 {ECO:0000313|EMBL:SFK88861.1};
OS Celeribacter marinus.
OC Bacteria; Pseudomonadota; Alphaproteobacteria; Rhodobacterales;
OC Roseobacteraceae; Celeribacter.
OX NCBI_TaxID=1397108 {ECO:0000313|EMBL:ALI55908.1, ECO:0000313|Proteomes:UP000064920};
RN [1] {ECO:0000313|EMBL:ALI55908.1, ECO:0000313|Proteomes:UP000064920}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=IMCC 12053 {ECO:0000313|EMBL:ALI55908.1,
RC ECO:0000313|Proteomes:UP000064920};
RA Wang D.B., Wang M.;
RL Submitted (MAY-2015) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|EMBL:SFK88861.1, ECO:0000313|Proteomes:UP000181863}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=DSM 100036 {ECO:0000313|EMBL:SFK88861.1,
RC ECO:0000313|Proteomes:UP000181863};
RA Varghese N., Submissions S.;
RL Submitted (OCT-2016) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: This protein is involved in the repair of mismatches in DNA.
CC It is required for dam-dependent methyl-directed DNA mismatch repair.
CC May act as a 'molecular matchmaker', a protein that promotes the
CC formation of a stable complex between two or more DNA-binding proteins
CC in an ATP-dependent manner without itself being part of a final
CC effector complex. {ECO:0000256|HAMAP-Rule:MF_00149}.
CC -!- SIMILARITY: Belongs to the DNA mismatch repair MutL/HexB family.
CC {ECO:0000256|ARBA:ARBA00006082, ECO:0000256|HAMAP-Rule:MF_00149}.
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DR EMBL; CP012023; ALI55908.1; -; Genomic_DNA.
DR EMBL; FOSM01000010; SFK88861.1; -; Genomic_DNA.
DR RefSeq; WP_062218504.1; NZ_FOSM01000010.1.
DR AlphaFoldDB; A0A0P0A5M8; -.
DR STRING; 1397108.IMCC12053_1961; -.
DR KEGG; cmar:IMCC12053_1961; -.
DR PATRIC; fig|1397108.4.peg.2004; -.
DR OrthoDB; 9763467at2; -.
DR Proteomes; UP000064920; Chromosome.
DR Proteomes; UP000181863; Unassembled WGS sequence.
DR GO; GO:0032300; C:mismatch repair complex; IEA:InterPro.
DR GO; GO:0005524; F:ATP binding; IEA:InterPro.
DR GO; GO:0016887; F:ATP hydrolysis activity; IEA:InterPro.
DR GO; GO:0140664; F:ATP-dependent DNA damage sensor activity; IEA:InterPro.
DR GO; GO:0030983; F:mismatched DNA binding; IEA:InterPro.
DR GO; GO:0006298; P:mismatch repair; IEA:UniProtKB-UniRule.
DR CDD; cd16926; HATPase_MutL-MLH-PMS-like; 1.
DR CDD; cd03482; MutL_Trans_MutL; 1.
DR Gene3D; 3.30.230.10; -; 1.
DR Gene3D; 3.30.565.10; Histidine kinase-like ATPase, C-terminal domain; 1.
DR Gene3D; 3.30.1540.20; MutL, C-terminal domain, dimerisation subdomain; 1.
DR Gene3D; 3.30.1370.100; MutL, C-terminal domain, regulatory subdomain; 1.
DR HAMAP; MF_00149; DNA_mis_repair; 1.
DR InterPro; IPR014762; DNA_mismatch_repair_CS.
DR InterPro; IPR020667; DNA_mismatch_repair_MutL.
DR InterPro; IPR013507; DNA_mismatch_S5_2-like.
DR InterPro; IPR036890; HATPase_C_sf.
DR InterPro; IPR002099; MutL/Mlh/PMS.
DR InterPro; IPR038973; MutL/Mlh/Pms-like.
DR InterPro; IPR014790; MutL_C.
DR InterPro; IPR042120; MutL_C_dimsub.
DR InterPro; IPR042121; MutL_C_regsub.
DR InterPro; IPR037198; MutL_C_sf.
DR InterPro; IPR020568; Ribosomal_Su5_D2-typ_SF.
DR InterPro; IPR014721; Ribsml_uS5_D2-typ_fold_subgr.
DR NCBIfam; TIGR00585; mutl; 1.
DR PANTHER; PTHR10073; DNA MISMATCH REPAIR PROTEIN MLH, PMS, MUTL; 1.
DR PANTHER; PTHR10073:SF12; DNA MISMATCH REPAIR PROTEIN MLH1; 1.
DR Pfam; PF01119; DNA_mis_repair; 1.
DR Pfam; PF13589; HATPase_c_3; 1.
DR Pfam; PF08676; MutL_C; 1.
DR SMART; SM01340; DNA_mis_repair; 1.
DR SMART; SM00853; MutL_C; 1.
DR SUPFAM; SSF55874; ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase; 1.
DR SUPFAM; SSF118116; DNA mismatch repair protein MutL; 1.
DR SUPFAM; SSF54211; Ribosomal protein S5 domain 2-like; 1.
DR PROSITE; PS00058; DNA_MISMATCH_REPAIR_1; 1.
PE 3: Inferred from homology;
KW DNA damage {ECO:0000256|ARBA:ARBA00022763, ECO:0000256|HAMAP-
KW Rule:MF_00149};
KW DNA repair {ECO:0000256|ARBA:ARBA00023204, ECO:0000256|HAMAP-
KW Rule:MF_00149}; Reference proteome {ECO:0000313|Proteomes:UP000064920}.
FT DOMAIN 229..347
FT /note="DNA mismatch repair protein S5"
FT /evidence="ECO:0000259|SMART:SM01340"
FT DOMAIN 446..589
FT /note="MutL C-terminal dimerisation"
FT /evidence="ECO:0000259|SMART:SM00853"
SQ SEQUENCE 632 AA; 68084 MW; 28008E4282E06720 CRC64;
MNSPRPNISQ DSRPTIRQLD EGAINRIAAG EVVERPASAV KELVENAVDA GARRIEVDYA
DGGKTLIRVT DDGCGMTADD LPLALSRHAT SKIDGSDLLD IHTFGFRGEA LPSLGAVGRL
KITSRVEGGD GVSLTVSGGR AEPVKPAALS KGTIVELRDL FYATPARLKF LRTDRAESQA
IGDVIKRLAM AEPFVGFTVR DVSGGGEGRV TFRADPESGD LFDALHGRLA QVLGKDFAQN
ALAIDAQREG MHLTGYAALP TYSRGSAVTQ FLFVNGRPVK DKLLVGALRG AYFDFLSRDR
HPAACLFIDC DPHLVDVNVH PAKSEVRFRD PALARGLIVS ALRHALAEAG HRASTTVAIA
TLDAMRPEGQ GNTPRVYQMD QRSVVGRDGG FVRTPHPSSD AIEQSYQWQS PQRFDTPGFS
ESAPPSARFE DVQSAPEVEA LPLGAARAQV HENYIIAQTE RGIVLVDQHA AHERLVYEKL
KAQMAANGVA SQALLIPEVV ELGSNDAQTL LDLADDLSRL GLVIEPFGGG AIAVRETPAI
LGRVDAKAMI SDILDELEDV GDSLSVQARI EAVLSRVACH GSIRSGRRMR AEEMNALLRE
MEATPHSGQC NHGRPTYVEL KLSDIERLFG RT
//
