ID A0A0P1AC31_PLAHL Unreviewed; 951 AA.
AC A0A0P1AC31;
DT 20-JAN-2016, integrated into UniProtKB/TrEMBL.
DT 20-JAN-2016, sequence version 1.
DT 24-JAN-2024, entry version 27.
DE SubName: Full=Hydroxymethylglutaryl-synthase {ECO:0000313|EMBL:CEG38447.1};
OS Plasmopara halstedii (Downy mildew of sunflower).
OC Eukaryota; Sar; Stramenopiles; Oomycota; Peronosporales; Peronosporaceae;
OC Plasmopara.
OX NCBI_TaxID=4781 {ECO:0000313|EMBL:CEG38447.1, ECO:0000313|Proteomes:UP000054928};
RN [1] {ECO:0000313|Proteomes:UP000054928}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Sharma Rahul, Thines Marco;
RL Submitted (SEP-2014) to the EMBL/GenBank/DDBJ databases.
CC -!- SIMILARITY: Belongs to the thiolase-like superfamily. HMG-CoA synthase
CC family. {ECO:0000256|ARBA:ARBA00007061}.
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DR EMBL; CCYD01000322; CEG38447.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A0P1AC31; -.
DR STRING; 4781.A0A0P1AC31; -.
DR EnsemblProtists; CEG38447; CEG38447; CEG38447.
DR OMA; QFSNSAY; -.
DR OrthoDB; 1060at2759; -.
DR Proteomes; UP000054928; Unassembled WGS sequence.
DR GO; GO:0004421; F:hydroxymethylglutaryl-CoA synthase activity; IEA:InterPro.
DR GO; GO:0006084; P:acetyl-CoA metabolic process; IEA:InterPro.
DR GO; GO:0010142; P:farnesyl diphosphate biosynthetic process, mevalonate pathway; IEA:InterPro.
DR CDD; cd00827; init_cond_enzymes; 1.
DR Gene3D; 3.40.47.10; -; 3.
DR InterPro; IPR013746; HMG_CoA_synt_C_dom.
DR InterPro; IPR013528; HMG_CoA_synth_N.
DR InterPro; IPR010122; HMG_CoA_synthase_euk.
DR InterPro; IPR014030; Ketoacyl_synth_N.
DR InterPro; IPR020841; PKS_Beta-ketoAc_synthase_dom.
DR InterPro; IPR016039; Thiolase-like.
DR NCBIfam; TIGR01833; HMG-CoA-S_euk; 1.
DR PANTHER; PTHR43323; 3-HYDROXY-3-METHYLGLUTARYL COENZYME A SYNTHASE; 1.
DR PANTHER; PTHR43323:SF2; 3-HYDROXY-3-METHYLGLUTARYL COENZYME A SYNTHASE; 1.
DR Pfam; PF08540; HMG_CoA_synt_C; 1.
DR Pfam; PF01154; HMG_CoA_synt_N; 1.
DR Pfam; PF00109; ketoacyl-synt; 1.
DR SUPFAM; SSF53901; Thiolase-like; 4.
DR PROSITE; PS52004; KS3_2; 1.
PE 3: Inferred from homology;
KW Reference proteome {ECO:0000313|Proteomes:UP000054928};
KW Transferase {ECO:0000256|ARBA:ARBA00022679}.
FT DOMAIN 485..951
FT /note="Ketosynthase family 3 (KS3)"
FT /evidence="ECO:0000259|PROSITE:PS52004"
FT ACT_SITE 88
FT /note="Proton donor/acceptor"
FT /evidence="ECO:0000256|PIRSR:PIRSR610122-1"
FT ACT_SITE 120
FT /note="Acyl-thioester intermediate"
FT /evidence="ECO:0000256|PIRSR:PIRSR610122-1"
FT ACT_SITE 252
FT /note="Proton donor/acceptor"
FT /evidence="ECO:0000256|PIRSR:PIRSR610122-1"
FT BINDING 212
FT /ligand="CoA"
FT /ligand_id="ChEBI:CHEBI:57287"
FT /evidence="ECO:0000256|PIRSR:PIRSR610122-2"
FT BINDING 257
FT /ligand="CoA"
FT /ligand_id="ChEBI:CHEBI:57287"
FT /evidence="ECO:0000256|PIRSR:PIRSR610122-2"
FT BINDING 261
FT /ligand="CoA"
FT /ligand_id="ChEBI:CHEBI:57287"
FT /evidence="ECO:0000256|PIRSR:PIRSR610122-2"
SQ SEQUENCE 951 AA; 103553 MW; 552DD85A71D3CB37 CRC64;
MEILTRPSNV GILAMEVHFP VTFVDQSEME AYDGVGSGKY TLGLGQVSMA VPGDREDVNA
LALTVVSRLL NKYQVASEQI GRLEVGTETL VDKSKSTKTV LMQLFDNNTD VDGATVINAC
YGGTAALLNA VAWVDSSLWD GRYALVVATD IAVYAEGPAR PSGGCGAVAM LIGADAPIIL
DCRSKVTHTT NVWDFFKSNV TSEYPTVDGK LSNECYLHAL DECYQLFCKK QAFQGINREQ
IGVSSFKYAV FHSPYHKLVQ KSFARLLFLD SRHFLANGNE AAKSKYISLT KWSKVPLYDT
LNDRELDLAV RKLAAIEFQT TVLPSCTTSQ KIGNCYTAAV YMNLATLVHA RFTDLARGAR
ILMFSYGSGS IASMFVLHTR EPSDSKSKFT LEKMAQSLDL TTRLERRIKL TPEEYSARLK
LRQQSYSVSN GLQLTQSISS IPPGEFYLDH IDAMGRRFYA RSEPQDHVDI DTQHERVVKN
IQELGGAVYV VGTSVGLPGQ TKVFEGEESV MKLLRGENCI SKLTSVDKKR MITQKIVHVQ
KDMITGNITQ MPVSSVEECI QVSAVVARID LEKEYGIAAT IAHSMDDTTQ LAVAAGLEAV
RNAGLADGIN GNWRLPEHLL DSTGVIYATS FPTMNAAVME TSRYFQKKDD PAYEMDRKIL
FRLLVLANAQ VAQLTGARGP NTQINAACAG ATQAIGMAQD WISAGKCERV IVLSSDTASS
EAMMPLIGGG FRALGAASIA PTAETAGRPF DVQRKGMIVG SGAVGIILES PRAFAERPMI
RKKTVRLLAT QYSNSACHGA ALEPHHVGQE LVRFLSSIEN RFGITRSDIA RNGVYYSHET
GTNASPTASC AYAEVTALRT AFGPELLSKL LITNTKGFTG HPMAVSFEDV AAIEGLRLKQ
VPPVVHFETH DPNLGEDTHL RLASGGAYVH KYALRFAAGF GSQLAFSLYT T
//