ID A0A0P0D7Y5_9CAUL Unreviewed; 376 AA.
AC A0A0P0D7Y5;
DT 20-JAN-2016, integrated into UniProtKB/TrEMBL.
DT 20-JAN-2016, sequence version 1.
DT 27-MAR-2024, entry version 25.
DE SubName: Full=Cobalamin biosynthesis protein CobW {ECO:0000313|EMBL:ALJ07064.1};
GN ORFNames=JL11_00935 {ECO:0000313|EMBL:ALJ07064.1};
OS Brevundimonas sp. DS20.
OC Bacteria; Pseudomonadota; Alphaproteobacteria; Caulobacterales;
OC Caulobacteraceae; Brevundimonas.
OX NCBI_TaxID=1532555 {ECO:0000313|EMBL:ALJ07064.1, ECO:0000313|Proteomes:UP000059212};
RN [1] {ECO:0000313|EMBL:ALJ07064.1, ECO:0000313|Proteomes:UP000059212}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=DS20 {ECO:0000313|EMBL:ALJ07064.1,
RC ECO:0000313|Proteomes:UP000059212};
RA Scott D., Ely B.;
RT "Conservation of the essential genome among Caulobacter and Brevundimonas
RT species.";
RL Submitted (OCT-2015) to the EMBL/GenBank/DDBJ databases.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=GTP + H2O = GDP + H(+) + phosphate; Xref=Rhea:RHEA:19669,
CC ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:37565,
CC ChEBI:CHEBI:43474, ChEBI:CHEBI:58189;
CC Evidence={ECO:0000256|ARBA:ARBA00001702};
CC PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:19670;
CC Evidence={ECO:0000256|ARBA:ARBA00001702};
CC -!- SIMILARITY: Belongs to the SIMIBI class G3E GTPase family. ZNG1
CC subfamily. {ECO:0000256|ARBA:ARBA00034320}.
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DR EMBL; CP012897; ALJ07064.1; -; Genomic_DNA.
DR RefSeq; WP_054764033.1; NZ_CP012897.1.
DR AlphaFoldDB; A0A0P0D7Y5; -.
DR STRING; 1532555.JL11_00935; -.
DR KEGG; brd:JL11_00935; -.
DR Proteomes; UP000059212; Chromosome.
DR GO; GO:0016787; F:hydrolase activity; IEA:UniProtKB-KW.
DR CDD; cd03112; CobW-like; 1.
DR Gene3D; 3.30.1220.10; CobW-like, C-terminal domain; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 1.
DR InterPro; IPR036627; CobW-likC_sf.
DR InterPro; IPR011629; CobW-like_C.
DR InterPro; IPR003495; CobW/HypB/UreG_dom.
DR InterPro; IPR027417; P-loop_NTPase.
DR PANTHER; PTHR13748:SF62; COBW DOMAIN-CONTAINING PROTEIN; 1.
DR PANTHER; PTHR13748; COBW-RELATED; 1.
DR Pfam; PF02492; cobW; 1.
DR Pfam; PF07683; CobW_C; 1.
DR SMART; SM00833; CobW_C; 1.
DR SUPFAM; SSF90002; Hypothetical protein YjiA, C-terminal domain; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
PE 3: Inferred from homology;
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801}.
FT DOMAIN 281..375
FT /note="CobW C-terminal"
FT /evidence="ECO:0000259|SMART:SM00833"
FT REGION 236..278
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 238..278
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 376 AA; 41283 MW; 2D8996DFE74A4C97 CRC64;
MTDTLDAPVS TAAPQGSGGK IPVTVLTGYL GAGKTTLLNR ILTEDHGKRY AVIVNEFGEI
GIDNDLVVGA DEDVFEMNNG CVCCTVRGDL IRVVSGLMKR QRPGKPAFDA IIVETTGLAD
PGPVAQTFFV DEDVKAKTQL DSVTTLVDAK HVMARLDDSK EAREQVAFAD RIILNKVDLA
TPEEMEAVEA RLRALNPLAP IVRAERSNVP LDQVLGLGAF DLDRILEVKP DFVNPPHGAD
GHVHDEHCGH DHHHHDHDHD HDHHDHDHSH GARGHAHQDD IKGISLSLDR PLDGAKFTAW
LDRLLGEQGQ NILRAKGIID LKGEDRRLVF QAVHMILEGD LQREWGEGER RWSRAVFIGR
DLDEAELKAG FEACAA
//
