ID A0A0P0ILR4_9ACTN Unreviewed; 335 AA.
AC A0A0P0ILR4;
DT 20-JAN-2016, integrated into UniProtKB/TrEMBL.
DT 20-JAN-2016, sequence version 1.
DT 27-MAR-2024, entry version 26.
DE SubName: Full=FlsM {ECO:0000313|EMBL:ALJ99866.1};
DE SubName: Full=Hydroxyneurosporene methyltransferase {ECO:0000313|EMBL:KXK58689.1};
GN ORFNames=AWW66_28350 {ECO:0000313|EMBL:KXK58689.1};
OS Micromonospora rosaria.
OC Bacteria; Actinomycetota; Actinomycetes; Micromonosporales;
OC Micromonosporaceae; Micromonospora.
OX NCBI_TaxID=47874 {ECO:0000313|EMBL:ALJ99866.1};
RN [1] {ECO:0000313|EMBL:ALJ99866.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=SCSIO N160 {ECO:0000313|EMBL:ALJ99866.1};
RX PubMed=26465097; DOI=10.1021/acs.orglett.5b02683;
RA Yang C., Huang C., Zhang W., Zhu Y., Zhang C.;
RT "Heterologous Expression of Fluostatin Gene Cluster Leads to a Bioactive
RT Heterodimer.";
RL Org. Lett. 17:5324-5327(2015).
RN [2] {ECO:0000313|EMBL:KXK58689.1, ECO:0000313|Proteomes:UP000070620}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=DSM 803 {ECO:0000313|EMBL:KXK58689.1,
RC ECO:0000313|Proteomes:UP000070620};
RA Yang H., He X., Zhu D.;
RT "Whole genome sequence and analysis of Micromonospora rosaria DSM 803,
RT which can produce antibacterial substance rosamicin.";
RL Submitted (JAN-2016) to the EMBL/GenBank/DDBJ databases.
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DR EMBL; KT726162; ALJ99866.1; -; Genomic_DNA.
DR EMBL; LRQV01000166; KXK58689.1; -; Genomic_DNA.
DR RefSeq; WP_067372646.1; NZ_LRQV01000166.1.
DR AlphaFoldDB; A0A0P0ILR4; -.
DR OrthoDB; 3804952at2; -.
DR Proteomes; UP000070620; Unassembled WGS sequence.
DR GO; GO:0008171; F:O-methyltransferase activity; IEA:InterPro.
DR GO; GO:0032259; P:methylation; IEA:UniProtKB-KW.
DR CDD; cd02440; AdoMet_MTases; 1.
DR Gene3D; 1.10.287.1350; -; 1.
DR Gene3D; 3.40.50.150; Vaccinia Virus protein VP39; 1.
DR Gene3D; 1.10.10.10; Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain; 1.
DR InterPro; IPR031725; ASMT_dimerisation.
DR InterPro; IPR016461; COMT-like.
DR InterPro; IPR001077; O_MeTrfase_dom.
DR InterPro; IPR029063; SAM-dependent_MTases_sf.
DR InterPro; IPR036388; WH-like_DNA-bd_sf.
DR InterPro; IPR036390; WH_DNA-bd_sf.
DR PANTHER; PTHR43712:SF2; O-METHYLTRANSFERASE CICE; 1.
DR PANTHER; PTHR43712; PUTATIVE (AFU_ORTHOLOGUE AFUA_4G14580)-RELATED; 1.
DR Pfam; PF16864; Dimerisation2; 1.
DR Pfam; PF00891; Methyltransf_2; 1.
DR PIRSF; PIRSF005739; O-mtase; 1.
DR SUPFAM; SSF53335; S-adenosyl-L-methionine-dependent methyltransferases; 1.
DR SUPFAM; SSF46785; Winged helix' DNA-binding domain; 1.
DR PROSITE; PS51683; SAM_OMT_II; 1.
PE 4: Predicted;
KW Methyltransferase {ECO:0000313|EMBL:KXK58689.1};
KW Reference proteome {ECO:0000313|Proteomes:UP000070620};
KW S-adenosyl-L-methionine {ECO:0000256|ARBA:ARBA00022691};
KW Transferase {ECO:0000313|EMBL:KXK58689.1}.
FT DOMAIN 10..85
FT /note="Acetylserotonin O-methyltransferase dimerisation"
FT /evidence="ECO:0000259|Pfam:PF16864"
FT DOMAIN 110..316
FT /note="O-methyltransferase"
FT /evidence="ECO:0000259|Pfam:PF00891"
FT ACT_SITE 245
FT /note="Proton acceptor"
FT /evidence="ECO:0000256|PIRSR:PIRSR005739-1"
SQ SEQUENCE 335 AA; 35907 MW; D8FDBA4799E84D36 CRC64;
MSSIPAPFAL LNLVQGAMVS QALYAAATLG IADELADGPL APEEIGKRVD ADPESTYRLL
RVLAAHGVFA ERQDKTFELT PMADALRTDA PLSMRRIARL MGHPTHWEDW GHFLEAVRTG
EPSLPKVRGM SAWEYFGANP EYAQVFFAGM GNLSDLETVP VSQGYDYSPF GRIVDVGGGS
GALLAAILER TPQASGVVFA PSSVEAAQQV LAQAGVADRC TIEEGSFLES APAGGDAYIL
KHIVHDWPHE QAVAILRNVR SVIGPKGKLL LMESVVPEGN TPHSSKLVDL WLLLLVGGRE
RTEAEYRRLL SDAGFALSKI TETPAGVAII EADPV
//