ID A0A0P1H0L8_9RHOB Unreviewed; 438 AA.
AC A0A0P1H0L8;
DT 20-JAN-2016, integrated into UniProtKB/TrEMBL.
DT 20-JAN-2016, sequence version 1.
DT 27-MAR-2024, entry version 25.
DE SubName: Full=3-hydroxyisobutyrate dehydrogenase {ECO:0000313|EMBL:CUH81267.1};
DE EC=1.1.1.31 {ECO:0000313|EMBL:CUH81267.1};
GN Name=mmsB_2 {ECO:0000313|EMBL:CUH81267.1};
GN ORFNames=TRN7648_03394 {ECO:0000313|EMBL:CUH81267.1};
OS Tropicibacter naphthalenivorans.
OC Bacteria; Pseudomonadota; Alphaproteobacteria; Rhodobacterales;
OC Roseobacteraceae; Tropicibacter.
OX NCBI_TaxID=441103 {ECO:0000313|EMBL:CUH81267.1, ECO:0000313|Proteomes:UP000054935};
RN [1] {ECO:0000313|EMBL:CUH81267.1, ECO:0000313|Proteomes:UP000054935}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=CECT 7648 {ECO:0000313|EMBL:CUH81267.1,
RC ECO:0000313|Proteomes:UP000054935};
RG Swine Surveillance;
RL Submitted (SEP-2015) to the EMBL/GenBank/DDBJ databases.
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DR EMBL; CYSE01000007; CUH81267.1; -; Genomic_DNA.
DR RefSeq; WP_058248827.1; NZ_FWXX01000008.1.
DR AlphaFoldDB; A0A0P1H0L8; -.
DR STRING; 441103.TRN7648_03394; -.
DR Proteomes; UP000054935; Unassembled WGS sequence.
DR GO; GO:0008442; F:3-hydroxyisobutyrate dehydrogenase activity; IEA:UniProtKB-EC.
DR GO; GO:0051287; F:NAD binding; IEA:InterPro.
DR GO; GO:0050661; F:NADP binding; IEA:InterPro.
DR GO; GO:0016054; P:organic acid catabolic process; IEA:UniProt.
DR Gene3D; 3.40.50.720; NAD(P)-binding Rossmann-like Domain; 1.
DR InterPro; IPR008927; 6-PGluconate_DH-like_C_sf.
DR InterPro; IPR013328; 6PGD_dom2.
DR InterPro; IPR006115; 6PGDH_NADP-bd.
DR InterPro; IPR029154; HIBADH-like_NADP-bd.
DR InterPro; IPR036291; NAD(P)-bd_dom_sf.
DR PANTHER; PTHR43060; 3-HYDROXYISOBUTYRATE DEHYDROGENASE-LIKE 1, MITOCHONDRIAL-RELATED; 1.
DR PANTHER; PTHR43060:SF15; 3-HYDROXYISOBUTYRATE DEHYDROGENASE-LIKE 1, MITOCHONDRIAL-RELATED; 1.
DR Pfam; PF14833; NAD_binding_11; 2.
DR Pfam; PF03446; NAD_binding_2; 1.
DR SUPFAM; SSF48179; 6-phosphogluconate dehydrogenase C-terminal domain-like; 2.
DR SUPFAM; SSF51735; NAD(P)-binding Rossmann-fold domains; 1.
PE 4: Predicted;
KW Oxidoreductase {ECO:0000313|EMBL:CUH81267.1};
KW Reference proteome {ECO:0000313|Proteomes:UP000054935}.
FT DOMAIN 2..158
FT /note="6-phosphogluconate dehydrogenase NADP-binding"
FT /evidence="ECO:0000259|Pfam:PF03446"
FT DOMAIN 164..273
FT /note="3-hydroxyisobutyrate dehydrogenase-like NAD-binding"
FT /evidence="ECO:0000259|Pfam:PF14833"
FT DOMAIN 314..422
FT /note="3-hydroxyisobutyrate dehydrogenase-like NAD-binding"
FT /evidence="ECO:0000259|Pfam:PF14833"
SQ SEQUENCE 438 AA; 45109 MW; A8AE1268AFD33508 CRC64;
MKIGYVGLGA MGGSLVRWMI PHHEVTVFDL SPDAVAACVA LGARAATSLT DLARACDVVF
LCLPRSANVA EALFGNDGLA EALTPGTIVV DQTSGMATDT RAFAKRLAER GIAMLDAPVA
GGVPSAQAGT ITIMVSGPTE ALDIVQPAFR CMTAKIYHAS EAVGDAQAVK TLNNMMNMVM
RVATLELTAL AVKQGAALPA LTEALIASEG ANFTTRTVLP ALVAGRSVGD FRLALMLKDN
NQALALGTAC NVPMPLSALG RAAVQQNIHI TGAQAGLDEV NSYMQQVCGV RFDAGAGAGL
PEADFARLSQ TIATTLAACN RAAFLETLSV ARALGMDLRA FGDILNNGSA WSRESEAVLA
EVGGAPCPRT LTDAITALRA VEDMSVATGV PLMITGAVRA LFETAQKTLG ADAAQDQLAR
VYETAGGVSL RLKAPEPA
//
