ID A0A0P1HP89_9RHOB Unreviewed; 353 AA.
AC A0A0P1HP89;
DT 20-JAN-2016, integrated into UniProtKB/TrEMBL.
DT 20-JAN-2016, sequence version 1.
DT 27-MAR-2024, entry version 22.
DE SubName: Full=5-methyltetrahydrofolate:corrinoid/iron-sulfur protein co-methyltransferase {ECO:0000313|EMBL:CUH88642.1};
DE EC=2.1.1.258 {ECO:0000313|EMBL:CUH88642.1};
GN Name=acsE {ECO:0000313|EMBL:CUH88642.1};
GN ORFNames=PH5382_02581 {ECO:0000313|EMBL:CUH88642.1};
OS Phaeobacter sp. CECT 5382.
OC Bacteria; Pseudomonadota; Alphaproteobacteria; Rhodobacterales;
OC Roseobacteraceae; Phaeobacter.
OX NCBI_TaxID=1712645 {ECO:0000313|EMBL:CUH88642.1, ECO:0000313|Proteomes:UP000050782};
RN [1] {ECO:0000313|EMBL:CUH88642.1, ECO:0000313|Proteomes:UP000050782}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=CECT 5382 {ECO:0000313|EMBL:CUH88642.1,
RC ECO:0000313|Proteomes:UP000050782};
RG Swine Surveillance;
RL Submitted (SEP-2015) to the EMBL/GenBank/DDBJ databases.
CC -!- SIMILARITY: Belongs to the vitamin-B12 dependent methionine synthase
CC family. {ECO:0000256|ARBA:ARBA00010398}.
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DR EMBL; CYSG01000011; CUH88642.1; -; Genomic_DNA.
DR RefSeq; WP_058334773.1; NZ_CYSG01000011.1.
DR AlphaFoldDB; A0A0P1HP89; -.
DR STRING; 1712645.PH5382_02581; -.
DR OrthoDB; 9803687at2; -.
DR Proteomes; UP000050782; Unassembled WGS sequence.
DR GO; GO:0102036; F:methyltetrahydrofolate:corrinoid/iron-sulfur protein methyltransferase activity; IEA:UniProtKB-EC.
DR GO; GO:0032259; P:methylation; IEA:UniProtKB-KW.
DR GO; GO:0042558; P:pteridine-containing compound metabolic process; IEA:InterPro.
DR Gene3D; 3.20.20.20; Dihydropteroate synthase-like; 1.
DR InterPro; IPR011005; Dihydropteroate_synth-like_sf.
DR InterPro; IPR000489; Pterin-binding_dom.
DR PANTHER; PTHR45833; METHIONINE SYNTHASE; 1.
DR PANTHER; PTHR45833:SF1; METHIONINE SYNTHASE; 1.
DR Pfam; PF00809; Pterin_bind; 1.
DR SUPFAM; SSF51717; Dihydropteroate synthetase-like; 1.
DR PROSITE; PS50972; PTERIN_BINDING; 1.
PE 3: Inferred from homology;
KW Cobalt {ECO:0000256|ARBA:ARBA00023285};
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW Methyltransferase {ECO:0000256|ARBA:ARBA00022603,
KW ECO:0000313|EMBL:CUH88642.1};
KW Reference proteome {ECO:0000313|Proteomes:UP000050782};
KW Transferase {ECO:0000256|ARBA:ARBA00022679, ECO:0000313|EMBL:CUH88642.1}.
FT DOMAIN 21..274
FT /note="Pterin-binding"
FT /evidence="ECO:0000259|PROSITE:PS50972"
FT REGION 323..353
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 328..344
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 353 AA; 37525 MW; 6729F376098B0496 CRC64;
MTRTVVESKT KTAVMGFDEP FCVIGERINP TGRKKLAAEL EAGDFSTVEK DAVAQVLAGA
TVLDINAGVV YNSNPNPNET EPPLMKKIVE LVQGLVDVPL CIDSSVPGAL EAGLEVCEGR
PLLNSVTGEE ERLEQILPLV KKYNVPVVAI SNDDTGISED PDVRFEVAKK IVQRAADFGI
PAHDIVVDPL VMPVGAMGTA GLQVFALVRR LREELGVNTT CGASNISFGL PNRHGINNAF
LPMAMGAGMT SAIMNPVGLP VTQKALAAKK EEVAAAGIIL PEGMDDETFV TMFGLGSMKP
RAGKEMEAIR AANFLTNNDP HGGEWIKFNK APAKEGEEGR GRGGRSGGRR RRA
//
