ID A0A0P1G3W3_9RHOB Unreviewed; 851 AA.
AC A0A0P1G3W3;
DT 20-JAN-2016, integrated into UniProtKB/TrEMBL.
DT 20-JAN-2016, sequence version 1.
DT 27-MAR-2024, entry version 35.
DE RecName: Full=DNA 3'-5' helicase {ECO:0000256|ARBA:ARBA00034808};
DE EC=5.6.2.4 {ECO:0000256|ARBA:ARBA00034808};
DE AltName: Full=DNA 3'-5' helicase II {ECO:0000256|ARBA:ARBA00034923};
GN Name=uvrD {ECO:0000313|EMBL:CUH76485.1};
GN ORFNames=TRN7648_00960 {ECO:0000313|EMBL:CUH76485.1};
OS Tropicibacter naphthalenivorans.
OC Bacteria; Pseudomonadota; Alphaproteobacteria; Rhodobacterales;
OC Roseobacteraceae; Tropicibacter.
OX NCBI_TaxID=441103 {ECO:0000313|EMBL:CUH76485.1, ECO:0000313|Proteomes:UP000054935};
RN [1] {ECO:0000313|EMBL:CUH76485.1, ECO:0000313|Proteomes:UP000054935}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=CECT 7648 {ECO:0000313|EMBL:CUH76485.1,
RC ECO:0000313|Proteomes:UP000054935};
RG Swine Surveillance;
RL Submitted (SEP-2015) to the EMBL/GenBank/DDBJ databases.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=ATP + H2O = ADP + H(+) + phosphate; Xref=Rhea:RHEA:13065,
CC ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:30616,
CC ChEBI:CHEBI:43474, ChEBI:CHEBI:456216; EC=5.6.2.4;
CC Evidence={ECO:0000256|ARBA:ARBA00034618};
CC -!- CATALYTIC ACTIVITY:
CC Reaction=Couples ATP hydrolysis with the unwinding of duplex DNA by
CC translocating in the 3'-5' direction.; EC=5.6.2.4;
CC Evidence={ECO:0000256|ARBA:ARBA00034617};
CC -!- SIMILARITY: Belongs to the helicase family. UvrD subfamily.
CC {ECO:0000256|ARBA:ARBA00009922}.
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DR EMBL; CYSE01000002; CUH76485.1; -; Genomic_DNA.
DR RefSeq; WP_058246509.1; NZ_FWXX01000002.1.
DR AlphaFoldDB; A0A0P1G3W3; -.
DR STRING; 441103.TRN7648_00960; -.
DR OrthoDB; 9806690at2; -.
DR Proteomes; UP000054935; Unassembled WGS sequence.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR GO; GO:0016887; F:ATP hydrolysis activity; IEA:RHEA.
DR GO; GO:0003677; F:DNA binding; IEA:InterPro.
DR GO; GO:0003678; F:DNA helicase activity; IEA:InterPro.
DR CDD; cd17932; DEXQc_UvrD; 1.
DR CDD; cd18807; SF1_C_UvrD; 1.
DR Gene3D; 1.10.10.160; -; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 3.
DR InterPro; IPR013986; DExx_box_DNA_helicase_dom_sf.
DR InterPro; IPR014017; DNA_helicase_UvrD-like_C.
DR InterPro; IPR000212; DNA_helicase_UvrD/REP.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR014016; UvrD-like_ATP-bd.
DR PANTHER; PTHR11070:SF2; ATP-DEPENDENT DNA HELICASE SRS2; 1.
DR PANTHER; PTHR11070; UVRD / RECB / PCRA DNA HELICASE FAMILY MEMBER; 1.
DR Pfam; PF00580; UvrD-helicase; 1.
DR Pfam; PF13361; UvrD_C; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR PROSITE; PS51198; UVRD_HELICASE_ATP_BIND; 1.
DR PROSITE; PS51217; UVRD_HELICASE_CTER; 1.
PE 3: Inferred from homology;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840, ECO:0000256|PROSITE-
KW ProRule:PRU00560};
KW Helicase {ECO:0000256|ARBA:ARBA00022806, ECO:0000256|PROSITE-
KW ProRule:PRU00560};
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801, ECO:0000256|PROSITE-
KW ProRule:PRU00560};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741, ECO:0000256|PROSITE-
KW ProRule:PRU00560}; Reference proteome {ECO:0000313|Proteomes:UP000054935}.
FT DOMAIN 29..309
FT /note="UvrD-like helicase ATP-binding"
FT /evidence="ECO:0000259|PROSITE:PS51198"
FT DOMAIN 310..652
FT /note="UvrD-like helicase C-terminal"
FT /evidence="ECO:0000259|PROSITE:PS51217"
FT BINDING 50..57
FT /ligand="ATP"
FT /ligand_id="ChEBI:CHEBI:30616"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00560"
SQ SEQUENCE 851 AA; 95624 MW; FE0D6D72E4BA5574 CRC64;
MSSYDDFDAF EASSLSARAM AARPAPYLDE LNPAQREAVE ALDGPVLMLA GAGTGKTKAL
TARVVHLLNT GRARPNEILS VTFTNKAARE MKNRISRMLG QTVEGMPWLG TFHSICVKLL
RRHAELVGLK SNFTILDTDD QIRLLKQLIQ AAGIDDKRWP ARQLANIIDG WKNRALTPDK
IPSADAGAYN YAGPKLYAQY QERLRELNAV DFGDLLLHMV VIFQTHEDVL EQYQRWFRYI
LVDEYQDTNV AQYMWLRLLA QKHRNICCVG DDDQSIYGWR GAEVGNILRF EKDFEGAHVV
RLEQNYRSTP HILAAASSVI RGNTNRLGKE LWTEAEDGEK VRLIGHWDGE EEARWIGEEI
EAQQGGTRGG RPYSLDDMAI LVRASHQMRA FEDRFLTIGL PYRVIGGPRF YERMEIRDAM
AYFRCVVSPD DDLAFERIVN TPKRGLGDKA QQTIQRIARE NGVSLVNGAA MAVEQGAIKG
KGAKALGELT TRASSWRFLQ VNVGNQVVID EFKAESADHS AKILRLMEQF ASEDAVIDDE
NLGTRSNEDI QYEIDQLKSR IQVLEVYIEI LEGNHVRFAE LILDESGYTE MWQNDKTPEA
PGRLENLKEL VKALESFENL QGFLEHVSLV MDNESDDGGA KVSIMTLHAA KGLEFPVVFL
PGWEDGLFPS QRSMDESGVK GLEEERRLAY VGITRAEELC TISFAGNRRV FGQWQSQMPS
RFVDELPEDH VDILTPPGLY GGGYGAAAPT GMKSNLETRV AEANVYNSPG WRRLQERQSD
RPVSQPRESR NTVIDLTAVS AYTTGERVFH NKFGYGEIIG IEGDKLEIDF EKAGTKKVVS
RFICAADDVP F
//
