ID   A0A0P1AXQ0_PLAHL        Unreviewed;      1093 AA.
AC   A0A0P1AXQ0;
DT   20-JAN-2016, integrated into UniProtKB/TrEMBL.
DT   20-JAN-2016, sequence version 1.
DT   27-MAR-2024, entry version 38.
DE   SubName: Full=Ras guanine nucleotide exchange factor {ECO:0000313|EMBL:CEG46223.1};
OS   Plasmopara halstedii (Downy mildew of sunflower).
OC   Eukaryota; Sar; Stramenopiles; Oomycota; Peronosporales; Peronosporaceae;
OC   Plasmopara.
OX   NCBI_TaxID=4781 {ECO:0000313|EMBL:CEG46223.1, ECO:0000313|Proteomes:UP000054928};
RN   [1] {ECO:0000313|Proteomes:UP000054928}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA   Sharma Rahul, Thines Marco;
RL   Submitted (SEP-2014) to the EMBL/GenBank/DDBJ databases.
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DR   EMBL; CCYD01002047; CEG46223.1; -; Genomic_DNA.
DR   AlphaFoldDB; A0A0P1AXQ0; -.
DR   STRING; 4781.A0A0P1AXQ0; -.
DR   EnsemblProtists; CEG46223; CEG46223; CEG46223.
DR   OMA; MEANVSI; -.
DR   OrthoDB; 68574at2759; -.
DR   Proteomes; UP000054928; Unassembled WGS sequence.
DR   GO; GO:0005085; F:guanyl-nucleotide exchange factor activity; IEA:UniProtKB-KW.
DR   GO; GO:0007264; P:small GTPase mediated signal transduction; IEA:InterPro.
DR   CDD; cd06224; REM; 1.
DR   Gene3D; 1.10.840.10; Ras guanine-nucleotide exchange factors catalytic domain; 1.
DR   Gene3D; 1.20.870.10; Son of sevenless (SoS) protein Chain: S domain 1; 1.
DR   InterPro; IPR008937; Ras-like_GEF.
DR   InterPro; IPR000651; Ras-like_Gua-exchang_fac_N.
DR   InterPro; IPR023578; Ras_GEF_dom_sf.
DR   InterPro; IPR001895; RASGEF_cat_dom.
DR   InterPro; IPR036964; RASGEF_cat_dom_sf.
DR   PANTHER; PTHR23113:SF254; CYCLIC GMP-BINDING PROTEIN D; 1.
DR   PANTHER; PTHR23113; GUANINE NUCLEOTIDE EXCHANGE FACTOR; 1.
DR   Pfam; PF00617; RasGEF; 1.
DR   Pfam; PF00618; RasGEF_N; 1.
DR   SMART; SM00147; RasGEF; 1.
DR   SMART; SM00229; RasGEFN; 1.
DR   SUPFAM; SSF48366; Ras GEF; 1.
DR   PROSITE; PS50009; RASGEF_CAT; 1.
DR   PROSITE; PS50212; RASGEF_NTER; 1.
PE   4: Predicted;
KW   Guanine-nucleotide releasing factor {ECO:0000256|ARBA:ARBA00022658,
KW   ECO:0000256|PROSITE-ProRule:PRU00168};
KW   Reference proteome {ECO:0000313|Proteomes:UP000054928}.
FT   DOMAIN          414..582
FT                   /note="N-terminal Ras-GEF"
FT                   /evidence="ECO:0000259|PROSITE:PS50212"
FT   DOMAIN          819..1048
FT                   /note="Ras-GEF"
FT                   /evidence="ECO:0000259|PROSITE:PS50009"
FT   REGION          29..88
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          100..215
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          233..397
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        29..59
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        71..88
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        106..124
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        140..154
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        161..191
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        233..276
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        277..292
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        318..332
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        350..366
FT                   /note="Pro residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        380..397
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   1093 AA;  119879 MW;  4085D38D93EFE348 CRC64;
     MAHNHPAAVT VATDRAPLLV ARNLLPSDAS VSNSSIKAEA STTSVKSSSL SSSVAAIDAQ
     SRRQRDRKCT GDSTVTSTSS STTSLSLDIS SAAVPNTFRR ARHHTSHNQP VNDSKNDRRS
     PSYQASHSRH RRQPSRDAHA GDGQVSSDSG LNLLVSPLPA SEHDSCSSSG GQASDKEENT
     VTEQQRQEPV TIKPSRMVVK RRATAPASSS AARRTSVGLA TIPLSPNQQF CRSVDKASAT
     SSPRWKSSSP LTHGLSASIQ RSTSTLEKWQ HRLQRSISGG TDDERARREP SSSRRLYSNC
     CSHQLLESPP PPDEIVATRR TRGNDKTSIK VKIRTRSSSR GSKQPVSPRT IGGLPPPSPP
     PPLSLSSDEQ MGPTTPRALA RKIPHRDKNS SDEKISKPRP VRIRYESSAR GMGGKREISH
     ASLGKLIAHL TDAHQFDTEF RDVFLLTYRS FCSPYDFIKK LLKRYTAVLS LCGNIDAERL
     EEIQRLLDQI TLEEENEQRS SNVTSVSTAK SDINTGMEAN VSIMRLLSVL KFWIKESTFI
     EQDLANDRKA QKKLIALLKE IEKSSPIPSV RRHAETLLLT VAQVLSTLKQ QAQQAQITQA
     HTQAQAKAQS QRGPAKVSTP LMLVTSSSVS SIPDRAGSRP AVDDPLSAAA SVIERHNDHG
     EVSSRICTKL ALPRSSSDPK RERSMVKLRS KNPHVDIIQI RSRSVPNGID DSAVAAAASR
     DRAVRSGAVP IAAAVAPKIA RGITTGSAEA VNRATGNTEA VNKTNGSSET MNRANGSGNI
     ANGFDELIKD TLQRARLTAT SRKSARISYG NVEPLTGLTA QELADQLTLI EAEQYFAKLN
     PRELTNKAWT RENKHRDAPH VMALIELFDA IAEWVSSEIL HPQLQAVERA KMITLFIDTA
     DHCYQMNNFN SLFEISTGLS APCIRQLNTT WSLVSAAASE KYQCLQQLCS PDENYRSYRQ
     AFGLAEGQPR LACWFILVKD LFTYEEAMKS VEDGLVNWHK FRKIYRVISD AIDVQNFNYV
     PPNTGANGSG NGMSGVSRKG RGILRHDKKN QIHIRHRIDT IRKDSSVLYQ LARNANTQES
     ILFVNSLSEA GFL
//