ID A0A0P0D6W2_9FLAO Unreviewed; 580 AA.
AC A0A0P0D6W2;
DT 20-JAN-2016, integrated into UniProtKB/TrEMBL.
DT 20-JAN-2016, sequence version 1.
DT 24-JAN-2024, entry version 25.
DE SubName: Full=Alkaline phosphatase {ECO:0000313|EMBL:ALJ06673.1};
GN ORFNames=APS56_00580 {ECO:0000313|EMBL:ALJ06673.1};
OS Pseudalgibacter alginicilyticus.
OC Bacteria; Bacteroidota; Flavobacteriia; Flavobacteriales;
OC Flavobacteriaceae; Pseudalgibacter.
OX NCBI_TaxID=1736674 {ECO:0000313|EMBL:ALJ06673.1, ECO:0000313|Proteomes:UP000057981};
RN [1] {ECO:0000313|EMBL:ALJ06673.1, ECO:0000313|Proteomes:UP000057981}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=HZ-22 {ECO:0000313|Proteomes:UP000057981};
RA Gilbert D.G.;
RL Submitted (OCT-2015) to the EMBL/GenBank/DDBJ databases.
CC -!- COFACTOR:
CC Name=Mg(2+); Xref=ChEBI:CHEBI:18420;
CC Evidence={ECO:0000256|PIRSR:PIRSR601952-2};
CC Note=Binds 1 Mg(2+) ion. {ECO:0000256|PIRSR:PIRSR601952-2};
CC -!- COFACTOR:
CC Name=Zn(2+); Xref=ChEBI:CHEBI:29105;
CC Evidence={ECO:0000256|PIRSR:PIRSR601952-2};
CC Note=Binds 2 Zn(2+) ions. {ECO:0000256|PIRSR:PIRSR601952-2};
CC -!- SIMILARITY: Belongs to the alkaline phosphatase family.
CC {ECO:0000256|RuleBase:RU003946}.
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DR EMBL; CP012898; ALJ06673.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A0P0D6W2; -.
DR STRING; 1736674.APS56_00580; -.
DR KEGG; ahz:APS56_00580; -.
DR PATRIC; fig|1736674.3.peg.124; -.
DR Proteomes; UP000057981; Chromosome.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0016791; F:phosphatase activity; IEA:InterPro.
DR GO; GO:0008081; F:phosphoric diester hydrolase activity; IEA:InterPro.
DR GO; GO:0006629; P:lipid metabolic process; IEA:InterPro.
DR CDD; cd16012; ALP; 1.
DR CDD; cd08577; PI-PLCc_GDPD_SF_unchar3; 1.
DR Gene3D; 3.40.720.10; Alkaline Phosphatase, subunit A; 1.
DR Gene3D; 3.20.20.190; Phosphatidylinositol (PI) phosphodiesterase; 1.
DR InterPro; IPR039559; AIM6_PI-PLC-like_dom.
DR InterPro; IPR001952; Alkaline_phosphatase.
DR InterPro; IPR017850; Alkaline_phosphatase_core_sf.
DR InterPro; IPR017946; PLC-like_Pdiesterase_TIM-brl.
DR PANTHER; PTHR11596; ALKALINE PHOSPHATASE; 1.
DR PANTHER; PTHR11596:SF5; ALKALINE PHOSPHATASE; 1.
DR Pfam; PF00245; Alk_phosphatase; 3.
DR Pfam; PF13653; GDPD_2; 1.
DR PRINTS; PR00113; ALKPHPHTASE.
DR SMART; SM00098; alkPPc; 1.
DR SUPFAM; SSF53649; Alkaline phosphatase-like; 1.
DR SUPFAM; SSF51695; PLC-like phosphodiesterases; 1.
PE 3: Inferred from homology;
KW Magnesium {ECO:0000256|PIRSR:PIRSR601952-2};
KW Metal-binding {ECO:0000256|PIRSR:PIRSR601952-2};
KW Phosphoprotein {ECO:0000256|ARBA:ARBA00022553};
KW Reference proteome {ECO:0000313|Proteomes:UP000057981};
KW Zinc {ECO:0000256|PIRSR:PIRSR601952-2}.
FT ACT_SITE 310
FT /note="Phosphoserine intermediate"
FT /evidence="ECO:0000256|PIRSR:PIRSR601952-1"
FT BINDING 269
FT /ligand="Mg(2+)"
FT /ligand_id="ChEBI:CHEBI:18420"
FT /evidence="ECO:0000256|PIRSR:PIRSR601952-2"
FT BINDING 269
FT /ligand="Zn(2+)"
FT /ligand_id="ChEBI:CHEBI:29105"
FT /ligand_label="2"
FT /evidence="ECO:0000256|PIRSR:PIRSR601952-2"
FT BINDING 363
FT /ligand="Mg(2+)"
FT /ligand_id="ChEBI:CHEBI:18420"
FT /evidence="ECO:0000256|PIRSR:PIRSR601952-2"
FT BINDING 469
FT /ligand="Mg(2+)"
FT /ligand_id="ChEBI:CHEBI:18420"
FT /evidence="ECO:0000256|PIRSR:PIRSR601952-2"
FT BINDING 474
FT /ligand="Zn(2+)"
FT /ligand_id="ChEBI:CHEBI:29105"
FT /ligand_label="2"
FT /evidence="ECO:0000256|PIRSR:PIRSR601952-2"
FT BINDING 478
FT /ligand="Zn(2+)"
FT /ligand_id="ChEBI:CHEBI:29105"
FT /ligand_label="2"
FT /evidence="ECO:0000256|PIRSR:PIRSR601952-2"
FT BINDING 516
FT /ligand="Zn(2+)"
FT /ligand_id="ChEBI:CHEBI:29105"
FT /ligand_label="2"
FT /evidence="ECO:0000256|PIRSR:PIRSR601952-2"
FT BINDING 517
FT /ligand="Zn(2+)"
FT /ligand_id="ChEBI:CHEBI:29105"
FT /ligand_label="2"
FT /evidence="ECO:0000256|PIRSR:PIRSR601952-2"
SQ SEQUENCE 580 AA; 64732 MW; FDA838E3DD8F0978 CRC64;
MGQEIGLPYK IHSHNDYKQK VPFWTAYSCG LNSIEIDVIL KNDTLFVAHD EVDITSFNTI
ENLYLDPIQK TFQLTPQSYQ QIQLLIDIKT EAIATLKTLI NTLKLYPDIT NSEHISFIVS
GNQPKPESYN NYPSFIKFDY QNLKPLSEEA LNKVGLISLP FSKFSNWNGK GRLTKEDHKK
VSEIINKAHS FNKPFRFWGC PDSKTAWKAF AELGVDYINT DMPYTASTYI HSLSDRIHRN
TFYSTVYKPT FHSIKKNQGV KNIILMIGDG YGLSQISAAA LSNHGELTLT QLKSIGLLKT
QAADDFTTDS AAAGTAIATG EKTYNRSIGM NINRVPIENM TELLNKKNYN TGFITTDVIT
GATPSAFYAH QLDRDMTKEI ASDLIKSNIS LFMGGGASSY SDIFVNSNFT ILNSLNEIAS
SKKKKVGYFL SEKGVPSINS GRDHILAEAT KTGLEYFSNQ NKPFFLMIEA AQIDSFGHRN
DISGIVTEAI DFDKAITEAI KYADTHKNTL VIITADHETS GLSIPQGNLE SNKVEGDFST
YDHTGVMVPI FAYGPKSEVF TGVYENNEVF HKIKDVLNIK
//
