ID A0A0P1A659_PLAHL Unreviewed; 1675 AA.
AC A0A0P1A659;
DT 20-JAN-2016, integrated into UniProtKB/TrEMBL.
DT 20-JAN-2016, sequence version 1.
DT 27-MAR-2024, entry version 38.
DE SubName: Full=Ras-specific guanine nucleotide-releasing {ECO:0000313|EMBL:CEG36058.1};
OS Plasmopara halstedii (Downy mildew of sunflower).
OC Eukaryota; Sar; Stramenopiles; Oomycota; Peronosporales; Peronosporaceae;
OC Plasmopara.
OX NCBI_TaxID=4781 {ECO:0000313|EMBL:CEG36058.1, ECO:0000313|Proteomes:UP000054928};
RN [1] {ECO:0000313|Proteomes:UP000054928}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Sharma Rahul, Thines Marco;
RL Submitted (SEP-2014) to the EMBL/GenBank/DDBJ databases.
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DR EMBL; CCYD01000109; CEG36058.1; -; Genomic_DNA.
DR STRING; 4781.A0A0P1A659; -.
DR EnsemblProtists; CEG36058; CEG36058; CEG36058.
DR OMA; APCALID; -.
DR OrthoDB; 48396at2759; -.
DR Proteomes; UP000054928; Unassembled WGS sequence.
DR GO; GO:0005085; F:guanyl-nucleotide exchange factor activity; IEA:UniProtKB-KW.
DR GO; GO:0007264; P:small GTPase mediated signal transduction; IEA:InterPro.
DR Gene3D; 1.25.40.20; Ankyrin repeat-containing domain; 4.
DR Gene3D; 2.30.29.30; Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB); 1.
DR Gene3D; 1.10.840.10; Ras guanine-nucleotide exchange factors catalytic domain; 1.
DR Gene3D; 1.20.1050.80; VPS9 domain; 1.
DR InterPro; IPR002110; Ankyrin_rpt.
DR InterPro; IPR036770; Ankyrin_rpt-contain_sf.
DR InterPro; IPR011993; PH-like_dom_sf.
DR InterPro; IPR001849; PH_domain.
DR InterPro; IPR019804; Ras_G-nucl-exch_fac_CS.
DR InterPro; IPR023578; Ras_GEF_dom_sf.
DR InterPro; IPR001895; RASGEF_cat_dom.
DR InterPro; IPR036964; RASGEF_cat_dom_sf.
DR InterPro; IPR003123; VPS9.
DR InterPro; IPR037191; VPS9_dom_sf.
DR PANTHER; PTHR24173; ANKYRIN REPEAT CONTAINING; 1.
DR PANTHER; PTHR24173:SF74; UVEAL AUTOANTIGEN WITH COILED-COIL DOMAINS AND ANKYRIN REPEATS; 1.
DR Pfam; PF00023; Ank; 1.
DR Pfam; PF12796; Ank_2; 2.
DR Pfam; PF13637; Ank_4; 1.
DR Pfam; PF00169; PH; 1.
DR Pfam; PF00617; RasGEF; 1.
DR Pfam; PF02204; VPS9; 1.
DR SMART; SM00248; ANK; 7.
DR SMART; SM00233; PH; 1.
DR SMART; SM00147; RasGEF; 1.
DR SUPFAM; SSF48403; Ankyrin repeat; 1.
DR SUPFAM; SSF50729; PH domain-like; 1.
DR SUPFAM; SSF48366; Ras GEF; 1.
DR SUPFAM; SSF109993; VPS9 domain; 1.
DR PROSITE; PS50297; ANK_REP_REGION; 3.
DR PROSITE; PS50088; ANK_REPEAT; 3.
DR PROSITE; PS50003; PH_DOMAIN; 1.
DR PROSITE; PS00720; RASGEF; 1.
DR PROSITE; PS50009; RASGEF_CAT; 1.
DR PROSITE; PS51205; VPS9; 1.
PE 4: Predicted;
KW ANK repeat {ECO:0000256|PROSITE-ProRule:PRU00023};
KW Guanine-nucleotide releasing factor {ECO:0000256|PROSITE-ProRule:PRU00168};
KW Reference proteome {ECO:0000313|Proteomes:UP000054928};
KW Repeat {ECO:0000256|ARBA:ARBA00022737}.
FT DOMAIN 221..329
FT /note="PH"
FT /evidence="ECO:0000259|PROSITE:PS50003"
FT DOMAIN 488..634
FT /note="VPS9"
FT /evidence="ECO:0000259|PROSITE:PS51205"
FT REPEAT 771..803
FT /note="ANK"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00023"
FT REPEAT 901..933
FT /note="ANK"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00023"
FT REPEAT 934..966
FT /note="ANK"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00023"
FT DOMAIN 1423..1644
FT /note="Ras-GEF"
FT /evidence="ECO:0000259|PROSITE:PS50009"
FT REGION 22..80
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 29..49
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 50..66
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1675 AA; 185904 MW; 1A03BB2CFD455BB2 CRC64;
MDRSTISLHR VPSDVLKRDL ERKGGIASPG QLNFSTFLMD EGSSPLQPQN GTKRPPPPPL
PPLRAQSASH TPPRRKNVPR LIAGYRGGSD VDIPVLEAAR ESSGFRLDGP DQVEVEVNCD
GEGGAEAKVV VGDYDAEEDD YVPVLQTAED AQRAHRHMGS KKFSWRASAK RGVPLNKAVR
VPDQETLLSM STRGADVMSN YSSNNLHGLR RNSSSVRIDR ELVRSGWLYK QANVMKTWKR
RYFVLIKRTN LATGEYWASL QYYKGSNFGK LRGEMHLQDG MLSVRFLEPD ETKRPFCFEV
AGEDFSFVCS GSNDDDASAW VCLLQSLSGG GNSTISPSAA LLSSVSNSKL QHVDGLSSVR
LRTSTIDARS IRIVAELRRV LHTSKSPEAV TFKSFISSFD CRNPGALREL NEFNLKLTDS
IVKDHGARIL AALKDPRNDD VNGIVKATEK NLPISLDILR SAVFRHVEEV LFVPLQSKIN
SLLRRVYHEE ESSINRKVRW LQGKDQMYFN IPPHQVSWKE WRKASRILAQ IAQVQLPAAK
YDVLTSTMKE IQASYAEEHG TIDNLERLEP DDIIPIFTYV LSNSGLENLI SLKTLLTELN
GSLSGGGSSD DETSLSILTH AVDFISNVSI PAVLEDIFKD QITLSIDGDW RRVLEFELES
TYRYGAVVDH ISPQGFSAVG NIITRGFVLV TVNGQNVVLW PFQDIMTLLL ESASPHRLAF
IPGSSYFKIL TSNKALWNVA LMHACQRGDV FSVQMLLANG ADVNYVAYEC GSNTPLHVAV
SALHLNVVSY VLQHGAKVKT TGEFRRSALH MAGSPCMMPA IGNTSQDMTK SVTVTSVTLS
NADKAALIVK KLIDHGATMD CVDIYGNTPI MLLAERGYLG AIDAIMEADC NVDLNARNWQ
RGMSALALAA RSGQADVVEG LLNYKAQADI RTLRGETPLH FAAASASQRA CQLLVEKSCN
VDARTSEGLT PLMIAVAKDY DMVTDTSFLP SLSCQLADNY YDSQMYQQST INLRGSTPVN
NSSTLSTITY LIQSGADTSA VCNVYRTPLH YAALYGCDEI FACLLAKLGD NTKADRCDLY
GQSAVFMSEA IRSSGANANE ILSGGNSTTT IEEFCGVGEN DDDDSDDEFL DVEHAAIPMS
LTGRKDLVGL TSNRKDLVIE YNNGVEEVVA GTFDAIADLL MRYKNYRLEE LSALIWSCAY
ASDGGGDKFR EMVDILRSLW RQHSMGTDTG IFVRRMVLSA LNKLVEILKH SVECDLLVCN
YVAELCMEVI PLNTETVEED PQCAQWISTS LLPEFTDACQ SNRVQEFQIL SFCEGDYKSL
KHFICKAKQA NPNLDFLDDD LFAAATGMEI ITEGMRRRMS LAGVWKTGEA KNSFVVKPED
NLETLEETRS TTITPWQPRG VSVGRTFATE QHRMARLWIL DIDPSIIAQQ ITLLQHYLFS
KIKVSEVLAS KRNAEKTPGY QRLRLLHNHI SIWVVNQVLM RGDVDQRAEI LAYFIRVAGV
LLSPLQNIDG FMAVMNAAND SSVFRLKKTW GRLSPQVRDL WQELVPLTEK GARSLNKFTK
EANPPLIPYI GVVIQNVLAL QEYPDRVEGD LINFKKIRSI GILIQRMLSY QKTPYLLPTD
KRVLEQICST VAFSDGESMI LLYLLVESLL ATHDVYLCKF GANFITAITP DMYNF
//
