ID   A0A0P1LPE9_9BACT        Unreviewed;       802 AA.
AC   A0A0P1LPE9; A0A0N7MT52; A0A0P1LGV0; A0A0P1MCV4; A0A0S4N6G1;
DT   20-JAN-2016, integrated into UniProtKB/TrEMBL.
DT   20-JAN-2016, sequence version 1.
DT   27-MAR-2024, entry version 39.
DE   SubName: Full=3-hydroxyacyl-CoA dehydrogenase {ECO:0000313|EMBL:CUU06443.1};
GN   ORFNames=JGI4_01501 {ECO:0000313|EMBL:CUU06443.1};
OS   Candidatus Kryptonium thompsoni.
OC   Bacteria; Candidatus Kryptonia; Kryptonium.
OX   NCBI_TaxID=1633631 {ECO:0000313|EMBL:CUU06443.1, ECO:0000313|Proteomes:UP000182011};
RN   [1] {ECO:0000313|EMBL:CUU06443.1, ECO:0000313|Proteomes:UP000182011}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=JGI-4 {ECO:0000313|EMBL:CUU06443.1};
RA   Zhang Y., Guo Z.;
RL   Submitted (NOV-2015) to the EMBL/GenBank/DDBJ databases.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=a (3S)-3-hydroxyacyl-CoA + NAD(+) = a 3-oxoacyl-CoA + H(+) +
CC         NADH; Xref=Rhea:RHEA:22432, ChEBI:CHEBI:15378, ChEBI:CHEBI:57318,
CC         ChEBI:CHEBI:57540, ChEBI:CHEBI:57945, ChEBI:CHEBI:90726; EC=1.1.1.35;
CC         Evidence={ECO:0000256|ARBA:ARBA00023693};
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DR   EMBL; FAOP01000006; CUU06443.1; -; Genomic_DNA.
DR   RefSeq; WP_075426843.1; NZ_CZVN01000065.1.
DR   AlphaFoldDB; A0A0P1LPE9; -.
DR   STRING; 1633631.GCA_001442925_01496; -.
DR   UniPathway; UPA00659; -.
DR   Proteomes; UP000182011; Unassembled WGS sequence.
DR   GO; GO:0003857; F:3-hydroxyacyl-CoA dehydrogenase activity; IEA:UniProtKB-EC.
DR   GO; GO:0070403; F:NAD+ binding; IEA:InterPro.
DR   GO; GO:0006635; P:fatty acid beta-oxidation; IEA:UniProtKB-UniPathway.
DR   CDD; cd06558; crotonase-like; 1.
DR   Gene3D; 1.10.1040.50; -; 1.
DR   Gene3D; 3.40.50.720; NAD(P)-binding Rossmann-like Domain; 1.
DR   InterPro; IPR006176; 3-OHacyl-CoA_DH_NAD-bd.
DR   InterPro; IPR006108; 3HC_DH_C.
DR   InterPro; IPR008927; 6-PGluconate_DH-like_C_sf.
DR   InterPro; IPR029045; ClpP/crotonase-like_dom_sf.
DR   InterPro; IPR045004; ECH_dom.
DR   InterPro; IPR036291; NAD(P)-bd_dom_sf.
DR   PANTHER; PTHR48075; 3-HYDROXYACYL-COA DEHYDROGENASE FAMILY PROTEIN; 1.
DR   PANTHER; PTHR48075:SF7; 3-HYDROXYACYL-COA DEHYDROGENASE-RELATED; 1.
DR   Pfam; PF00725; 3HCDH; 2.
DR   Pfam; PF02737; 3HCDH_N; 1.
DR   Pfam; PF16113; ECH_2; 1.
DR   SUPFAM; SSF48179; 6-phosphogluconate dehydrogenase C-terminal domain-like; 2.
DR   SUPFAM; SSF52096; ClpP/crotonase; 1.
DR   SUPFAM; SSF51735; NAD(P)-binding Rossmann-fold domains; 1.
PE   4: Predicted;
KW   NAD {ECO:0000256|ARBA:ARBA00023027};
KW   Reference proteome {ECO:0000313|Proteomes:UP000182011}.
FT   DOMAIN          6..204
FT                   /note="3-hydroxyacyl-CoA dehydrogenase NAD binding"
FT                   /evidence="ECO:0000259|Pfam:PF02737"
FT   DOMAIN          207..306
FT                   /note="3-hydroxyacyl-CoA dehydrogenase C-terminal"
FT                   /evidence="ECO:0000259|Pfam:PF00725"
FT   DOMAIN          385..438
FT                   /note="3-hydroxyacyl-CoA dehydrogenase C-terminal"
FT                   /evidence="ECO:0000259|Pfam:PF00725"
FT   DOMAIN          498..629
FT                   /note="Enoyl-CoA hydratase/isomerase"
FT                   /evidence="ECO:0000259|Pfam:PF16113"
SQ   SEQUENCE   802 AA;  90630 MW;  2D8D3E5A366C55CA CRC64;
     MRPIKKVAVL GAGVMGAQIA AHLANAGIPS YLLDIVPKEL TEEEKAKKLT LESPEVRNRI
     VREGLERVKK LKPNAFFIPE LEKLITIGNF EDNLNWLSEV DWIIEAVVER LDIKRELFKK
     VELVRRPGTI VSSNTSGIRI SEIAEGLSDD FRKHFLGTHF FNPPRYMKLL EIIPTPETSK
     EVIETIAEFG EKVLGKGIVY CKDTPNFIAN RIGVFAVMYV LHYMLQNGYT IEEVDELTGP
     VSGKPKSATF RTLDIVGLDT LVHVANNLYN AVPNDEMREY FKVPDVIQKM LENKWLGEKT
     GQGFYKRVKK DGESEILVLD FSTMNYRERQ KVKLGSLEMA KATEGLKDKI QILMNAKDKA
     GEFFWKTTGA VLAYASNRIP EISDTIVDID NAMKWGFNWE LGPFEMWDLM GVEGSLERIE
     KEGFKVADWV KDMVKSGKKK FYEQKDGKIY FYDVVGLKDY VEMKTKPEII NLALLKENKS
     KIIKQNAGAS LIDLGDGVLC LEFHTKMNAI GEDILVMANY SLDELEKNYE ALVIGNQGQH
     FSAGANLMMI LMLAQDGEWD EIDRAVRMFQ KMNMRIKYSP KPVVVAPHGM TLGGGCEIVL
     HAPRVRAYAE SYIGLVEIGA GVIPAGGGTK EMLLRAIQRA PKRDDIDLTP FIREAFETIA
     FAKVSTSALE AKKLGYLREY DTISMNKDYL IYDAKKIALS MVEEGYKPPL PAEIVALGKQ
     LYANFLVGIY LMREANYITE YEAHIGKKLA YIMSGGDFTS PQIVSEQHIL DLEREAFLSL
     CGEKKTQERM QYILKYGKPL RN
//