ID A0A0P1L619_9BACT Unreviewed; 664 AA.
AC A0A0P1L619; A0A0P1LGL8; A0A0P1LJJ8; A0A0P1M9B9; A0A0P1ME87; A0A0P1MMR2;
AC A0A0P1MXC7; A0A0P1P6Y9; A0A0S4NAE2;
DT 20-JAN-2016, integrated into UniProtKB/TrEMBL.
DT 20-JAN-2016, sequence version 1.
DT 27-MAR-2024, entry version 44.
DE SubName: Full=Kef-type potassium/proton antiporter, CPA2 family {ECO:0000313|EMBL:CUU08016.1};
GN ORFNames=JGI4_01959 {ECO:0000313|EMBL:CUU08016.1};
OS Candidatus Kryptonium thompsoni.
OC Bacteria; Candidatus Kryptonia; Kryptonium.
OX NCBI_TaxID=1633631 {ECO:0000313|EMBL:CUU08016.1, ECO:0000313|Proteomes:UP000182011};
RN [1] {ECO:0000313|EMBL:CUU08016.1, ECO:0000313|Proteomes:UP000182011}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=JGI-4 {ECO:0000313|EMBL:CUU08016.1};
RA Zhang Y., Guo Z.;
RL Submitted (NOV-2015) to the EMBL/GenBank/DDBJ databases.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
CC -!- SIMILARITY: Belongs to the monovalent cation:proton antiporter 2 (CPA2)
CC transporter (TC 2.A.37) family. {ECO:0000256|ARBA:ARBA00005551}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; FAOP01000008; CUU08016.1; -; Genomic_DNA.
DR RefSeq; WP_047133261.1; NZ_CZVX01000001.1.
DR AlphaFoldDB; A0A0P1L619; -.
DR STRING; 1633631.GCA_001442925_01954; -.
DR OrthoDB; 9781411at2; -.
DR Proteomes; UP000182011; Unassembled WGS sequence.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0015297; F:antiporter activity; IEA:InterPro.
DR GO; GO:0008324; F:monoatomic cation transmembrane transporter activity; IEA:InterPro.
DR GO; GO:0006813; P:potassium ion transport; IEA:InterPro.
DR GO; GO:1902600; P:proton transmembrane transport; IEA:InterPro.
DR Gene3D; 1.20.1530.20; -; 1.
DR Gene3D; 3.40.50.720; NAD(P)-binding Rossmann-like Domain; 1.
DR Gene3D; 3.30.70.1450; Regulator of K+ conductance, C-terminal domain; 1.
DR InterPro; IPR006153; Cation/H_exchanger.
DR InterPro; IPR038770; Na+/solute_symporter_sf.
DR InterPro; IPR036291; NAD(P)-bd_dom_sf.
DR InterPro; IPR006037; RCK_C.
DR InterPro; IPR036721; RCK_C_sf.
DR InterPro; IPR003148; RCK_N.
DR PANTHER; PTHR42751:SF3; NA(+)_H(+) ANTIPORTER; 1.
DR PANTHER; PTHR42751; SODIUM/HYDROGEN EXCHANGER FAMILY/TRKA DOMAIN PROTEIN; 1.
DR Pfam; PF00999; Na_H_Exchanger; 1.
DR Pfam; PF02080; TrkA_C; 1.
DR Pfam; PF02254; TrkA_N; 1.
DR SUPFAM; SSF51735; NAD(P)-binding Rossmann-fold domains; 1.
DR SUPFAM; SSF116726; TrkA C-terminal domain-like; 1.
DR PROSITE; PS51202; RCK_C; 1.
DR PROSITE; PS51201; RCK_N; 1.
PE 3: Inferred from homology;
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000182011};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}; Transport {ECO:0000256|ARBA:ARBA00022448}.
FT TRANSMEM 6..25
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 32..50
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 56..75
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 87..110
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 116..135
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 147..170
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 176..196
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 217..250
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 270..287
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 294..317
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 323..343
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 355..376
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 406..527
FT /note="RCK N-terminal"
FT /evidence="ECO:0000259|PROSITE:PS51201"
FT DOMAIN 577..661
FT /note="RCK C-terminal"
FT /evidence="ECO:0000259|PROSITE:PS51202"
SQ SEQUENCE 664 AA; 74005 MW; 52B3C9C8BEEF1DD2 CRC64;
MDVVEFLKIF AFIFGISALV VYLLHKVRLP PVIGFLISGV IIGPYGAKLV ERVEVVQVLA
EVGVILLLFV LGLGLSLTKL LEMRRFLLVA GGAQIIMTVF LFTILSLLFF ELNLSIFIGL
IAALSSTAIV LKYLFDSGEI DSSHGRVTTG ITIFQDLVAI FITPFIPLFL SSNFNPINFL
VKLLNSSLIL IFVVWASRKL VPPLLFLIAK SRIRDLFIIS VLFLCFSVAL IVSELGFSLA
FGAFVAGLLI SESEYSHQVT ADIIPFRESL MAIFFVSIGM LLNVNFLMEN FRVVVLISLL
IILIKILGTS LGILISGGGI KTAFISGILL APISEFSFVL ILLGKKFGLV DDRIYQFFIA
SAVITMVLSP ILFTYVHNLA AFVGNYIKVK DESWERLKRE SELREHVIII GFGLNGRSVA
RVLKGIGIPY VVIELNISTV KKMREVGELI FHGDATSPDV LRKAGIEEAK LMIITISDPV
SSKRIVAIAR SLNSNIYIIV RTRYVAEVEE LRKLGANEVI PEEFEISVEI ANRVLSYFKF
PINLTKEYVS KLKEGSYELF RRDDVSFNEL VQNLALPKNL SEHLRRVEFE TYWVKSNSRA
KQTSIGEMAL RSRTGVTVLI VKRGEEIFIN PSADFKFEVG DLVVLMGERN KIEKAIQLLD
NGEA
//
