ID A0A0P0E6L6_9MICO Unreviewed; 568 AA.
AC A0A0P0E6L6;
DT 20-JAN-2016, integrated into UniProtKB/TrEMBL.
DT 20-JAN-2016, sequence version 1.
DT 27-MAR-2024, entry version 23.
DE SubName: Full=3'-5' exonuclease {ECO:0000313|EMBL:ALJ20467.1};
GN ORFNames=AOA12_11335 {ECO:0000313|EMBL:ALJ20467.1};
OS Microbacterium sp. No. 7.
OC Bacteria; Actinomycetota; Actinomycetes; Micrococcales; Microbacteriaceae;
OC Microbacterium.
OX NCBI_TaxID=1714373 {ECO:0000313|EMBL:ALJ20467.1, ECO:0000313|Proteomes:UP000059097};
RN [1] {ECO:0000313|EMBL:ALJ20467.1, ECO:0000313|Proteomes:UP000059097}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=No. 7 {ECO:0000313|EMBL:ALJ20467.1,
RC ECO:0000313|Proteomes:UP000059097};
RA Ohtsubo Y., Nagata Y., Numata M., Tsuchikane K., Hosoyama A., Yamazoe A.,
RA Tsuda M., Fujita N., Kawai F.;
RT "Complete genome sequence of a polypropylene glycol-degrading strain
RT Microbacterium sp. No. 7.";
RL Submitted (SEP-2015) to the EMBL/GenBank/DDBJ databases.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=a 2'-deoxyribonucleoside 5'-triphosphate + DNA(n) =
CC diphosphate + DNA(n+1); Xref=Rhea:RHEA:22508, Rhea:RHEA-COMP:17339,
CC Rhea:RHEA-COMP:17340, ChEBI:CHEBI:33019, ChEBI:CHEBI:61560,
CC ChEBI:CHEBI:173112; EC=2.7.7.7;
CC Evidence={ECO:0000256|ARBA:ARBA00024632};
CC -!- SIMILARITY: Belongs to the DNA polymerase type-A family.
CC {ECO:0000256|ARBA:ARBA00007705}.
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DR EMBL; CP012697; ALJ20467.1; -; Genomic_DNA.
DR RefSeq; WP_054682756.1; NZ_CP012697.1.
DR AlphaFoldDB; A0A0P0E6L6; -.
DR STRING; 1714373.AOA12_11335; -.
DR KEGG; mio:AOA12_11335; -.
DR PATRIC; fig|1714373.3.peg.2339; -.
DR OrthoDB; 4414061at2; -.
DR Proteomes; UP000059097; Chromosome.
DR GO; GO:0003677; F:DNA binding; IEA:InterPro.
DR GO; GO:0003887; F:DNA-directed DNA polymerase activity; IEA:InterPro.
DR GO; GO:0004527; F:exonuclease activity; IEA:UniProtKB-KW.
DR GO; GO:0006261; P:DNA-templated DNA replication; IEA:InterPro.
DR CDD; cd06444; DNA_pol_A; 1.
DR Gene3D; 3.30.70.370; -; 1.
DR Gene3D; 1.10.150.20; 5' to 3' exonuclease, C-terminal subdomain; 1.
DR InterPro; IPR001098; DNA-dir_DNA_pol_A_palm_dom.
DR InterPro; IPR043502; DNA/RNA_pol_sf.
DR InterPro; IPR002298; DNA_polymerase_A.
DR PANTHER; PTHR10133; DNA POLYMERASE I; 1.
DR PANTHER; PTHR10133:SF62; DNA POLYMERASE THETA; 1.
DR Pfam; PF00476; DNA_pol_A; 1.
DR SMART; SM00482; POLAc; 1.
DR SUPFAM; SSF56672; DNA/RNA polymerases; 1.
PE 3: Inferred from homology;
KW Exonuclease {ECO:0000313|EMBL:ALJ20467.1};
KW Hydrolase {ECO:0000313|EMBL:ALJ20467.1};
KW Nuclease {ECO:0000313|EMBL:ALJ20467.1};
KW Reference proteome {ECO:0000313|Proteomes:UP000059097}.
FT DOMAIN 305..525
FT /note="DNA-directed DNA polymerase family A palm"
FT /evidence="ECO:0000259|SMART:SM00482"
SQ SEQUENCE 568 AA; 60476 MW; DDF91FD6E501B506 CRC64;
MSAPPWTIVA RDDDGAVLVT VDGRGAEQAR RRVALAELPS ALGDDVRPVW NDTAQWYPAL
LDAGMTLARC RDLRLSHAIL RDSALVDAPP LRAATAWDAG PSTVSGAPSP ALFELDELAP
GIPDRVDEVL AEFARQQAAV DGSRDPGRLR LLLAAESAGA LVAAELHAAG VPWDRGVHEA
ILTDVLGGRP GPGSHAPRAE ELATRIRELL GDPQASLDSQ PKLLRALHRV GVLASSTSRW
ELAEHDHPVV APLLEYKRLT RLESANGWNW LDEWAGGGRF RPVYVPGGVV TGRWASSGGG
ALQLPRQLRP AVRADEGWLL VVADVAQLEP RVLAAMSGDL ALADAARGTD LYQGIVASGV
VGTRQEAKIA VLGAMYGGTT GDSGRLVPAL RRAYPRAMAL VDEAARVGEE GGVVSTWLGR
SAPPPPASWH RVQQRAADPD ADDADRARAV RAARDRGRFT RNFVVQGTAA EWALAWLADL
RGRLAALPVV PEDRRAPLSG VALGGRAHLA FFLHDEIVLH APEEQAELAA QAVRDAADAA
TRLLFGTFPV DFPLDLRISR DAGKALLE
//
