ID A0A0P0SD59_9PSEU Unreviewed; 325 AA.
AC A0A0P0SD59;
DT 20-JAN-2016, integrated into UniProtKB/TrEMBL.
DT 20-JAN-2016, sequence version 1.
DT 27-MAR-2024, entry version 29.
DE SubName: Full=RNA methyltransferase {ECO:0000313|EMBL:ALL82173.1};
GN ORFNames=AD017_15085 {ECO:0000313|EMBL:ALL82173.1};
OS Pseudonocardia sp. EC080619-01.
OC Bacteria; Actinomycetota; Actinomycetes; Pseudonocardiales;
OC Pseudonocardiaceae; Pseudonocardia.
OX NCBI_TaxID=1096856 {ECO:0000313|EMBL:ALL82173.1, ECO:0000313|Proteomes:UP000066228};
RN [1] {ECO:0000313|EMBL:ALL82173.1, ECO:0000313|Proteomes:UP000066228}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=EC080619-01 {ECO:0000313|EMBL:ALL82173.1,
RC ECO:0000313|Proteomes:UP000066228};
RX PubMed=26535611; DOI=10.1021/jacs.5b09794;
RA Van Arnam E.B., Sit C.S.;
RT "A Rebeccamycin Analog Provides Plasmid-Encoded Niche Defense.";
RL J. Am. Chem. Soc. 137:14272-14274(2015).
CC -!- SIMILARITY: Belongs to the class IV-like SAM-binding methyltransferase
CC superfamily. RNA methyltransferase TrmH family.
CC {ECO:0000256|ARBA:ARBA00007228}.
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DR EMBL; CP012184; ALL82173.1; -; Genomic_DNA.
DR RefSeq; WP_060574608.1; NZ_CP012184.1.
DR AlphaFoldDB; A0A0P0SD59; -.
DR STRING; 1096856.AD017_15085; -.
DR KEGG; pecq:AD017_15085; -.
DR PATRIC; fig|1096856.3.peg.3164; -.
DR OrthoDB; 9785673at2; -.
DR Proteomes; UP000066228; Chromosome.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProt.
DR GO; GO:0003723; F:RNA binding; IEA:InterPro.
DR GO; GO:0008173; F:RNA methyltransferase activity; IEA:InterPro.
DR GO; GO:0032259; P:methylation; IEA:UniProtKB-KW.
DR GO; GO:0006396; P:RNA processing; IEA:InterPro.
DR CDD; cd18103; SpoU-like_RlmB; 1.
DR Gene3D; 3.30.1330.30; -; 1.
DR Gene3D; 3.40.1280.10; -; 1.
DR InterPro; IPR029028; Alpha/beta_knot_MTases.
DR InterPro; IPR029064; Ribosomal_eL30-like_sf.
DR InterPro; IPR004441; rRNA_MeTrfase_TrmH.
DR InterPro; IPR001537; SpoU_MeTrfase.
DR InterPro; IPR013123; SpoU_subst-bd.
DR InterPro; IPR029026; tRNA_m1G_MTases_N.
DR NCBIfam; TIGR00186; rRNA_methyl_3; 1.
DR PANTHER; PTHR46429; 23S RRNA (GUANOSINE-2'-O-)-METHYLTRANSFERASE RLMB; 1.
DR PANTHER; PTHR46429:SF1; 23S RRNA (GUANOSINE-2'-O-)-METHYLTRANSFERASE RLMB; 1.
DR Pfam; PF00588; SpoU_methylase; 1.
DR Pfam; PF08032; SpoU_sub_bind; 1.
DR SMART; SM00967; SpoU_sub_bind; 1.
DR SUPFAM; SSF75217; alpha/beta knot; 1.
DR SUPFAM; SSF55315; L30e-like; 1.
PE 3: Inferred from homology;
KW Methyltransferase {ECO:0000313|EMBL:ALL82173.1};
KW Reference proteome {ECO:0000313|Proteomes:UP000066228};
KW Transferase {ECO:0000313|EMBL:ALL82173.1}.
FT DOMAIN 81..157
FT /note="RNA 2-O ribose methyltransferase substrate binding"
FT /evidence="ECO:0000259|SMART:SM00967"
FT REGION 1..84
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 48..74
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 325 AA; 33928 MW; AED2ACF97621866C CRC64;
MAGNSKRRGA VRKEGTKKGP VIGSGGQPRR SLRGKGPTPS GEMRPGHPKQ KAAARRDRQD
QQQQRRRPVA GRRGDGEGPE TVLGRNPVVE CLRAGVPSTA LHVATGMSAD ERVAEAVSLA
AEQGISILEV PRNDLDRLTG GALHQGLALQ VPPYSYAHPD ELLEAAADSG RPALTVALDG
VTDPRNLGAV VRSVGAFGGH GVVVPQRRAA GMTAVAWRTS AGTAVRVPVA RATNLTRTLR
EYASAGLMVV GLAADGDVSL DEFDLATGPL ALVTGSEGKG LSRLVRETCD LTVSIPLAGR
VESLNASVAT GVVLAEVARR RRLER
//
