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Database: UniProt
Entry: A0A0P1E8S0_9RHOB
LinkDB: A0A0P1E8S0_9RHOB
Original site: A0A0P1E8S0_9RHOB 
ID   A0A0P1E8S0_9RHOB        Unreviewed;       420 AA.
AC   A0A0P1E8S0;
DT   20-JAN-2016, integrated into UniProtKB/TrEMBL.
DT   20-JAN-2016, sequence version 1.
DT   16-JAN-2019, entry version 17.
DE   RecName: Full=Phosphoribosylamine--glycine ligase {ECO:0000256|HAMAP-Rule:MF_00138};
DE            EC=6.3.4.13 {ECO:0000256|HAMAP-Rule:MF_00138};
DE   AltName: Full=GARS {ECO:0000256|HAMAP-Rule:MF_00138};
DE   AltName: Full=Glycinamide ribonucleotide synthetase {ECO:0000256|HAMAP-Rule:MF_00138};
DE   AltName: Full=Phosphoribosylglycinamide synthetase {ECO:0000256|HAMAP-Rule:MF_00138};
GN   Name=purD {ECO:0000256|HAMAP-Rule:MF_00138,
GN   ECO:0000313|EMBL:CUH44918.1};
GN   ORFNames=RUM4293_03827 {ECO:0000313|EMBL:CUH44918.1};
OS   Ruegeria atlantica.
OC   Bacteria; Proteobacteria; Alphaproteobacteria; Rhodobacterales;
OC   Rhodobacteraceae; Ruegeria.
OX   NCBI_TaxID=81569 {ECO:0000313|EMBL:CUH44918.1, ECO:0000313|Proteomes:UP000050786};
RN   [1] {ECO:0000313|EMBL:CUH44918.1, ECO:0000313|Proteomes:UP000050786}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=CECT 4293 {ECO:0000313|EMBL:CUH44918.1,
RC   ECO:0000313|Proteomes:UP000050786};
RG   Swine Surveillance;
RL   Submitted (SEP-2015) to the EMBL/GenBank/DDBJ databases.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=5-phospho-D-ribosylamine + ATP + glycine = ADP + H(+) +
CC         N(1)-(5-phospho-D-ribosyl)glycinamide + phosphate;
CC         Xref=Rhea:RHEA:17453, ChEBI:CHEBI:15378, ChEBI:CHEBI:30616,
CC         ChEBI:CHEBI:43474, ChEBI:CHEBI:57305, ChEBI:CHEBI:58089,
CC         ChEBI:CHEBI:58457, ChEBI:CHEBI:456216; EC=6.3.4.13;
CC         Evidence={ECO:0000256|HAMAP-Rule:MF_00138};
CC   -!- PATHWAY: Purine metabolism; IMP biosynthesis via de novo pathway;
CC       N(1)-(5-phospho-D-ribosyl)glycinamide from 5-phospho-alpha-D-
CC       ribose 1-diphosphate: step 2/2. {ECO:0000256|HAMAP-Rule:MF_00138}.
CC   -!- SIMILARITY: Belongs to the GARS family. {ECO:0000256|HAMAP-
CC       Rule:MF_00138}.
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DR   EMBL; CYPS01000057; CUH44918.1; -; Genomic_DNA.
DR   RefSeq; WP_058274849.1; NZ_CYPS01000057.1.
DR   EnsemblBacteria; CUH44918; CUH44918; RUM4293_03827.
DR   UniPathway; UPA00074; UER00125.
DR   Proteomes; UP000050786; Unassembled WGS sequence.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0046872; F:metal ion binding; IEA:InterPro.
DR   GO; GO:0004637; F:phosphoribosylamine-glycine ligase activity; IEA:UniProtKB-UniRule.
DR   GO; GO:0006189; P:'de novo' IMP biosynthetic process; IEA:UniProtKB-UniRule.
DR   GO; GO:0009113; P:purine nucleobase biosynthetic process; IEA:InterPro.
DR   Gene3D; 3.30.1490.20; -; 1.
DR   Gene3D; 3.90.600.10; -; 1.
DR   HAMAP; MF_00138; GARS; 1.
DR   InterPro; IPR011761; ATP-grasp.
DR   InterPro; IPR013815; ATP_grasp_subdomain_1.
DR   InterPro; IPR016185; PreATP-grasp_dom_sf.
DR   InterPro; IPR020561; PRibGlycinamid_synth_ATP-grasp.
DR   InterPro; IPR000115; PRibGlycinamide_synth.
DR   InterPro; IPR020560; PRibGlycinamide_synth_C-dom.
DR   InterPro; IPR037123; PRibGlycinamide_synth_C_sf.
DR   InterPro; IPR020559; PRibGlycinamide_synth_CS.
DR   InterPro; IPR020562; PRibGlycinamide_synth_N.
DR   InterPro; IPR011054; Rudment_hybrid_motif.
DR   Pfam; PF01071; GARS_A; 1.
DR   Pfam; PF02843; GARS_C; 1.
DR   Pfam; PF02844; GARS_N; 1.
DR   SMART; SM01210; GARS_C; 1.
DR   SUPFAM; SSF51246; SSF51246; 1.
DR   SUPFAM; SSF52440; SSF52440; 1.
DR   TIGRFAMs; TIGR00877; purD; 1.
DR   PROSITE; PS50975; ATP_GRASP; 1.
DR   PROSITE; PS00184; GARS; 1.
PE   3: Inferred from homology;
KW   ATP-binding {ECO:0000256|PROSITE-ProRule:PRU00409};
KW   Complete proteome {ECO:0000313|Proteomes:UP000050786};
KW   Ligase {ECO:0000256|HAMAP-Rule:MF_00138, ECO:0000313|EMBL:CUH44918.1};
KW   Nucleotide-binding {ECO:0000256|PROSITE-ProRule:PRU00409};
KW   Purine biosynthesis {ECO:0000256|HAMAP-Rule:MF_00138}.
FT   DOMAIN      107    312       ATP-grasp. {ECO:0000259|PROSITE:PS50975}.
SQ   SEQUENCE   420 AA;  44222 MW;  3AA39CFA8265517C CRC64;
     MNILILGSGG REHSLAWAVM QNPKCDRLIV APGNAGIAQI AECAALDVEN GGAVVSFAEE
     NAIDFVIVGP EAPLAAGVAD RLREAGVLVF GPSADAAQLE ASKSFTKEIC DASNAPTAAY
     ARFTEAEPAK AYVREQGTPI VVKADGLAAG KGVIVAMDEQ TALEGIDDMF GGAFGGAGAE
     VVIEEFMEGE EASLFVLCDG EDILSIGTAQ DHKRVGEGDT GPNTGGMGAY SPAPVLSAEI
     EARAMEEIVR PTMAEMKRRG MPFQGVLYAG LMIKDAQPRL VEYNVRFGDP ECQVLMMRLG
     AQVLDLLHAA AEGRLSETQV NWADDHAITV VMAAQGYPGS YVKGSAIKGL DALPEDSSNM
     IFHAGTKAVD GQVQAAGGRV LNVTSRGATL KEARDRAYAM VEGVDWPEGF YRRDIGWRAL
//
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