ID A0A0P1GK90_9RHOB Unreviewed; 613 AA.
AC A0A0P1GK90;
DT 20-JAN-2016, integrated into UniProtKB/TrEMBL.
DT 20-JAN-2016, sequence version 1.
DT 27-MAR-2024, entry version 28.
DE SubName: Full=3D-(3,5/4)-trihydroxycyclohexane-1,2-dione hydrolase {ECO:0000313|EMBL:CUH82590.1};
DE EC=3.7.1.- {ECO:0000313|EMBL:CUH82590.1};
GN Name=iolD {ECO:0000313|EMBL:CUH82590.1};
GN ORFNames=TRN7648_04132 {ECO:0000313|EMBL:CUH82590.1};
OS Tropicibacter naphthalenivorans.
OC Bacteria; Pseudomonadota; Alphaproteobacteria; Rhodobacterales;
OC Roseobacteraceae; Tropicibacter.
OX NCBI_TaxID=441103 {ECO:0000313|EMBL:CUH82590.1, ECO:0000313|Proteomes:UP000054935};
RN [1] {ECO:0000313|EMBL:CUH82590.1, ECO:0000313|Proteomes:UP000054935}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=CECT 7648 {ECO:0000313|EMBL:CUH82590.1,
RC ECO:0000313|Proteomes:UP000054935};
RG Swine Surveillance;
RL Submitted (SEP-2015) to the EMBL/GenBank/DDBJ databases.
CC -!- SIMILARITY: Belongs to the TPP enzyme family.
CC {ECO:0000256|ARBA:ARBA00007812, ECO:0000256|RuleBase:RU362132}.
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DR EMBL; CYSE01000016; CUH82590.1; -; Genomic_DNA.
DR RefSeq; WP_058249478.1; NZ_FWXX01000019.1.
DR AlphaFoldDB; A0A0P1GK90; -.
DR STRING; 441103.TRN7648_04132; -.
DR OrthoDB; 3194735at2; -.
DR Proteomes; UP000054935; Unassembled WGS sequence.
DR GO; GO:0016823; F:hydrolase activity, acting on acid carbon-carbon bonds, in ketonic substances; IEA:InterPro.
DR GO; GO:0000287; F:magnesium ion binding; IEA:InterPro.
DR GO; GO:0030976; F:thiamine pyrophosphate binding; IEA:InterPro.
DR GO; GO:0016740; F:transferase activity; IEA:UniProtKB-KW.
DR GO; GO:0019310; P:inositol catabolic process; IEA:InterPro.
DR CDD; cd07035; TPP_PYR_POX_like; 1.
DR Gene3D; 3.40.50.970; -; 2.
DR Gene3D; 3.40.50.1220; TPP-binding domain; 1.
DR InterPro; IPR029035; DHS-like_NAD/FAD-binding_dom.
DR InterPro; IPR030817; Myo_inos_IolD.
DR InterPro; IPR029061; THDP-binding.
DR InterPro; IPR012000; Thiamin_PyroP_enz_cen_dom.
DR InterPro; IPR012001; Thiamin_PyroP_enz_TPP-bd_dom.
DR InterPro; IPR000399; TPP-bd_CS.
DR InterPro; IPR045229; TPP_enz.
DR InterPro; IPR011766; TPP_enzyme_TPP-bd.
DR NCBIfam; TIGR04377; myo_inos_iolD; 1.
DR PANTHER; PTHR18968:SF9; 3D-(3,5_4)-TRIHYDROXYCYCLOHEXANE-1,2-DIONE HYDROLASE; 1.
DR PANTHER; PTHR18968; THIAMINE PYROPHOSPHATE ENZYMES; 1.
DR Pfam; PF02775; TPP_enzyme_C; 1.
DR Pfam; PF00205; TPP_enzyme_M; 1.
DR Pfam; PF02776; TPP_enzyme_N; 1.
DR SUPFAM; SSF52467; DHS-like NAD/FAD-binding domain; 1.
DR SUPFAM; SSF52518; Thiamin diphosphate-binding fold (THDP-binding); 2.
DR PROSITE; PS00187; TPP_ENZYMES; 1.
PE 3: Inferred from homology;
KW Hydrolase {ECO:0000313|EMBL:CUH82590.1};
KW Reference proteome {ECO:0000313|Proteomes:UP000054935};
KW Thiamine pyrophosphate {ECO:0000256|RuleBase:RU362132};
KW Transferase {ECO:0000256|ARBA:ARBA00022679}.
FT DOMAIN 9..129
FT /note="Thiamine pyrophosphate enzyme N-terminal TPP-
FT binding"
FT /evidence="ECO:0000259|Pfam:PF02776"
FT DOMAIN 217..349
FT /note="Thiamine pyrophosphate enzyme central"
FT /evidence="ECO:0000259|Pfam:PF00205"
FT DOMAIN 413..565
FT /note="Thiamine pyrophosphate enzyme TPP-binding"
FT /evidence="ECO:0000259|Pfam:PF02775"
SQ SEQUENCE 613 AA; 65300 MW; 9B7CEA772101F361 CRC64;
MGTIRLTAAQ AMVKWLSVQM TEDGPRFIDG IWAIFGHGNV AGLGEALHDA QEVFPTWRGQ
NEQTMAHTAI AYAKAHGRRR AMAVTTSIGP GATNLVTAAA LAHVNRLPLL LIPGDVFANR
RPDPVLQQVE DFDDGTVSAN DCLRPVSRYF DRITRPEHLL TCLPRAMAVM TDPANCGPVT
LAFCQDVQAE AFDYPEEFFE PRVWRVRRPE PDAQELDEVI GLIRSAKTPV IVCGGGVIYS
GAEAALGAFA AKHQIPVVET QAGKSALAQA HEMNFGASGV DGSAAANAVS ETADLVIGVG
TRFQDFTTGS WSLFKNPARR LVSINVAAYD AVKHGAVPLV ADAKVALEKI SAALGDHAAS
APDAKLRSEW LDAVTAHCAP RDGGIGYRPL DAEVIGAVQR ATGEDAVAMC AAGTMPGALK
LLWQPSQGGF HMEYGFSCMG YEIAGAMGIK LATPEREVIC FVGDGSYMMA NSELATAVMR
RVPFTVVLTD NRGYGCINRL QTLGCGGAPF NNLYENCAVE DQPQIDYVAH AASMGAHAVK
AADIASLEAE IANARGRNIP TVIVIETNPA ESPGFGDAGH WWDVAVPAVS DREGVNKAYA
SYLENMARQR LVN
//
