ID A0A0P1G2F2_9RHOB Unreviewed; 306 AA.
AC A0A0P1G2F2;
DT 20-JAN-2016, integrated into UniProtKB/TrEMBL.
DT 20-JAN-2016, sequence version 1.
DT 27-MAR-2024, entry version 25.
DE SubName: Full=2-hydroxy-3-oxopropionate reductase {ECO:0000313|EMBL:CUH75989.1};
DE EC=1.1.1.60 {ECO:0000313|EMBL:CUH75989.1};
GN Name=garR_1 {ECO:0000313|EMBL:CUH75989.1};
GN ORFNames=TRN7648_00726 {ECO:0000313|EMBL:CUH75989.1};
OS Tropicibacter naphthalenivorans.
OC Bacteria; Pseudomonadota; Alphaproteobacteria; Rhodobacterales;
OC Roseobacteraceae; Tropicibacter.
OX NCBI_TaxID=441103 {ECO:0000313|EMBL:CUH75989.1, ECO:0000313|Proteomes:UP000054935};
RN [1] {ECO:0000313|EMBL:CUH75989.1, ECO:0000313|Proteomes:UP000054935}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=CECT 7648 {ECO:0000313|EMBL:CUH75989.1,
RC ECO:0000313|Proteomes:UP000054935};
RG Swine Surveillance;
RL Submitted (SEP-2015) to the EMBL/GenBank/DDBJ databases.
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DR EMBL; CYSE01000001; CUH75989.1; -; Genomic_DNA.
DR RefSeq; WP_058246239.1; NZ_FWXX01000001.1.
DR AlphaFoldDB; A0A0P1G2F2; -.
DR STRING; 441103.TRN7648_00726; -.
DR OrthoDB; 9812907at2; -.
DR Proteomes; UP000054935; Unassembled WGS sequence.
DR GO; GO:0008679; F:2-hydroxy-3-oxopropionate reductase activity; IEA:UniProtKB-EC.
DR GO; GO:0051287; F:NAD binding; IEA:InterPro.
DR GO; GO:0050661; F:NADP binding; IEA:InterPro.
DR GO; GO:0016054; P:organic acid catabolic process; IEA:UniProt.
DR Gene3D; 3.40.50.720; NAD(P)-binding Rossmann-like Domain; 1.
DR InterPro; IPR008927; 6-PGluconate_DH-like_C_sf.
DR InterPro; IPR013328; 6PGD_dom2.
DR InterPro; IPR006115; 6PGDH_NADP-bd.
DR InterPro; IPR029154; HIBADH-like_NADP-bd.
DR InterPro; IPR015815; HIBADH-related.
DR InterPro; IPR036291; NAD(P)-bd_dom_sf.
DR PANTHER; PTHR43060; 3-HYDROXYISOBUTYRATE DEHYDROGENASE-LIKE 1, MITOCHONDRIAL-RELATED; 1.
DR PANTHER; PTHR43060:SF15; 3-HYDROXYISOBUTYRATE DEHYDROGENASE-LIKE 1, MITOCHONDRIAL-RELATED; 1.
DR Pfam; PF14833; NAD_binding_11; 1.
DR Pfam; PF03446; NAD_binding_2; 1.
DR PIRSF; PIRSF000103; HIBADH; 1.
DR SUPFAM; SSF48179; 6-phosphogluconate dehydrogenase C-terminal domain-like; 1.
DR SUPFAM; SSF51735; NAD(P)-binding Rossmann-fold domains; 1.
PE 4: Predicted;
KW NAD {ECO:0000256|ARBA:ARBA00023027};
KW Oxidoreductase {ECO:0000313|EMBL:CUH75989.1};
KW Reference proteome {ECO:0000313|Proteomes:UP000054935}.
FT DOMAIN 7..166
FT /note="6-phosphogluconate dehydrogenase NADP-binding"
FT /evidence="ECO:0000259|Pfam:PF03446"
FT DOMAIN 169..280
FT /note="3-hydroxyisobutyrate dehydrogenase-like NAD-binding"
FT /evidence="ECO:0000259|Pfam:PF14833"
FT ACT_SITE 175
FT /evidence="ECO:0000256|PIRSR:PIRSR000103-1"
SQ SEQUENCE 306 AA; 32235 MW; 2F0FC4A3CD50AE77 CRC64;
MSDTPVIGFI GVGLMGHGMA KNILEGGYPL VIKGNRNRAP VEDLVARGAT EVQTPREMAE
QCDIIHLCLS NSPLIEAVMG GEDGILAGAR EGLIVVDTST ADPTSTARLA QALGEKCAHM
VDAPLGRTPK EAEEGTLDAM VGAEDAVFAK VLPVIACWAG NINHVGGVGA GHKMKLLMNM
IAMSYAALYA EATVLGAKVG ISPQTVQKVI GSSRLGNGFF DTFMEYTVGR NKDAHKFTIT
NASKDVRYAN AMAAEAGALS LIGAATRQYF THVEAIGHGE DYVPWLSDHV GRLNGVDLED
EVRKGS
//
