GenomeNet

Database: UniProt
Entry: A0A0P1AC31_PLAHL
LinkDB: A0A0P1AC31_PLAHL
Original site: A0A0P1AC31_PLAHL 
ID   A0A0P1AC31_PLAHL        Unreviewed;       951 AA.
AC   A0A0P1AC31;
DT   20-JAN-2016, integrated into UniProtKB/TrEMBL.
DT   20-JAN-2016, sequence version 1.
DT   24-JAN-2024, entry version 27.
DE   SubName: Full=Hydroxymethylglutaryl-synthase {ECO:0000313|EMBL:CEG38447.1};
OS   Plasmopara halstedii (Downy mildew of sunflower).
OC   Eukaryota; Sar; Stramenopiles; Oomycota; Peronosporales; Peronosporaceae;
OC   Plasmopara.
OX   NCBI_TaxID=4781 {ECO:0000313|EMBL:CEG38447.1, ECO:0000313|Proteomes:UP000054928};
RN   [1] {ECO:0000313|Proteomes:UP000054928}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA   Sharma Rahul, Thines Marco;
RL   Submitted (SEP-2014) to the EMBL/GenBank/DDBJ databases.
CC   -!- SIMILARITY: Belongs to the thiolase-like superfamily. HMG-CoA synthase
CC       family. {ECO:0000256|ARBA:ARBA00007061}.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; CCYD01000322; CEG38447.1; -; Genomic_DNA.
DR   AlphaFoldDB; A0A0P1AC31; -.
DR   STRING; 4781.A0A0P1AC31; -.
DR   EnsemblProtists; CEG38447; CEG38447; CEG38447.
DR   OMA; QFSNSAY; -.
DR   OrthoDB; 1060at2759; -.
DR   Proteomes; UP000054928; Unassembled WGS sequence.
DR   GO; GO:0004421; F:hydroxymethylglutaryl-CoA synthase activity; IEA:InterPro.
DR   GO; GO:0006084; P:acetyl-CoA metabolic process; IEA:InterPro.
DR   GO; GO:0010142; P:farnesyl diphosphate biosynthetic process, mevalonate pathway; IEA:InterPro.
DR   CDD; cd00827; init_cond_enzymes; 1.
DR   Gene3D; 3.40.47.10; -; 3.
DR   InterPro; IPR013746; HMG_CoA_synt_C_dom.
DR   InterPro; IPR013528; HMG_CoA_synth_N.
DR   InterPro; IPR010122; HMG_CoA_synthase_euk.
DR   InterPro; IPR014030; Ketoacyl_synth_N.
DR   InterPro; IPR020841; PKS_Beta-ketoAc_synthase_dom.
DR   InterPro; IPR016039; Thiolase-like.
DR   NCBIfam; TIGR01833; HMG-CoA-S_euk; 1.
DR   PANTHER; PTHR43323; 3-HYDROXY-3-METHYLGLUTARYL COENZYME A SYNTHASE; 1.
DR   PANTHER; PTHR43323:SF2; 3-HYDROXY-3-METHYLGLUTARYL COENZYME A SYNTHASE; 1.
DR   Pfam; PF08540; HMG_CoA_synt_C; 1.
DR   Pfam; PF01154; HMG_CoA_synt_N; 1.
DR   Pfam; PF00109; ketoacyl-synt; 1.
DR   SUPFAM; SSF53901; Thiolase-like; 4.
DR   PROSITE; PS52004; KS3_2; 1.
PE   3: Inferred from homology;
KW   Reference proteome {ECO:0000313|Proteomes:UP000054928};
KW   Transferase {ECO:0000256|ARBA:ARBA00022679}.
FT   DOMAIN          485..951
FT                   /note="Ketosynthase family 3 (KS3)"
FT                   /evidence="ECO:0000259|PROSITE:PS52004"
FT   ACT_SITE        88
FT                   /note="Proton donor/acceptor"
FT                   /evidence="ECO:0000256|PIRSR:PIRSR610122-1"
FT   ACT_SITE        120
FT                   /note="Acyl-thioester intermediate"
FT                   /evidence="ECO:0000256|PIRSR:PIRSR610122-1"
FT   ACT_SITE        252
FT                   /note="Proton donor/acceptor"
FT                   /evidence="ECO:0000256|PIRSR:PIRSR610122-1"
FT   BINDING         212
FT                   /ligand="CoA"
FT                   /ligand_id="ChEBI:CHEBI:57287"
FT                   /evidence="ECO:0000256|PIRSR:PIRSR610122-2"
FT   BINDING         257
FT                   /ligand="CoA"
FT                   /ligand_id="ChEBI:CHEBI:57287"
FT                   /evidence="ECO:0000256|PIRSR:PIRSR610122-2"
FT   BINDING         261
FT                   /ligand="CoA"
FT                   /ligand_id="ChEBI:CHEBI:57287"
FT                   /evidence="ECO:0000256|PIRSR:PIRSR610122-2"
SQ   SEQUENCE   951 AA;  103553 MW;  552DD85A71D3CB37 CRC64;
     MEILTRPSNV GILAMEVHFP VTFVDQSEME AYDGVGSGKY TLGLGQVSMA VPGDREDVNA
     LALTVVSRLL NKYQVASEQI GRLEVGTETL VDKSKSTKTV LMQLFDNNTD VDGATVINAC
     YGGTAALLNA VAWVDSSLWD GRYALVVATD IAVYAEGPAR PSGGCGAVAM LIGADAPIIL
     DCRSKVTHTT NVWDFFKSNV TSEYPTVDGK LSNECYLHAL DECYQLFCKK QAFQGINREQ
     IGVSSFKYAV FHSPYHKLVQ KSFARLLFLD SRHFLANGNE AAKSKYISLT KWSKVPLYDT
     LNDRELDLAV RKLAAIEFQT TVLPSCTTSQ KIGNCYTAAV YMNLATLVHA RFTDLARGAR
     ILMFSYGSGS IASMFVLHTR EPSDSKSKFT LEKMAQSLDL TTRLERRIKL TPEEYSARLK
     LRQQSYSVSN GLQLTQSISS IPPGEFYLDH IDAMGRRFYA RSEPQDHVDI DTQHERVVKN
     IQELGGAVYV VGTSVGLPGQ TKVFEGEESV MKLLRGENCI SKLTSVDKKR MITQKIVHVQ
     KDMITGNITQ MPVSSVEECI QVSAVVARID LEKEYGIAAT IAHSMDDTTQ LAVAAGLEAV
     RNAGLADGIN GNWRLPEHLL DSTGVIYATS FPTMNAAVME TSRYFQKKDD PAYEMDRKIL
     FRLLVLANAQ VAQLTGARGP NTQINAACAG ATQAIGMAQD WISAGKCERV IVLSSDTASS
     EAMMPLIGGG FRALGAASIA PTAETAGRPF DVQRKGMIVG SGAVGIILES PRAFAERPMI
     RKKTVRLLAT QYSNSACHGA ALEPHHVGQE LVRFLSSIEN RFGITRSDIA RNGVYYSHET
     GTNASPTASC AYAEVTALRT AFGPELLSKL LITNTKGFTG HPMAVSFEDV AAIEGLRLKQ
     VPPVVHFETH DPNLGEDTHL RLASGGAYVH KYALRFAAGF GSQLAFSLYT T
//
DBGET integrated database retrieval system