ID A0A0P0GSY5_9BACE Unreviewed; 494 AA.
AC A0A0P0GSY5;
DT 20-JAN-2016, integrated into UniProtKB/TrEMBL.
DT 20-JAN-2016, sequence version 1.
DT 24-JAN-2024, entry version 32.
DE SubName: Full=O-Antigen ligase {ECO:0000313|EMBL:ALJ61293.1};
GN ORFNames=BcellWH2_04073 {ECO:0000313|EMBL:ALJ61293.1}, F2Y81_20105
GN {ECO:0000313|EMBL:KAA5414558.1};
OS Bacteroides cellulosilyticus.
OC Bacteria; Bacteroidota; Bacteroidia; Bacteroidales; Bacteroidaceae;
OC Bacteroides.
OX NCBI_TaxID=246787 {ECO:0000313|EMBL:ALJ61293.1, ECO:0000313|Proteomes:UP000061809};
RN [1] {ECO:0000313|EMBL:ALJ61293.1, ECO:0000313|Proteomes:UP000061809}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=WH2 {ECO:0000313|EMBL:ALJ61293.1,
RC ECO:0000313|Proteomes:UP000061809};
RX PubMed=26430127;
RA Wu M., McNulty N.P., Rodionov D.A., Khoroshkin M.S., Griffin N.W.,
RA Cheng J., Latreille P., Kerstetter R.A., Terrapon N., Henrissat B.,
RA Osterman A.L., Gordon J.I.;
RT "Genetic determinants of in vivo fitness and diet responsiveness in
RT multiple human gut Bacteroides.";
RL Science 350:AAC5992-AAC5992(2015).
RN [2] {ECO:0000313|EMBL:KAA5414558.1, ECO:0000313|Proteomes:UP000448877}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=BIOML-A6 {ECO:0000313|EMBL:KAA5414558.1,
RC ECO:0000313|Proteomes:UP000448877};
RX PubMed=31477907; DOI=.1038/s41591-019-0559-3;
RA Poyet M., Groussin M., Gibbons S.M., Avila-Pacheco J., Jiang X.,
RA Kearney S.M., Perrotta A.R., Berdy B., Zhao S., Lieberman T.D.,
RA Swanson P.K., Smith M., Roesemann S., Alexander J.E., Rich S.A., Livny J.,
RA Vlamakis H., Clish C., Bullock K., Deik A., Scott J., Pierce K.A.,
RA Xavier R.J., Alm E.J.;
RT "A library of human gut bacterial isolates paired with longitudinal
RT multiomics data enables mechanistic microbiome research.";
RL Nat. Med. 25:1442-1452(2019).
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
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DR EMBL; CP012801; ALJ61293.1; -; Genomic_DNA.
DR EMBL; VVYV01000040; KAA5414558.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A0P0GSY5; -.
DR STRING; 246787.BcellWH2_04073; -.
DR KEGG; bcel:BcellWH2_04073; -.
DR PATRIC; fig|246787.4.peg.4213; -.
DR eggNOG; COG3307; Bacteria.
DR Proteomes; UP000061809; Chromosome.
DR Proteomes; UP000448877; Unassembled WGS sequence.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0016874; F:ligase activity; IEA:UniProtKB-KW.
DR Gene3D; 1.25.40.10; Tetratricopeptide repeat domain; 1.
DR InterPro; IPR007016; O-antigen_ligase-related.
DR InterPro; IPR011990; TPR-like_helical_dom_sf.
DR PANTHER; PTHR37422:SF18; O-ANTIGEN LIGASE; 1.
DR PANTHER; PTHR37422; TEICHURONIC ACID BIOSYNTHESIS PROTEIN TUAE; 1.
DR Pfam; PF04932; Wzy_C; 1.
DR SUPFAM; SSF48452; TPR-like; 1.
PE 4: Predicted;
KW Ligase {ECO:0000313|EMBL:ALJ61293.1};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}.
FT TRANSMEM 12..30
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 42..58
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 67..87
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 107..126
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 133..151
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 157..173
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 180..199
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 272..290
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 302..331
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 343..362
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
SQ SEQUENCE 494 AA; 57370 MW; 5640962D180AE6EE CRC64;
MRQYRIKYVC TLYDILVLCF ILWWISSSFI FNSRVISNEQ LIYSYTLSVV YVATRIFRSS
ISVQRRLYIC IAFLGSIEAI IGWGQYWNII ESNHPLFSIT GTFTNPGPYG AFLGIALLIQ
IHFAWHKYIA KQYMSLFMLL IVGLLTGSMF IASFSRAAWV ALLIAVSFFF FLFQKKRYRY
AGLLLLILFL FSSPFLYQLK KQSADGRLFI WRVCTELIQS KPYTGGGASS FAARYMYAQA
DFLEKHPNHE YAAKATNNIY AFNEYLRIAC EYGLPGILLY VTIWLHGIYC KATYCDRLRK
LLLIYLAVFS LFSYTFQVLP LAVLCIVLGA FQNNNSKFTF YAFPMRYLVI MLLLMTIIAW
SGTRSSQYEK KEILFTAKQL YTQQNYADAK EYLEKAAYLS PTSEILMDLG NSYFHLQNNA
KAEHCFRIAC NMVPGRILPQ YYLFRFYAIT MRNQEAITLG QSILFGDYQL EGSIAMQAKT
HIKRYLSDIR MQTK
//
