ID   A0A0P1AQD9_PLAHL        Unreviewed;       327 AA.
AC   A0A0P1AQD9;
DT   20-JAN-2016, integrated into UniProtKB/TrEMBL.
DT   20-JAN-2016, sequence version 1.
DT   27-MAR-2024, entry version 29.
DE   RecName: Full=Ubiquitin-like 1-activating enzyme E1A {ECO:0000256|ARBA:ARBA00044354};
OS   Plasmopara halstedii (Downy mildew of sunflower).
OC   Eukaryota; Sar; Stramenopiles; Oomycota; Peronosporales; Peronosporaceae;
OC   Plasmopara.
OX   NCBI_TaxID=4781 {ECO:0000313|EMBL:CEG43341.1, ECO:0000313|Proteomes:UP000054928};
RN   [1] {ECO:0000313|Proteomes:UP000054928}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA   Sharma Rahul, Thines Marco;
RL   Submitted (SEP-2014) to the EMBL/GenBank/DDBJ databases.
CC   -!- PATHWAY: Protein modification; protein sumoylation.
CC       {ECO:0000256|ARBA:ARBA00004718}.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|ARBA:ARBA00004123}.
CC   -!- SIMILARITY: Belongs to the ubiquitin-activating E1 family.
CC       {ECO:0000256|ARBA:ARBA00005673}.
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DR   EMBL; CCYD01000653; CEG43341.1; -; Genomic_DNA.
DR   AlphaFoldDB; A0A0P1AQD9; -.
DR   STRING; 4781.A0A0P1AQD9; -.
DR   EnsemblProtists; CEG43341; CEG43341; CEG43341.
DR   OMA; EFFGQFD; -.
DR   OrthoDB; 5483037at2759; -.
DR   Proteomes; UP000054928; Unassembled WGS sequence.
DR   GO; GO:0008641; F:ubiquitin-like modifier activating enzyme activity; IEA:InterPro.
DR   GO; GO:0036211; P:protein modification process; IEA:InterPro.
DR   Gene3D; 3.40.50.720; NAD(P)-binding Rossmann-like Domain; 1.
DR   InterPro; IPR045886; ThiF/MoeB/HesA.
DR   InterPro; IPR000594; ThiF_NAD_FAD-bd.
DR   InterPro; IPR035985; Ubiquitin-activating_enz.
DR   InterPro; IPR000011; UBQ/SUMO-activ_enz_E1-like.
DR   PANTHER; PTHR10953:SF162; SUMO-ACTIVATING ENZYME SUBUNIT 1; 1.
DR   PANTHER; PTHR10953; UBIQUITIN-ACTIVATING ENZYME E1; 1.
DR   Pfam; PF00899; ThiF; 1.
DR   PRINTS; PR01849; UBIQUITINACT.
DR   SUPFAM; SSF69572; Activating enzymes of the ubiquitin-like proteins; 1.
PE   3: Inferred from homology;
KW   Nucleus {ECO:0000256|ARBA:ARBA00023242};
KW   Reference proteome {ECO:0000313|Proteomes:UP000054928};
KW   Ubl conjugation pathway {ECO:0000256|ARBA:ARBA00022786}.
FT   DOMAIN          23..322
FT                   /note="THIF-type NAD/FAD binding fold"
FT                   /evidence="ECO:0000259|Pfam:PF00899"
SQ   SEQUENCE   327 AA;  36267 MW;  399F3CA151C0180F CRC64;
     MTSLKEEMTE QATTFSVEEA ALYDRQMRLW GVEAQKRLQN SHVLISGLSA LGSELVKNLV
     LAGINVTLHD LKITTHAAAS IQFLLSDDDV GKNRAEACLP RVQELNPLAK VLCETKALED
     YSDDYFKQFT VVCLIGAAQS TELRLDVLCR SLGIAFYAAR TFGFDGIVFA DLGNYTFRRD
     AIGTDVATSD PIPVTFPTLE QAQKIKWSSL QSARKRAPQL PKVFVKNQLL QGYKSVKGIQ
     KITEDLVVDF IRYAREEFEK NGLGDDYMTL DELQQLLRAA DIDLVPVCAI VAGILGQEVI
     KAISQKDEPI CNYFCFDGVS GIVRKIG
//