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Database: UniProt
Entry: A0A0P1GPK7_9RHOB
LinkDB: A0A0P1GPK7_9RHOB
Original site: A0A0P1GPK7_9RHOB 
ID   A0A0P1GPK7_9RHOB        Unreviewed;       488 AA.
AC   A0A0P1GPK7;
DT   20-JAN-2016, integrated into UniProtKB/TrEMBL.
DT   20-JAN-2016, sequence version 1.
DT   16-JAN-2019, entry version 23.
DE   RecName: Full=Chromosomal replication initiator protein DnaA {ECO:0000256|HAMAP-Rule:MF_00377, ECO:0000256|RuleBase:RU000577, ECO:0000256|SAAS:SAAS01081161};
GN   Name=dnaA {ECO:0000256|HAMAP-Rule:MF_00377,
GN   ECO:0000313|EMBL:CUH84341.1};
GN   ORFNames=TM5383_01549 {ECO:0000313|EMBL:CUH84341.1};
OS   Thalassobius mediterraneus.
OC   Bacteria; Proteobacteria; Alphaproteobacteria; Rhodobacterales;
OC   Rhodobacteraceae; Thalassobius.
OX   NCBI_TaxID=340021 {ECO:0000313|EMBL:CUH84341.1, ECO:0000313|Proteomes:UP000051681};
RN   [1] {ECO:0000313|EMBL:CUH84341.1, ECO:0000313|Proteomes:UP000051681}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=CECT 8383 {ECO:0000313|EMBL:CUH84341.1,
RC   ECO:0000313|Proteomes:UP000051681};
RG   Swine Surveillance;
RL   Submitted (SEP-2015) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Plays an important role in the initiation and regulation
CC       of chromosomal replication. Binds to the origin of replication; it
CC       binds specifically double-stranded DNA at a 9 bp consensus (dnaA
CC       box): 5'-TTATC[CA]A[CA]A-3'. DnaA binds to ATP and to acidic
CC       phospholipids. {ECO:0000256|HAMAP-Rule:MF_00377,
CC       ECO:0000256|RuleBase:RU000577, ECO:0000256|SAAS:SAAS00756121}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000256|HAMAP-Rule:MF_00377,
CC       ECO:0000256|SAAS:SAAS01082709}.
CC   -!- SIMILARITY: Belongs to the DnaA family. {ECO:0000256|HAMAP-
CC       Rule:MF_00377, ECO:0000256|RuleBase:RU004227,
CC       ECO:0000256|SAAS:SAAS00555179}.
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DR   EMBL; CYSF01000007; CUH84341.1; -; Genomic_DNA.
DR   RefSeq; WP_058318465.1; NZ_FTNX01000005.1.
DR   EnsemblBacteria; CUH84341; CUH84341; TM5383_01549.
DR   OrthoDB; 219876at2; -.
DR   Proteomes; UP000051681; Unassembled WGS sequence.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0003688; F:DNA replication origin binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0006270; P:DNA replication initiation; IEA:UniProtKB-UniRule.
DR   GO; GO:0006275; P:regulation of DNA replication; IEA:UniProtKB-UniRule.
DR   CDD; cd06571; Bac_DnaA_C; 1.
DR   Gene3D; 1.10.1750.10; -; 1.
DR   Gene3D; 3.30.300.180; -; 1.
DR   HAMAP; MF_00377; DnaA_bact; 1.
DR   InterPro; IPR003593; AAA+_ATPase.
DR   InterPro; IPR001957; Chromosome_initiator_DnaA.
DR   InterPro; IPR020591; Chromosome_initiator_DnaA-like.
DR   InterPro; IPR018312; Chromosome_initiator_DnaA_CS.
DR   InterPro; IPR013317; DnaA.
DR   InterPro; IPR013159; DnaA_C.
DR   InterPro; IPR024633; DnaA_N_dom.
DR   InterPro; IPR038454; DnaA_N_sf.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   InterPro; IPR010921; Trp_repressor/repl_initiator.
DR   PANTHER; PTHR30050:SF2; PTHR30050:SF2; 1.
DR   Pfam; PF00308; Bac_DnaA; 1.
DR   Pfam; PF08299; Bac_DnaA_C; 1.
DR   Pfam; PF11638; DnaA_N; 1.
DR   PRINTS; PR00051; DNAA.
DR   SMART; SM00382; AAA; 1.
DR   SMART; SM00760; Bac_DnaA_C; 1.
DR   SUPFAM; SSF48295; SSF48295; 1.
DR   SUPFAM; SSF52540; SSF52540; 1.
DR   TIGRFAMs; TIGR00362; DnaA; 1.
DR   PROSITE; PS01008; DNAA; 1.
PE   3: Inferred from homology;
KW   ATP-binding {ECO:0000256|HAMAP-Rule:MF_00377,
KW   ECO:0000256|RuleBase:RU000577, ECO:0000256|SAAS:SAAS00756129};
KW   Complete proteome {ECO:0000313|Proteomes:UP000051681};
KW   Cytoplasm {ECO:0000256|HAMAP-Rule:MF_00377,
KW   ECO:0000256|SAAS:SAAS01082702};
KW   DNA replication {ECO:0000256|HAMAP-Rule:MF_00377,
KW   ECO:0000256|RuleBase:RU004227, ECO:0000256|SAAS:SAAS00756116};
KW   DNA-binding {ECO:0000256|HAMAP-Rule:MF_00377,
KW   ECO:0000256|RuleBase:RU000577, ECO:0000256|SAAS:SAAS01082706};
KW   Nucleotide-binding {ECO:0000256|HAMAP-Rule:MF_00377,
KW   ECO:0000256|RuleBase:RU000577, ECO:0000256|SAAS:SAAS00756117};
KW   Reference proteome {ECO:0000313|Proteomes:UP000051681}.
FT   DOMAIN      180    310       AAA. {ECO:0000259|SMART:SM00382}.
FT   DOMAIN      396    465       Bac_DnaA_C. {ECO:0000259|SMART:SM00760}.
FT   NP_BIND     188    195       ATP. {ECO:0000256|HAMAP-Rule:MF_00377}.
SQ   SEQUENCE   488 AA;  54474 MW;  93B72AD23A97C6BC CRC64;
     MTQDQWGQLK QNLLNTVGKN NFATWIEPLE FVEIADGVAS FQAPTTFLGN YVSQNFGDLI
     VHKLNEGGAN VRRIHFRVGT STPRPQAPAA RPAAAPAAYE TVTASAAPAA QPRLADAPET
     IRPATVESIT DSPVDGAIAQ DLLPGAPLDA RFTFDTFVVG KPNELAHAAA RRVAEGGPVT
     FNPLFLYGGV GLGKTHLMHA IAWELQTKRP DLNVVYLSAE QFMYRFVQAL RDRKMMDFKQ
     LFRSVDVLMV DDVQFIAGKD STQEEFFHTF NALVDQNKQI IISADRAPGE IKDLEDRIKS
     RLQCGLVVDL HPTDYELRLG ILQSKVEQHS QQYPGLELAP GVLEFLAHRI STNVRVLEGA
     LTRLFAFASL VGRPITMELT QDCLADVLRA SERKITVEEI QRKVSEHYNI RLSDMIGPKR
     VRTYARPRQV AMYLCKQLTS RSLPEIGRRF GGRDHTTVMH GVKRIEELRQ QDGQIAEDLE
     LLRRALEA
//
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