ID A0A0P0GNP2_9BACE Unreviewed; 1070 AA.
AC A0A0P0GNP2;
DT 20-JAN-2016, integrated into UniProtKB/TrEMBL.
DT 20-JAN-2016, sequence version 1.
DT 24-JAN-2024, entry version 39.
DE SubName: Full=Efflux RND transporter permease subunit {ECO:0000313|EMBL:KAA5411898.1};
DE SubName: Full=Efflux pump membrane transporter BepE {ECO:0000313|EMBL:ALJ59750.1};
GN Name=bepE_2 {ECO:0000313|EMBL:ALJ59750.1};
GN ORFNames=BcellWH2_02511 {ECO:0000313|EMBL:ALJ59750.1}, F2Y81_27690
GN {ECO:0000313|EMBL:KAA5411898.1};
OS Bacteroides cellulosilyticus.
OC Bacteria; Bacteroidota; Bacteroidia; Bacteroidales; Bacteroidaceae;
OC Bacteroides.
OX NCBI_TaxID=246787 {ECO:0000313|EMBL:ALJ59750.1, ECO:0000313|Proteomes:UP000061809};
RN [1] {ECO:0000313|EMBL:ALJ59750.1, ECO:0000313|Proteomes:UP000061809}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=WH2 {ECO:0000313|EMBL:ALJ59750.1,
RC ECO:0000313|Proteomes:UP000061809};
RX PubMed=26430127;
RA Wu M., McNulty N.P., Rodionov D.A., Khoroshkin M.S., Griffin N.W.,
RA Cheng J., Latreille P., Kerstetter R.A., Terrapon N., Henrissat B.,
RA Osterman A.L., Gordon J.I.;
RT "Genetic determinants of in vivo fitness and diet responsiveness in
RT multiple human gut Bacteroides.";
RL Science 350:AAC5992-AAC5992(2015).
RN [2] {ECO:0000313|EMBL:KAA5411898.1, ECO:0000313|Proteomes:UP000448877}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=BIOML-A6 {ECO:0000313|EMBL:KAA5411898.1,
RC ECO:0000313|Proteomes:UP000448877};
RX PubMed=31477907; DOI=.1038/s41591-019-0559-3;
RA Poyet M., Groussin M., Gibbons S.M., Avila-Pacheco J., Jiang X.,
RA Kearney S.M., Perrotta A.R., Berdy B., Zhao S., Lieberman T.D.,
RA Swanson P.K., Smith M., Roesemann S., Alexander J.E., Rich S.A., Livny J.,
RA Vlamakis H., Clish C., Bullock K., Deik A., Scott J., Pierce K.A.,
RA Xavier R.J., Alm E.J.;
RT "A library of human gut bacterial isolates paired with longitudinal
RT multiomics data enables mechanistic microbiome research.";
RL Nat. Med. 25:1442-1452(2019).
CC -!- SUBCELLULAR LOCATION: Cell inner membrane
CC {ECO:0000256|ARBA:ARBA00004429}; Multi-pass membrane protein
CC {ECO:0000256|ARBA:ARBA00004429}. Membrane
CC {ECO:0000256|ARBA:ARBA00004141}; Multi-pass membrane protein
CC {ECO:0000256|ARBA:ARBA00004141}.
CC -!- SIMILARITY: Belongs to the resistance-nodulation-cell division (RND)
CC (TC 2.A.6) family. {ECO:0000256|ARBA:ARBA00010942}.
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DR EMBL; CP012801; ALJ59750.1; -; Genomic_DNA.
DR EMBL; VVYV01000090; KAA5411898.1; -; Genomic_DNA.
DR RefSeq; WP_029426171.1; NZ_VVYV01000090.1.
DR AlphaFoldDB; A0A0P0GNP2; -.
DR STRING; 246787.BcellWH2_02511; -.
DR GeneID; 66306133; -.
DR KEGG; bcel:BcellWH2_02511; -.
DR PATRIC; fig|246787.4.peg.2585; -.
DR eggNOG; COG0841; Bacteria.
DR Proteomes; UP000061809; Chromosome.
DR Proteomes; UP000448877; Unassembled WGS sequence.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0015562; F:efflux transmembrane transporter activity; IEA:InterPro.
DR GO; GO:0042908; P:xenobiotic transport; IEA:InterPro.
DR Gene3D; 3.30.70.1430; Multidrug efflux transporter AcrB pore domain; 2.
DR Gene3D; 3.30.70.1440; Multidrug efflux transporter AcrB pore domain; 1.
DR Gene3D; 3.30.70.1320; Multidrug efflux transporter AcrB pore domain like; 1.
DR Gene3D; 1.20.1640.10; Multidrug efflux transporter AcrB transmembrane domain; 2.
DR InterPro; IPR027463; AcrB_DN_DC_subdom.
DR InterPro; IPR001036; Acrflvin-R.
DR InterPro; IPR004764; MdtF-like.
DR NCBIfam; TIGR00915; 2A0602; 1.
DR PANTHER; PTHR32063; -; 1.
DR PANTHER; PTHR32063:SF9; SIMILAR TO MULTIDRUG RESISTANCE PROTEIN MEXB; 1.
DR Pfam; PF00873; ACR_tran; 1.
DR PRINTS; PR00702; ACRIFLAVINRP.
DR SUPFAM; SSF82866; Multidrug efflux transporter AcrB transmembrane domain; 2.
PE 3: Inferred from homology;
KW Membrane {ECO:0000256|SAM:Phobius};
KW Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT TRANSMEM 12..33
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 338..357
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 364..384
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 390..415
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 436..456
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 468..495
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 539..556
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 869..887
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 894..918
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 938..963
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 984..1007
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 1019..1041
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
SQ SEQUENCE 1070 AA; 116537 MW; 932EF56922A7536A CRC64;
MKLDRFINRP VLSTVISVLI VILGLIGLAT LPITQYPDIA PPTVSVRATY TGANAQTVLN
SVIAPLEDQI NGVENMMYMT SNATNSGSAD ISVYFKQGTN PDMAAVNVQN RVSMAQGLLP
AEVTKVGVTT QKRQTSMLMV FSIYDETDQY NIEFLENYAN INLIPEVKRV AGVGDAMVLG
TDYSMRIWLK PDVMAQYKLI PNDVAAALAE QNIEAAPGQF GERGNQTFQY TIRYKGRLQQ
SEEFENIVIK AMENGEVLRL KDIADIELGR LTYSFNNTVN GHKAVSCIVF QMAGSNATQT
ISDLETLLND YSDKLPAGLH INIAQSANDF LFASIHEVIK TLIEAFILVF IVVYVFLQDF
RSTLIPAIAI PVALIATFFV LKLIGFSINL LTLSAMVLAI AIVVDDAIVV VEGVHAKLDQ
GYKSARAASI DAMSELGGAI VSITLVMMSV FIPVSFMGGT AGIFYRQFGL TMAIAIGFSA
LNALTLSPAL CAIFLKPHDE HGEKKSTFIS RFHTGFNVAY DKMLKKYKNN VLFFIQKKWL
SFGLVAGSIV LLIFFMKITP TGMVPNEDTG TIMGVVTLPP GTSQERAQEV LNRVDSLVAA
EPAVASRTVI SGYSFIGGQG PSYGSIIIKL KNWDERSTMQ NSNIVYITLF MRAQKIIKEA
QVLFFAPPMI SGYSASSDIE LNMQDKTGGD LNHFFDVVKS YNAALEARPE INSAKTTFNP
SFPQYMLDID AAACKKAGIS PSDILSTMQG YFGGLYASNF NSFGKMYRVM VQAEPEATKN
LESLSSIKVR NGDEMAPITQ FVSIKKVYGP DIISRFNLYT SMKVMVAPAS GYTSGQALAA
IAEVAKENLP AGFAYELGGM AREEAETSGS TTGLIFVLCF VFVYLLLSAQ YESYILPLAV
LLSIPFGLLG SFLFVNGMSA IGNISILKMI MGSMSNDIYM QIALIMLMGL LAKNAILIIE
FALDRRKMGM SITWAAVLGA AARLRPILMT SLAMIVGLIP LMMASGAGAN GNRTLGTSAI
GGMLIGMILQ IFIVPALFVA FQYLQEKIKP MEWTDVDNSD AEPEIEQYTK
//
