ID A0A0P0QKN7_9VIRU Unreviewed; 808 AA.
AC A0A0P0QKN7;
DT 20-JAN-2016, integrated into UniProtKB/TrEMBL.
DT 20-JAN-2016, sequence version 1.
DT 27-MAR-2024, entry version 45.
DE SubName: Full=NS3-like protein {ECO:0000313|EMBL:ALL52901.1};
OS Wuhan aphid virus 1.
OC Viruses; Riboviria.
OX NCBI_TaxID=1746067 {ECO:0000313|EMBL:ALL52901.1, ECO:0000313|Proteomes:UP000203860};
RN [1] {ECO:0000313|EMBL:ALL52901.1, ECO:0000313|Proteomes:UP000203860}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=WHYC-1 {ECO:0000313|EMBL:ALL52901.1,
RC ECO:0000313|Proteomes:UP000203860};
RX PubMed=26491167; DOI=10.1128/JVI.02036-15;
RA Shi M., Lin X.D., Vasilakis N., Tian J.H., Li C.X., Chen L.J., Eastwood G.,
RA Diao X.N., Chen M.H., Chen X., Qin X.C., Widen S.G., Wood T.G., Tesh R.B.,
RA Xu J., Holmes E.C., Zhang Y.Z.;
RT "Divergent Viruses Discovered in Arthropods and Vertebrates Revise the
RT Evolutionary History of the Flaviviridae and Related Viruses.";
RL J. Virol. 90:659-669(2015).
CC -!- CATALYTIC ACTIVITY:
CC Reaction=ATP + H2O = ADP + H(+) + phosphate; Xref=Rhea:RHEA:13065,
CC ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:30616,
CC ChEBI:CHEBI:43474, ChEBI:CHEBI:456216; EC=3.6.4.13;
CC Evidence={ECO:0000256|ARBA:ARBA00001556};
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DR EMBL; KR902723; ALL52901.1; -; Genomic_RNA.
DR RefSeq; YP_009179389.1; NC_028389.1.
DR GeneID; 26196673; -.
DR KEGG; vg:26196673; -.
DR OrthoDB; 5539at10239; -.
DR Proteomes; UP000203860; Genome.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR GO; GO:0019028; C:viral capsid; IEA:UniProtKB-KW.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0004386; F:helicase activity; IEA:InterPro.
DR GO; GO:0016787; F:hydrolase activity; IEA:UniProtKB-KW.
DR Gene3D; 2.40.10.120; -; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 2.
DR InterPro; IPR011492; Flavi_DEAD.
DR InterPro; IPR014001; Helicase_ATP-bd.
DR InterPro; IPR001650; Helicase_C.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR009003; Peptidase_S1_PA.
DR PANTHER; PTHR18934; ATP-DEPENDENT RNA HELICASE; 1.
DR PANTHER; PTHR18934:SF83; PRE-MRNA-SPLICING FACTOR ATP-DEPENDENT RNA HELICASE DHX16; 1.
DR Pfam; PF07652; Flavi_DEAD; 1.
DR Pfam; PF00271; Helicase_C; 1.
DR SMART; SM00487; DEXDc; 1.
DR SMART; SM00490; HELICc; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR SUPFAM; SSF50494; Trypsin-like serine proteases; 1.
DR PROSITE; PS51192; HELICASE_ATP_BIND_1; 1.
DR PROSITE; PS51194; HELICASE_CTER; 1.
PE 4: Predicted;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840};
KW Capsid protein {ECO:0000256|ARBA:ARBA00022561};
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801};
KW Membrane {ECO:0000256|SAM:Phobius};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022840};
KW Reference proteome {ECO:0000313|Proteomes:UP000203860};
KW Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius};
KW Virion {ECO:0000256|ARBA:ARBA00022561}.
FT TRANSMEM 12..28
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 58..82
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 196..222
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 398..557
FT /note="Helicase ATP-binding"
FT /evidence="ECO:0000259|PROSITE:PS51192"
FT DOMAIN 564..717
FT /note="Helicase C-terminal"
FT /evidence="ECO:0000259|PROSITE:PS51194"
SQ SEQUENCE 808 AA; 91584 MW; FC5CA579659DBCB5 CRC64;
MITIASHNPT ALPHFWLIVL SLLMFSFFEI NDLKLPALVI VWYFDQGLRL FGKSDVKYFW
YVASLYCIFS RTSFMIPCFM ILCQTIAHER TRDILRFVET SILNVCYYLK DIAIPYARPW
MGDNSLPFIQ PYLDDLQTAY ESFLIEMQWT ITSTAEFLRS EGVSTAPLDM RDHAPMGADT
ALLTYQKYSK MAKTSAMFLT TVALVLMLGP VGICVTLVTY LATLTETDET YTKIDETSKG
MKFPSGTYRI RNSLLGFILE TGIGVGYNGI LHVPYHVCRG LPINYGKGVI KPYYVSISED
ICTYGGPPQF TTPDTTGEIY VNCETDQSRT TYRVDVDISD SASLLSWPGL TKPGESGSPV
YMIRGEKTYL LALAGRYIKD MNSNTTEFAR TTICEDSDLE EFDHNVKQVI THPGSGKTRV
MIPNIIMHEL PAMKGKTILI TGPTRVVCRE MHGSLKNKFK VGLNIKGQKH ERDPLAYVQI
AAHRTALRML LTGDRILRNL GMVMIDEAHV DDPATMLLRQ YARHLSERGV KVVELSATLD
DRSDNGSNFT IQDKEIKADD IIPCIQKALD EEKRVMVFVP SFSDRNTQQI MKHFKTYEPI
ELSRRNFENA ATAVADVNRR LILSTDIAEC GINVPDLDVV VDTGLKYTYS EECGIISGRK
IGLTQASIVQ RRGRVGRSKP GSYFFVDVPR QAQIKTAAQV DSELLATGRN WAMKGGNPWN
KMLTDKQFMT WLESDKPPLE IYLTTDYMGM QKNIPDLRRD IQKWRNGKNG TYYKGCSNSC
DKCQGHYEFY DERMHDTVFQ VKTHVELT
//
