ID   A0A0P0N451_9CREN        Unreviewed;       339 AA.
AC   A0A0P0N451;
DT   20-JAN-2016, integrated into UniProtKB/TrEMBL.
DT   20-JAN-2016, sequence version 1.
DT   24-JAN-2024, entry version 28.
DE   RecName: Full=phosphoribosylformylglycinamidine cyclo-ligase {ECO:0000256|ARBA:ARBA00013047};
DE            EC=6.3.3.1 {ECO:0000256|ARBA:ARBA00013047};
GN   ORFNames=Pdsh_06230 {ECO:0000313|EMBL:OWJ54615.1}, Pyrde_1426
GN   {ECO:0000313|EMBL:ALL01470.1};
OS   Pyrodictium delaneyi.
OC   Archaea; Thermoproteota; Thermoprotei; Desulfurococcales; Pyrodictiaceae;
OC   Pyrodictium.
OX   NCBI_TaxID=1273541 {ECO:0000313|EMBL:ALL01470.1, ECO:0000313|Proteomes:UP000058613};
RN   [1] {ECO:0000313|EMBL:ALL01470.1, ECO:0000313|Proteomes:UP000058613}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Su06 {ECO:0000313|EMBL:ALL01470.1,
RC   ECO:0000313|Proteomes:UP000058613};
RA   Jung J.-H., Lin J., Holden J.F., Park C.-S.;
RT   "Complete genome sequence of hyperthermophilic archaeon Pyrodictium
RT   delaneyi Su06.";
RL   Submitted (OCT-2015) to the EMBL/GenBank/DDBJ databases.
RN   [2] {ECO:0000313|EMBL:OWJ54615.1, ECO:0000313|Proteomes:UP000196694}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Hulk {ECO:0000313|EMBL:OWJ54615.1,
RC   ECO:0000313|Proteomes:UP000196694};
RA   Demey L.M., Miller C., Manzella M., Reguera G., Kashefi K.;
RT   "The draft genome of the hyperthermophilic archaeon 'Pyrodictium delaneyi
RT   strain Hulk', an iron and nitrate reducer, reveals the capacity for sulfate
RT   reduction.";
RL   Submitted (MAY-2017) to the EMBL/GenBank/DDBJ databases.
CC   -!- PATHWAY: Purine metabolism; IMP biosynthesis via de novo pathway; 5-
CC       amino-1-(5-phospho-D-ribosyl)imidazole from N(2)-formyl-N(1)-(5-
CC       phospho-D-ribosyl)glycinamide: step 2/2.
CC       {ECO:0000256|ARBA:ARBA00004686}.
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DR   EMBL; CP013011; ALL01470.1; -; Genomic_DNA.
DR   EMBL; NCQP01000003; OWJ54615.1; -; Genomic_DNA.
DR   RefSeq; WP_055409483.1; NZ_NCQP01000003.1.
DR   AlphaFoldDB; A0A0P0N451; -.
DR   STRING; 1273541.Pyrde_1426; -.
DR   GeneID; 26099768; -.
DR   KEGG; pdl:Pyrde_1426; -.
DR   PATRIC; fig|1273541.4.peg.1522; -.
DR   OrthoDB; 6605at2157; -.
DR   UniPathway; UPA00074; UER00129.
DR   Proteomes; UP000058613; Chromosome.
DR   Proteomes; UP000196694; Unassembled WGS sequence.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR   GO; GO:0004641; F:phosphoribosylformylglycinamidine cyclo-ligase activity; IEA:UniProtKB-EC.
DR   GO; GO:0006189; P:'de novo' IMP biosynthetic process; IEA:UniProtKB-UniPathway.
DR   CDD; cd02196; PurM; 1.
DR   Gene3D; 3.90.650.10; PurM-like C-terminal domain; 1.
DR   Gene3D; 3.30.1330.10; PurM-like, N-terminal domain; 1.
DR   InterPro; IPR010918; PurM-like_C_dom.
DR   InterPro; IPR036676; PurM-like_C_sf.
DR   InterPro; IPR016188; PurM-like_N.
DR   InterPro; IPR036921; PurM-like_N_sf.
DR   InterPro; IPR004733; PurM_cligase.
DR   PANTHER; PTHR10520:SF12; TRIFUNCTIONAL PURINE BIOSYNTHETIC PROTEIN ADENOSINE-3; 1.
DR   PANTHER; PTHR10520; TRIFUNCTIONAL PURINE BIOSYNTHETIC PROTEIN ADENOSINE-3-RELATED; 1.
DR   Pfam; PF00586; AIRS; 1.
DR   Pfam; PF02769; AIRS_C; 1.
DR   SUPFAM; SSF56042; PurM C-terminal domain-like; 1.
DR   SUPFAM; SSF55326; PurM N-terminal domain-like; 1.
PE   4: Predicted;
KW   ATP-binding {ECO:0000256|ARBA:ARBA00022840};
KW   Ligase {ECO:0000256|ARBA:ARBA00022598, ECO:0000313|EMBL:ALL01470.1};
KW   Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741}.
FT   DOMAIN          50..152
FT                   /note="PurM-like N-terminal"
FT                   /evidence="ECO:0000259|Pfam:PF00586"
FT   DOMAIN          165..324
FT                   /note="PurM-like C-terminal"
FT                   /evidence="ECO:0000259|Pfam:PF02769"
SQ   SEQUENCE   339 AA;  36268 MW;  66EA78E7D12F9134 CRC64;
     MARNRSTAET SLSYRDAGVD LDASEALHTL ASRLLAGRRE AYTSSVELAG LELILHVDGV
     GTKTLVLEKL GRLRVAGWDC VVMNTNDVAC DAARPLALVD YIAMPRADEA IFREILEGIR
     EAAAATGAVL LGGETAILPG LAQGVDVVCT ILAVREPGWR GNRARPGDVL VGLESSGLHA
     NGYSLARRII EERLGGYTAE IEGLDLAEEL SKPVKDYTGF LLEAWSQGLV IAAAHITGGA
     FTKMKRILPS GATAVMKMPK PPRIFQVLME AGNVEPSEAY RVWNMGIGLV VAAPRESVDE
     LLDLAEKHGH KPHVLGLIEQ GRDGARILLD TPYGKVAYS
//