ID A0A0P1A797_PLAHL Unreviewed; 4602 AA.
AC A0A0P1A797;
DT 20-JAN-2016, integrated into UniProtKB/TrEMBL.
DT 20-JAN-2016, sequence version 1.
DT 27-MAR-2024, entry version 38.
DE SubName: Full=Hect e3 ubiquitin {ECO:0000313|EMBL:CEG36120.1};
OS Plasmopara halstedii (Downy mildew of sunflower).
OC Eukaryota; Sar; Stramenopiles; Oomycota; Peronosporales; Peronosporaceae;
OC Plasmopara.
OX NCBI_TaxID=4781 {ECO:0000313|EMBL:CEG36120.1, ECO:0000313|Proteomes:UP000054928};
RN [1] {ECO:0000313|Proteomes:UP000054928}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Sharma Rahul, Thines Marco;
RL Submitted (SEP-2014) to the EMBL/GenBank/DDBJ databases.
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DR EMBL; CCYD01000109; CEG36120.1; -; Genomic_DNA.
DR STRING; 4781.A0A0P1A797; -.
DR EnsemblProtists; CEG36120; CEG36120; CEG36120.
DR OMA; TTWLYIN; -.
DR OrthoDB; 53550at2759; -.
DR Proteomes; UP000054928; Unassembled WGS sequence.
DR GO; GO:0004842; F:ubiquitin-protein transferase activity; IEA:InterPro.
DR CDD; cd11709; SPRY; 1.
DR CDD; cd14306; UBA_VP13D; 1.
DR Gene3D; 2.60.120.200; -; 1.
DR Gene3D; 2.60.120.920; -; 1.
DR Gene3D; 1.10.8.10; DNA helicase RuvA subunit, C-terminal domain; 1.
DR Gene3D; 3.30.2160.10; Hect, E3 ligase catalytic domain; 1.
DR Gene3D; 3.30.2410.10; Hect, E3 ligase catalytic domain; 1.
DR Gene3D; 3.90.1750.10; Hect, E3 ligase catalytic domains; 1.
DR Gene3D; 2.130.10.30; Regulator of chromosome condensation 1/beta-lactamase-inhibitor protein II; 3.
DR InterPro; IPR001870; B30.2/SPRY.
DR InterPro; IPR043136; B30.2/SPRY_sf.
DR InterPro; IPR013320; ConA-like_dom_sf.
DR InterPro; IPR000569; HECT_dom.
DR InterPro; IPR035983; Hect_E3_ubiquitin_ligase.
DR InterPro; IPR009091; RCC1/BLIP-II.
DR InterPro; IPR000408; Reg_chr_condens.
DR InterPro; IPR003877; SPRY_dom.
DR InterPro; IPR015940; UBA.
DR InterPro; IPR009060; UBA-like_sf.
DR InterPro; IPR041969; VP13D_UBA.
DR PANTHER; PTHR22870:SF24; BTB DOMAIN-CONTAINING PROTEIN; 1.
DR PANTHER; PTHR22870; REGULATOR OF CHROMOSOME CONDENSATION; 1.
DR Pfam; PF00632; HECT; 1.
DR Pfam; PF13385; Laminin_G_3; 1.
DR Pfam; PF00415; RCC1; 5.
DR Pfam; PF13540; RCC1_2; 1.
DR Pfam; PF00622; SPRY; 1.
DR PRINTS; PR00633; RCCNDNSATION.
DR SMART; SM00119; HECTc; 1.
DR SMART; SM00449; SPRY; 1.
DR SMART; SM00165; UBA; 1.
DR SUPFAM; SSF49899; Concanavalin A-like lectins/glucanases; 2.
DR SUPFAM; SSF56204; Hect, E3 ligase catalytic domain; 1.
DR SUPFAM; SSF50985; RCC1/BLIP-II; 2.
DR SUPFAM; SSF46934; UBA-like; 1.
DR PROSITE; PS50188; B302_SPRY; 1.
DR PROSITE; PS50237; HECT; 1.
DR PROSITE; PS00626; RCC1_2; 4.
DR PROSITE; PS50012; RCC1_3; 6.
DR PROSITE; PS50030; UBA; 1.
PE 4: Predicted;
KW Reference proteome {ECO:0000313|Proteomes:UP000054928};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW Ubl conjugation pathway {ECO:0000256|ARBA:ARBA00022786,
KW ECO:0000256|PROSITE-ProRule:PRU00104}.
FT REPEAT 597..648
FT /note="RCC1"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00235"
FT REPEAT 703..754
FT /note="RCC1"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00235"
FT REPEAT 760..811
FT /note="RCC1"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00235"
FT REPEAT 812..864
FT /note="RCC1"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00235"
FT REPEAT 865..928
FT /note="RCC1"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00235"
FT REPEAT 929..980
FT /note="RCC1"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00235"
FT DOMAIN 3121..3166
FT /note="UBA"
FT /evidence="ECO:0000259|PROSITE:PS50030"
FT DOMAIN 3595..3775
FT /note="B30.2/SPRY"
FT /evidence="ECO:0000259|PROSITE:PS50188"
FT DOMAIN 4161..4584
FT /note="HECT"
FT /evidence="ECO:0000259|PROSITE:PS50237"
FT REGION 1023..1059
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 3083..3125
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1024..1057
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 3095..3125
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT ACT_SITE 4548
FT /note="Glycyl thioester intermediate"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00104"
SQ SEQUENCE 4602 AA; 518334 MW; 501E3FBA56DFFD10 CRC64;
MQWSDACGTG YEPPGIALNH LQTLSRSDMR WGRLTYAQLI DEEFLAKQLR RLDCTQEARR
SGRLALLETK EMSLDKSIRQ RLMAAQLKAS RDASDDDEVE AKVETTDLFN TFHGGKKREL
LIAQCVLGNL QQPELATLMT TKLKEALSRL CTFPNPIYRL IFLRRQLIKS MHEATAFQHR
QWKATMEKNV HLVRCMEMSL HPSADEIQIG STDSTGMIGT IKHKAKVFRE AIIGLQMMLC
ILDGYNDSTV TTGTQKREFL ANLLLMLHEI APLALCTRRG NSSSYNFNLP RSSSTSNAAT
IAEFIEKVQK FLILMCPRPN TLSLTSPRLR AISKTSESEV LDRTNAIDGL IHLAAATGSV
RDFLVVLKVL LGATNSVLDA GRSESHITLS SRALYTASNP SLPSMYTSEV LSPDIDNHLT
KSKRSRPNSC KVANGHLLSA REIKDDTLLD ASRKKGLLKG IKVEAPNISV SKENIATLPS
GVSHHRPLYT SRGKNFVSKC FPTKIELKDA MKLGNFSPSV DVPAMKETLV RDSPMCTPIG
IARCPKIKNL NVRSVLIGLD GVKPCCPKQA SHGNSQSYNF CNVITGPNTL EEDERDREVW
SCGQNSYGEL GHGDTTSRKS FQRIQSLQHK EIIQIGAGNE HTIALTVDGR VFTCGYNDNG
QCGQGVTSRV AVWSEIHELG AINITQAHAY NGCEHTIFVT LDGQVVTCGY NYRGQLGHGN
TASESVPKVI QSLDNKIVRL VSCSYYHTIL TCEGGDNGQP FVFTFGRNDY GQLGHNDTID
RKIPQRIEAL NDEQIVSVAC GQYHTMVVTA GGKLFAFGKN DYGQLGVDSF ENQVVPVQVK
AGLENQECLE VRCGYYHTIV RCTGAHLYAF GRNDYGQLGL GRPNARASAI LQLQQQRFSY
ANLIEELEGK EIIRFACGCY HTIAVSDNGV LYVFGRNNHG QLGTGDTTER MYPFPIDDFA
GKRVAQVAAG FYHTVLLTGG IEDEKMEQEL VRNITGDTSS TLGCKGIDHL TILSSPTIEN
WLDPSKKSEN KSVGTLDVEK GEAFDNDTRD EDHQSPGQSD AETLIELFSD DALLVGLVIL
AQLDRLCQPF LPKPGSYPML QHPSLSVIEK LIKAKGPSFD TSYVFEESFE VFGIHTCSST
FESLAILLKH ISTRKIGKSS RFALAIKPIS TSHLQAYMLA ALIRILQANL SQLLRSSLAK
TTMLLSTEMS SPKEPTIDVK GWVNELDQTR LAILQIRDVL FSLVDIRRRR NVCYALDGIA
DEEGNTLRIA EEAIATLMEG YEIFFPCKCL RRQFFFHVMQ ENMNRDGSKY LCGLQCRSDL
WQIEMFPKSR KLLLEPLLNR MTEDALIVRC LPLQSQLEPS QTSLMHEMYQ TVFNRIATEF
SQRLGNVVGL QSSSKISPRP KSAQAFFRML QGMQKHLASW AASVQDWIIE DSVSEQSSAY
IESKVAYLID RTFRVDKNDL CHVPAQWRCF LEFTLMALQQ CSEVLRQILS MKSLPSPTRG
YTYSAELDSE KRLKIFETVE LSVVGQLLPL LVVHLLGFSN NTLFATALLP TLKTLLKFID
AFNQLDPAAE SAETQYVEMM ASCASFKSSE EEAIVLETTR RESECTFNPS QDIKSISSTG
MTSSNVMALP WNFRLEKEVA ILTTEMAMTL VVGNPIFTYS NVTSDHDKSS TQQVSNRWTN
SSLLQGGLKP NIVAQSINRR SFNSRIVQHT PFPTPESSPF SLILPPTLDD ERVLPLWQVP
TNQNYREIFG SLSIETFLMS FHYQRDFETQ NEAIAAATTL CTWIRDNYCK KDPSYRMLVR
QSQLAINSNA ILQSVEIQKN DLRIEAACFA ALIHHSLVGV HAYHFALMLQ QSAEERRSAP
PRTFIFLWQT VAQLRRNLAA QKTKIKNNFH LDSDTSQERS FDRIVALQQT ILDRCKLLLL
LDVYEEQEHC NVQLDAGYIA PYDPAFLVFV DSTCKFTASS AKRHLYTTYT DENLPFLIAF
PLSKWRILRT AFHSILRWKF TCRVSLRQVS QEILAFILSD EPVSSLNAIS KLLIDPCRRV
SCSTRGLENL QDLITMVSYD SIQADIVHQI SQVFVLQSST LSILTRSYAV GYFYLSLQNE
TFANLFGKLT EIMTDKAARL VNSKDSSTKS TILTLTLFLS AWGIHFDRKQ FESVSDIGVL
NVIQELMQNL TNRDEGNSCS EMLSSGEGFV NKRVQQTSRS NYFSQNQLAR LRNTLWIVFR
NICIHFAVQT KTSLNSQDID VPTLPVCSSV VQLLLDEAVS ISNHFLDFYR IKQIELTSSV
PVAARRSFEV ISQPRRFSCK NKGIIVSYDD MISSSRSDLN PPMSPLLKSS EFSVTTWLYI
NTELNRRTNC HELPDDFHDH QLVFLRGAGR EIALYLVLVP ESVDNWRIEV GITMHINQDS
EVGSFAGKCR MLERVVSKQV VASGTWSHVA IVLETTKIHL YLNGILDCQC SLAAQNSLIW
ATGSVNLPLH FGRFPSVFSM DRLAHSVSSA IQFLPCSLGI SNAAGWELTT TLSNNAIEHK
TKMLRCFDGW LSHFRFHNRS LSPIHVRVVF DEKKLATIVS SDGTQHLRIM ELHALIMLLS
SSSEGLVHFS SQFSKWVQLI WRTFLESNLV CIQQSSLRVL GALLPLGDPM KASNVLVHDD
PMTLDNFGFY TYDNLFVQQI IRMIGFCLYK CPYRIAGEFD SNTTVVPSSL MIARNIHINQ
FSLDIHDNLH QKTELQSNIE DQYQSSRRQS SVLANELNYL LQKLFKCSNA SWSQGIIRTI
SHSTQHCLSF QTKLIPSEDR FLQFGKHNLH FSTLKYVESV GCSYYLNGGA EFLRPGLTVE
LRGSRDRAHV VSLVSLPDTN NLPHSLAYVQ KDHGPAHKTW SNLSWYDKVF SPSCNVQLSK
VNIDELNPTQ VTGAHQTYST VIYDVASHPK GGRVLQTLVE KAAKVIPVVY NTKGNVQSQG
NGSKDSFNSV RNGAMLLKAL VQVAATEAGV DHLLAEPALL EFITELAVRE DKNIEHLTLY
QTEMCVNALR HEVYTALIEL EEEGEAELAS TANCENDSSE VGLSERTTLG RNVWEEEQVI
ETSRYRESPS FCLKLYNSEE VDREENRRAD ETWDQLDANE EEYEDEDEDE IFDGTDGEND
EEDEDESQFE LVEELMLMGF PEDWCILALK QTENDIVNAS AWIVDNLEYL SKLQSTLDKE
KNRNQGKFRC DEEEDDVVPY DDRLSGQPQL QSLETSIQSA TKNDDIESGS KFTSQALSLQ
QSFNVPILND KEMGRKVFGE MYFPFEEGGF LFNAKSRFMR SWRAGSIELK ETLMVNSSPH
ISNRAEASSA SFEENFDTEI RHLDLKHLGM KLWTLENTLS LMYARRCIVT FLHNLITSQR
GISSMQTWIS CEQWLKLLKL VLLRGDQFTI DSKRTRYPLE LSIDQVFSKA FQYFVDQDLA
TTAAAAFKFC LEQLEAAAME KVYEATLWTQ RSLIRSDQKV GQEPAIELVV WLLDLLLASP
NFIVISLPLD FLKGVMHQLR CCLGTTNLPT KFIVLRTISR LIRIMDTGKH DIVQDSQLVV
KDFIAAANLR HNRELGQGRL VFSQYLQSYI ELLCVLKGFM NDFHATSAKD VLDTKAQSLV
SFQSLSTPQS DGISLQFNRK RSCSSLLTIA EDDQSAIYHG NEVWNTACST IGFSTGIHSW
LVSIDKSNSP YLFVGVAARQ SNMDSYLGAD DQSWGFIGDK ALYYQRNRLR AYGESFKEGD
CIGVRLDCEK GELSFSKNGE DLGLAFENVV GEICPAVAFF SRHQKVSFIK NSCVSSGGNE
AWISSTGEEE HGSIHDCLTA CELMSNWVKK TSMCSTLAAA AFAMTTDWLR GTKKFVTTRS
GKSLWVDVTR ESCEKLGFYS GDRVRTPRGN AIVLGVANDR LWVDVDTESG SWFFHPSKLH
KLTSAKTTLL DSIELVNSDI SNPALESDPY LKRDEKECKL DVDDSTLETP MRHLIITQQE
LTEFGEHSLW TVAVDRELIA VVNDFCETSR INPWNLTPFQ LLNVVCGKTA VLELTSVAAV
LAMPREICEK MIIARFAILR YANVYISRAL PFFDLTWHYF LPDSNSLPCQ LISQCRGSIF
VSVKNTFWSS LMDRTALSLK RSDDEYDYPD DLPQLHVNRM KAAAAKCHQR DESSLFSSLF
GQSFEELHFL PVQTLRMVYS HPMDDGQFRT FKVRFEGEGV DDYGGPYREF FSQFFAELQM
LYGLESGNNT KLTTNDTHGE EPSGSSAKFD AGGSVSACLL PFFLPSPNWR NSVGANREKF
VLNSALLKDI AEEGGSSKEK RELYCEMFHF LGQMIGICLR TRVCVRLDFA MSVWKQLVAE
DDLSLESALE TLKEIDYVAY SLWKTLQGIL DDSKGQNMAK HMEQLQAMDL VFTTVLSDGQ
TVELCEDGIN TSVTMSNLKD YINLMLQARL QESRDVINII KQGLHSIMPV SALSLLTWTE
FEKRMCGVSE IDVKLLKDNT EYDEELSVND EFIQRFWRVL ESFELEDKRA FLRFVWARSR
LPSGSEQFQQ KFKIQALASS GSDGNSASST AGTSEQWMDS QMPKSHTCFF ALQLPRYSSD
EVCRERFLYA VHNCVEMDGD FRLADTEITG WTDINPTDQL RI
//
