ID A0A0P1B0L6_PLAHL Unreviewed; 4282 AA.
AC A0A0P1B0L6;
DT 20-JAN-2016, integrated into UniProtKB/TrEMBL.
DT 20-JAN-2016, sequence version 1.
DT 27-MAR-2024, entry version 33.
DE SubName: Full=Dynein heavy chain axonemal {ECO:0000313|EMBL:CEG47570.1};
OS Plasmopara halstedii (Downy mildew of sunflower).
OC Eukaryota; Sar; Stramenopiles; Oomycota; Peronosporales; Peronosporaceae;
OC Plasmopara.
OX NCBI_TaxID=4781 {ECO:0000313|EMBL:CEG47570.1, ECO:0000313|Proteomes:UP000054928};
RN [1] {ECO:0000313|Proteomes:UP000054928}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Sharma Rahul, Thines Marco;
RL Submitted (SEP-2014) to the EMBL/GenBank/DDBJ databases.
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DR EMBL; CCYD01002601; CEG47570.1; -; Genomic_DNA.
DR STRING; 4781.A0A0P1B0L6; -.
DR EnsemblProtists; CEG47570; CEG47570; CEG47570.
DR OMA; FFQSCAK; -.
DR OrthoDB; 312149at2759; -.
DR Proteomes; UP000054928; Unassembled WGS sequence.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-KW.
DR GO; GO:0030286; C:dynein complex; IEA:UniProtKB-KW.
DR GO; GO:0005874; C:microtubule; IEA:UniProtKB-KW.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0045505; F:dynein intermediate chain binding; IEA:InterPro.
DR GO; GO:0051959; F:dynein light intermediate chain binding; IEA:InterPro.
DR GO; GO:0008569; F:minus-end-directed microtubule motor activity; IEA:InterPro.
DR GO; GO:0007018; P:microtubule-based movement; IEA:InterPro.
DR Gene3D; 1.10.287.2620; -; 1.
DR Gene3D; 1.10.472.130; -; 1.
DR Gene3D; 1.10.8.1220; -; 1.
DR Gene3D; 1.10.8.710; -; 1.
DR Gene3D; 1.20.1270.280; -; 1.
DR Gene3D; 1.20.58.1120; -; 1.
DR Gene3D; 1.20.920.20; -; 1.
DR Gene3D; 1.20.920.30; -; 1.
DR Gene3D; 3.10.490.20; -; 1.
DR Gene3D; 6.10.140.1060; -; 1.
DR Gene3D; 1.20.140.100; Dynein heavy chain, N-terminal domain 2; 1.
DR Gene3D; 3.20.180.20; Dynein heavy chain, N-terminal domain 2; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 5.
DR Gene3D; 1.10.8.720; Region D6 of dynein motor; 1.
DR InterPro; IPR035699; AAA_6.
DR InterPro; IPR035706; AAA_9.
DR InterPro; IPR041658; AAA_lid_11.
DR InterPro; IPR042219; AAA_lid_11_sf.
DR InterPro; IPR026983; DHC_fam.
DR InterPro; IPR041589; DNAH3_AAA_lid_1.
DR InterPro; IPR042222; Dynein_2_N.
DR InterPro; IPR043157; Dynein_AAA1S.
DR InterPro; IPR041466; Dynein_AAA5_ext.
DR InterPro; IPR041228; Dynein_C.
DR InterPro; IPR043160; Dynein_C_barrel.
DR InterPro; IPR024743; Dynein_HC_stalk.
DR InterPro; IPR024317; Dynein_heavy_chain_D4_dom.
DR InterPro; IPR004273; Dynein_heavy_D6_P-loop.
DR InterPro; IPR013602; Dynein_heavy_linker.
DR InterPro; IPR042228; Dynein_linker_3.
DR InterPro; IPR027417; P-loop_NTPase.
DR PANTHER; PTHR45703; DYNEIN HEAVY CHAIN; 1.
DR PANTHER; PTHR45703:SF1; DYNEIN HEAVY CHAIN; 1.
DR Pfam; PF12774; AAA_6; 1.
DR Pfam; PF12775; AAA_7; 1.
DR Pfam; PF12780; AAA_8; 1.
DR Pfam; PF12781; AAA_9; 1.
DR Pfam; PF17857; AAA_lid_1; 1.
DR Pfam; PF18198; AAA_lid_11; 1.
DR Pfam; PF08393; DHC_N2; 1.
DR Pfam; PF17852; Dynein_AAA_lid; 1.
DR Pfam; PF18199; Dynein_C; 1.
DR Pfam; PF03028; Dynein_heavy; 1.
DR Pfam; PF12777; MT; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 4.
PE 4: Predicted;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840};
KW Coiled coil {ECO:0000256|ARBA:ARBA00023054, ECO:0000256|SAM:Coils};
KW Cytoplasm {ECO:0000256|ARBA:ARBA00022490};
KW Cytoskeleton {ECO:0000256|ARBA:ARBA00023212};
KW Dynein {ECO:0000256|ARBA:ARBA00023017};
KW Microtubule {ECO:0000256|ARBA:ARBA00022701};
KW Motor protein {ECO:0000256|ARBA:ARBA00023175};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741};
KW Reference proteome {ECO:0000313|Proteomes:UP000054928}.
FT DOMAIN 991..1405
FT /note="Dynein heavy chain linker"
FT /evidence="ECO:0000259|Pfam:PF08393"
FT DOMAIN 1548..1874
FT /note="Dynein heavy chain hydrolytic ATP-binding dynein
FT motor region"
FT /evidence="ECO:0000259|Pfam:PF12774"
FT DOMAIN 2033..2182
FT /note="Dynein heavy chain AAA 5 extension"
FT /evidence="ECO:0000259|Pfam:PF17852"
FT DOMAIN 2402..2495
FT /note="Dynein heavy chain 3 AAA+ lid"
FT /evidence="ECO:0000259|Pfam:PF17857"
FT DOMAIN 2568..2830
FT /note="Dynein heavy chain AAA module D4"
FT /evidence="ECO:0000259|Pfam:PF12780"
FT DOMAIN 2849..3189
FT /note="Dynein heavy chain coiled coil stalk"
FT /evidence="ECO:0000259|Pfam:PF12777"
FT DOMAIN 3220..3441
FT /note="Dynein heavy chain ATP-binding dynein motor region"
FT /evidence="ECO:0000259|Pfam:PF12781"
FT DOMAIN 3686..3796
FT /note="Dynein heavy chain region D6 P-loop"
FT /evidence="ECO:0000259|Pfam:PF03028"
FT DOMAIN 3832..3969
FT /note="Dynein heavy chain AAA lid"
FT /evidence="ECO:0000259|Pfam:PF18198"
FT DOMAIN 3976..4277
FT /note="Dynein heavy chain C-terminal"
FT /evidence="ECO:0000259|Pfam:PF18199"
FT COILED 922..982
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 3073..3124
FT /evidence="ECO:0000256|SAM:Coils"
SQ SEQUENCE 4282 AA; 486175 MW; C35DA168DD45732C CRC64;
MKGQGENEDL IKNVVRGSPK RSPVRLARLK MLQSAIKTRN CDFREQTNNI SYRCERRSDR
LEGSLNEILE NLGPLGGLRG SVLNGSKARL NEEPKPSEDR EYYRISDRIG AFYTQSARAL
TIDKISTFTK RELEMPVAKA KFSIRSPSKI MAKCPALEHN SLEDSSAVKN SLILSEESED
KVLIQQLNGA VDSSRIYTRH VETSRGIFLS PSPTKPNRQS PRPRSQFALD MKNKTLHLEI
METNARLFED EKRQFVTTME NYWKHVDLYI IAARTVPMPS ECPSRILRRL QVPAPTGLNN
EAVKKIDEQS EAMIAAISQE MYANYHEAVA RSMLKYDLLN ASTCIRLQIN PLYLQAEQKW
WVDESYRSWD WRVLRRTGIY RERIELARSR LHQTLFAINP VTSALQEQWI METPPSEWEL
VPTGKRAPYA TILFVEVHRP EFQATLPKTV LHFVDTISKR ASLVKDCLKT CWVTAAADRV
NDCALQLQYY TLQSSEPTIM SSFANGCLSR KDACNSQSIT TCSPKRKAHH KHLRKGSIEK
DRSQFFRLNS PPRDIETEDY SQFIGVLDAA AVLMARNLRE SVETSITKFV DFIRQYSNQT
FTGESALLLG VDCITTSEIV DTNSIMFFID PSPNVLREKI ASCVDVIVEA SHSLPRIDSQ
TRLPPKLCKS RPLGPSTMAL DDKVVIKAKN TLAELIAEHM HDPSAILALF EPYNFVISGE
YEAKLEKLIE SSDKALQGED EDEPKTVFDI LKGYRNEIKE LDLVESRLKN EISEKYSFRL
LAISCAEVKV KLANKMKALA QRLLSKVAAD NSKKMSTLIT EYEQIAATLI AEPIDSFELK
ALHKFYISSI KVIDTLNTKV YEDVCRYIHF LKEFDYQMTR EDIQLFFKTF RWPENIKGFQ
RKSMELQGKR HHELELIVDG QQEQLTNQLV SLQRRIEKMR NFANLTDSDS ILRRIEAVRK
GLEEAEAEAE LIQEQETMLE KTGSDNQTTL TDLHNMLSPI DKLWSTIAQT MDKMTLSRSA
PLASVNAEEI ERDCDQFRRT IGKILKECEQ NTEVYSVAIT MAQEVKNRLD DMFENVLPLM
MLVCTPGMRE RHWNDIERIT GIHVNVHSKS NINQMIELGL HRYTSAIEET CVNAFKEYSL
EKALDKMASE WVGVNFETKT YRSTGTSILC STDEIQQVID DQIVKTQSMR GSQYNKPYLE
RILKWEKMLI SIQDIMDHWI KVQATWLYLE PIFSSEDIMR QMPIEGALFQ KVDANWRRNM
QDTVAFPAVL TVAKRSDLLP SLQQSSLDLD AIQKGLNDYL ETKRIYFPRF FFLSNDELLE
ILAETKDPLR VQPHLKKAFD GINQLEFQKN LDISAMLSPE MEKVPFHYEK IAQKRINPTQ
SGGNVEIWLE EVEMAMKKSV AFYLDESIVE YSTKERLEWV QQWPGQVVLA VNQTMWTQQS
EKALYNCATD SKALKNYLDI LRTELKRTVE MVRGELPKLI RITLGALVVM DVHNRDTIAE
LVELKIIDPT AFDWLAQLRY YWIQGRVSAT SGKPHTLECR MINTLALYAF EYLGNSMRLV
ITPLTDRCYR TLTGAIHLNL GGAPEGPAGT GKTETTKDLA KAIAIQCVVT NCSDGLDYLA
MGKFFKGLAS SGAWACFDEF NRIQLEVLSV IAQQILCIQL AKAQHVATFV FEGTELRLNP
TCCPFITMNP GYAGRAELPD NLKVLFRTVA MMVPDYAMIA EIMLYSYGYL DASALSKKIT
TTYTLCSEQL SSQSHYDYGM RAVMAVLRAA GNLKRAEAHL REDTLVLRSI IDVNLPKFLS
PDVPLFHGIV SDLFPGVKID PPDRRDMLST IDFVCKQLNL QPVPNFVEKV IQMYEMMLVR
HGFMVVGMPF SGKTCAWRVL SEVLASLHQQ FPNDSRYTNV AISVINPKSV TMGQLYGQFD
AISHEWNDGV LAINYRNLAN NPSLDRKWLL FDGPVDAVWI ENMNTVLDDN RKLCLMSGEI
IAMSPVMSMM FEPMDLLVAS PATVSRCAGD GSKEPVSGPF EINFDQRKLI FFLFSWLVEP
CIAFVRKELT ELSPTVDSNL VQSLIHILEA QLSKLPRDAS SKKKATIESL FVFSLAWSVS
ESINAEGRLK LCNFVRAIMD DLSALETKFS AINRALQVRK WEKPAFDDGK STYTLAIPVP
INGNLHDYYF SLDETKWCKW EERLKPYVIP PNTPFNQIVV PTIFTAQLEY LVQLLVSNKR
KILVCGPTGT GKSCYMTSIL NEVLPQDQNS IIMLSFSAKT SANMTQNIID GKVDKRRKGV
FGPPVGKNAI IFVDDLNMPL VEAYGAQPPI ELVRQLIDNG GYYDLKDMSW RKIVDTIVLA
AMGPPGGGRN HITPRLLRHF NLLCFSEFDN TTLIRIFTTI LDWYFSSHPF NSEVTRLSET
VVSATLELYQ SAMMSLLPTP QKSHYTFNLR DFSRIVQGMM LVVPNDEFRT TSLVKVWVHE
SLRVIGDRLI DEDDREWFST TQKNIVLKHF ATNFDQVFVS LKRGQEGPVT HVDMRNLFFG
NYVVSNASPR QYQEVDVHLD TTFDGIAHLI QCFERYLTEY NSMSRKPMNL VMFLFAIEHL
SRIARVLNMP GGNALLVGVG GSGRQSLTRL AAFIVDFDLQ QIEISKNYTM NEWREDLKTV
LRSAGTGARP VVFLFSDTQI KYDGFVEDIN NMLNSGEIPN LFMYDEIVGL CEAVRPHVKE
KLGKIVGDNL TQPQLYAFFR QRVRSNLHIV LACSPIGDAF RDRLRKFPSL INCCTIDWFT
AWPSDALVAV AEKFLADVAM DSVNIRNAIV DTCQFFHVSI TKLSDQFLKN LRRKNYVTPT
SYLELIVAFK GFLLRRREAV ECARSRYVIG LDKISFAESN VAVMRAELED LQPVLDQSTK
DTDMLMFEIK AKLPGVEIQR SEVQADVAVA DASKAECEHQ KASVEADLAE AIPALEEALK
ALDTIKPSEI NEVKAMSNPP AGVKFVCEGV CVMLGIKPAR IPDPQDPSKR IMDFWGPSQK
MLSDPTFITT LKKFDKDNLD PKTMKLVVSK YISDENFSPE KAEKASKAAA GLCKWVHAMA
LYDNVSKVVA PKREALRVAE EELAEVMQKL NEKLTQLKDV EEDLAALQRQ FDLATKQKEN
LEFQVELTGK KLVRASTLIE SLGGEKTRWT EFAEQLVDQY SRLTGDVLIS AGVVAYLGPF
TSVYRQDAVH GWVNRCKQLE IPCSDFPSLN GSLGDAVKIR KWKLDGLPTD GFSIDNGIIV
FNSRRWPLMI DPQGQANKWI RNMEKDNQMK VIKLTDGDYM RTLENSVQFG TPVLLENIGE
ELDPSLEPLL LKQTFKQGGV TCIRLGDTTV EYAESFRFYM TTKYRNPHYL PEVSVKVTLV
NFMITPHGLE DQLLGIVVAQ ERPDLEEQKH RLIVQNVRNK GLLKEIEDKI LSILSSSQGN
ILEDEEAINT MNQSKTVADA IQKEQQVAEK TELEIDSVRQ GYQPVAYSSQ VLFFCIDQLA
NIEPVYQYSL SWFINLFIAS ILNSERSPDL TQRLRYLDNH FTFSLYRNIC RSLLEKDKLM
FSFVLCTSIK QGKHEIESNE WYFLLTGGVA LSEPPSNPIK SWLSDQQWAE FSRLSTLPAF
NGILEDLVDH ENQWKAIYDS SVGHTLPFPG TIGKKLEFHR LLILRCIRPD LLVVGIQQFI
ANEMGDKFVK PPPFDLARSF TDSSVSSPLV FILSPGSDPI SSVLKFADSM HQKIETISLG
QGQGPIAERM IERAREAGSW VVLQNCHLAP SWMPVMEKIA EDITLENTLP DFRLWCTTYP
SDVFPPAVLQ NGVKMTNEPP QGLRANLLGS YLSDPIAEIG FLDAVKQGPA FRILLYSLCF
FHALVRERRQ FGPLGWNIPY EFNESDLSIS IRQLAMFIDE NEQLPLRALN YCTGECNYGG
RVTDDKDRRT LMSLLSRFYC QNVVEDGYAF DEHGVYTVPN DGDYDSYLNF IENLPLVASP
GVFGLHDNAT ITKDQNASMK LCHDVLLTES SSGGKEGSNG SSQETLVDVV ASEILIRLPS
NYDMEVAQLR YPVRWDESMN TVLCQELVRF NTLLSTIRSS LESLRKALKG LVVMSAELEN
VSNNLFYGKI PLHWASRSYP SLKPLGSYVT DLLDRLSYFN NWLLNDPPVV FWLSGFFFTQ
AFLTGASQNY ARKHTVPIDQ LGFDHEPMPQ TEYEQPPKDG VYVRGLYLEG AKWDKNSTAL
VESDAKVLFS LAPVLLFRPT KKSALSQRLT YSCPVYKTSE RRGTLSTTGH STNFICFIRL
PTIKPETHWV ARGVAMLSQL DD
//
